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Protein

F-box/LRR-repeat protein 20

Gene

Fbxl20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 20
Alternative name(s):
F-box and leucine-rich repeat protein 20
F-box/LRR-repeat protein 2-like
Gene namesi
Name:Fbxl20
Synonyms:Fbl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621722 Fbxl20

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198721 – 276F-box/LRR-repeat protein 20Add BLAST276

Proteomic databases

PaxDbiQ9QZH7
PRIDEiQ9QZH7

Expressioni

Tissue specificityi

Widely expressed, with highest expression in skeletal muscle, heart and brain.1 Publication

Gene expression databases

GenevisibleiQ9QZH7 RN

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060552

Structurei

3D structure databases

ProteinModelPortaliQ9QZH7
SMRiQ9QZH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 68F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati74 – 100LRR 1Add BLAST27
Repeati101 – 126LRR 2Add BLAST26
Repeati127 – 152LRR 3Add BLAST26
Repeati153 – 178LRR 4Add BLAST26
Repeati179 – 204LRR 5Add BLAST26
Repeati205 – 230LRR 6Add BLAST26
Repeati231 – 256LRR 7Add BLAST26
Repeati257 – 276LRR 8Add BLAST20

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4341 Eukaryota
ENOG410XQ54 LUCA
HOGENOMiHOG000230659
HOVERGENiHBG051586
InParanoidiQ9QZH7
KOiK10268
OrthoDBiEOG091G060Y
PhylomeDBiQ9QZH7

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 3 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 7 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QZH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ
60 70 80 90 100
VSRAWNVLAL DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG
110 120 130 140 150
CLGVGDNALR TFAQNCRNIE VLSLNGCTKT TDATCTSLSK FCSKLRHLDL
160 170 180 190 200
ASCTSITNMS LKALSEGCPL LEQLNISWCD QVTKDGIQAL VRGCGGLKAL
210 220 230 240 250
FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI TICRGCHKLQ
260 270
SLCASGCSNI TDAILNALGQ NCPRLR
Length:276
Mass (Da):30,460
Last modified:May 1, 2000 - v1
Checksum:i982994F91A265E1E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UI14A0A0H2UI14_RAT
F-box/LRR-repeat protein 20
Fbxl20
436Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182443 mRNA Translation: AAF01221.1
PIRiT52349
RefSeqiNP_071608.1, NM_022272.1
UniGeneiRn.11637
Rn.18281

Genome annotation databases

GeneIDi64039
KEGGirno:64039
UCSCiRGD:621722 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182443 mRNA Translation: AAF01221.1
PIRiT52349
RefSeqiNP_071608.1, NM_022272.1
UniGeneiRn.11637
Rn.18281

3D structure databases

ProteinModelPortaliQ9QZH7
SMRiQ9QZH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060552

Proteomic databases

PaxDbiQ9QZH7
PRIDEiQ9QZH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64039
KEGGirno:64039
UCSCiRGD:621722 rat

Organism-specific databases

CTDi84961
RGDi621722 Fbxl20

Phylogenomic databases

eggNOGiKOG4341 Eukaryota
ENOG410XQ54 LUCA
HOGENOMiHOG000230659
HOVERGENiHBG051586
InParanoidiQ9QZH7
KOiK10268
OrthoDBiEOG091G060Y
PhylomeDBiQ9QZH7

Miscellaneous databases

PROiPR:Q9QZH7

Gene expression databases

GenevisibleiQ9QZH7 RN

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 3 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 7 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFXL20_RAT
AccessioniPrimary (citable) accession number: Q9QZH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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