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Protein

Serine incorporator 1

Gene

Serinc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-977347 Serine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Axotomy-induced glyco/Golgi protein 2
Membrane protein TMS-2
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:Serinc1
Synonyms:Aigp2, Tde1l, Tde2, Tms2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1926228 Serinc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 39CytoplasmicSequence analysisAdd BLAST38
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 88LumenalSequence analysisAdd BLAST28
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 123CytoplasmicSequence analysisAdd BLAST14
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 151LumenalSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 197CytoplasmicSequence analysisAdd BLAST25
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231LumenalSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 259CytoplasmicSequence analysis7
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 309LumenalSequence analysisAdd BLAST29
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 387CytoplasmicSequence analysisAdd BLAST57
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 426LumenalSequence analysisAdd BLAST18
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 453CytoplasmicSequence analysis6

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002189672 – 453Serine incorporator 1Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei352PhosphothreonineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9QZI8
MaxQBiQ9QZI8
PaxDbiQ9QZI8
PRIDEiQ9QZI8

PTM databases

iPTMnetiQ9QZI8
PhosphoSitePlusiQ9QZI8
SwissPalmiQ9QZI8

Expressioni

Tissue specificityi

Highly expressed in the neuronal populations such as Purkinje cells in the cerebellum, brainstem and spinal motor neurons, locus coeruleus and raphe nuclei.

Gene expression databases

BgeeiENSMUSG00000019877 Expressed in 302 organ(s), highest expression level in piriform cortex
CleanExiMM_SERINC1
ExpressionAtlasiQ9QZI8 baseline and differential
GenevisibleiQ9QZI8 MM

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207983, 1 interactor
STRINGi10090.ENSMUSP00000020027

Structurei

3D structure databases

ProteinModelPortaliQ9QZI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ9QZI8
OMAiVCFGMAM
OrthoDBiEOG091G07WS
PhylomeDBiQ9QZI8
TreeFamiTF312881

Family and domain databases

InterProiView protein in InterPro
IPR029552 SERINC1
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF15 PTHR10383:SF15, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QZI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSVLGLCSV ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF ATAVAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAVVLFFVYY THPASCAENK AFISVNMLLC IGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGFNTT
310 320 330 340 350
RPIPKDGQSV QWWHPQGIIG LVLFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGNGR SDGSLDDGDG IHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGLVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,509
Last modified:May 1, 2000 - v1
Checksum:i0FE8718FA3EA62B7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q553E9Q553_MOUSE
Serine incorporator 1
Serinc1
114Annotation score:
E9PY81E9PY81_MOUSE
Serine incorporator 1
Serinc1
220Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181685 mRNA Translation: AAD54421.1
AB078030 Genomic DNA Translation: BAC05512.1
AK002847 mRNA Translation: BAB22403.1
AK005203 mRNA Translation: BAB23881.1
AK088340 mRNA Translation: BAC40293.1
AK133668 mRNA Translation: BAE21775.1
AK133975 mRNA Translation: BAE21964.1
AK135359 mRNA Translation: BAE22504.1
AK141574 mRNA Translation: BAE24743.1
AK148745 mRNA Translation: BAE28654.1
AK159280 mRNA Translation: BAE34958.1
AK159436 mRNA Translation: BAE35082.1
BC017148 mRNA Translation: AAH17148.1
CCDSiCCDS23853.1
RefSeqiNP_062734.1, NM_019760.3
UniGeneiMm.29344

Genome annotation databases

EnsembliENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877
GeneIDi56442
KEGGimmu:56442
UCSCiuc007fcm.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181685 mRNA Translation: AAD54421.1
AB078030 Genomic DNA Translation: BAC05512.1
AK002847 mRNA Translation: BAB22403.1
AK005203 mRNA Translation: BAB23881.1
AK088340 mRNA Translation: BAC40293.1
AK133668 mRNA Translation: BAE21775.1
AK133975 mRNA Translation: BAE21964.1
AK135359 mRNA Translation: BAE22504.1
AK141574 mRNA Translation: BAE24743.1
AK148745 mRNA Translation: BAE28654.1
AK159280 mRNA Translation: BAE34958.1
AK159436 mRNA Translation: BAE35082.1
BC017148 mRNA Translation: AAH17148.1
CCDSiCCDS23853.1
RefSeqiNP_062734.1, NM_019760.3
UniGeneiMm.29344

3D structure databases

ProteinModelPortaliQ9QZI8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207983, 1 interactor
STRINGi10090.ENSMUSP00000020027

PTM databases

iPTMnetiQ9QZI8
PhosphoSitePlusiQ9QZI8
SwissPalmiQ9QZI8

Proteomic databases

EPDiQ9QZI8
MaxQBiQ9QZI8
PaxDbiQ9QZI8
PRIDEiQ9QZI8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020027; ENSMUSP00000020027; ENSMUSG00000019877
GeneIDi56442
KEGGimmu:56442
UCSCiuc007fcm.3 mouse

Organism-specific databases

CTDi57515
MGIiMGI:1926228 Serinc1

Phylogenomic databases

eggNOGiKOG2592 Eukaryota
ENOG410XP7K LUCA
GeneTreeiENSGT00550000074522
HOGENOMiHOG000165463
HOVERGENiHBG025699
InParanoidiQ9QZI8
OMAiVCFGMAM
OrthoDBiEOG091G07WS
PhylomeDBiQ9QZI8
TreeFamiTF312881

Enzyme and pathway databases

ReactomeiR-MMU-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRSiSerinc1 mouse
PROiPR:Q9QZI8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019877 Expressed in 302 organ(s), highest expression level in piriform cortex
CleanExiMM_SERINC1
ExpressionAtlasiQ9QZI8 baseline and differential
GenevisibleiQ9QZI8 MM

Family and domain databases

InterProiView protein in InterPro
IPR029552 SERINC1
IPR005016 TDE1/TMS
PANTHERiPTHR10383 PTHR10383, 1 hit
PTHR10383:SF15 PTHR10383:SF15, 1 hit
PfamiView protein in Pfam
PF03348 Serinc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSERC1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZI8
Secondary accession number(s): Q3UZ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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