Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coatomer subunit gamma-1

Gene

Copg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-1
Alternative name(s):
Gamma-1-coat protein
Short name:
Gamma-1-COP
Gene namesi
Name:Copg1
Synonyms:Copg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1858696 Copg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049391 – 874Coatomer subunit gamma-1Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QZE5
MaxQBiQ9QZE5
PaxDbiQ9QZE5
PeptideAtlasiQ9QZE5
PRIDEiQ9QZE5

PTM databases

iPTMnetiQ9QZE5
PhosphoSitePlusiQ9QZE5
SwissPalmiQ9QZE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000030058 Expressed in 329 organ(s), highest expression level in pituitary gland
CleanExiMM_COPG
ExpressionAtlasiQ9QZE5 baseline and differential
GenevisibleiQ9QZE5 MM

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain (By similarity). Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER (By similarity). Interacts with COPB1 (By similarity). Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207587, 2 interactors
CORUMiQ9QZE5
IntActiQ9QZE5, 1 interactor
MINTiQ9QZE5
STRINGi10090.ENSMUSP00000109237

Structurei

3D structure databases

ProteinModelPortaliQ9QZE5
SMRiQ9QZE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 101HEAT 1Add BLAST38
Repeati283 – 320HEAT 2Add BLAST38
Repeati322 – 355HEAT 3Add BLAST34
Repeati356 – 392HEAT 4Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni609 – 874Interaction with ZNF289/ARFGAP2By similarityAdd BLAST266

Sequence similaritiesi

Belongs to the COPG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1078 Eukaryota
COG5240 LUCA
GeneTreeiENSGT00390000016313
HOGENOMiHOG000184434
HOVERGENiHBG004368
InParanoidiQ9QZE5
KOiK17267
OMAiPVNARKC
OrthoDBiEOG091G0HWQ
PhylomeDBiQ9QZE5
TreeFamiTF300324

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.60.40.1480, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR032154 Coatomer_g_Cpla
IPR017106 Coatomer_gsu
IPR013040 Coatomer_gsu_app_Ig-like_dom
IPR037067 Coatomer_gsu_app_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10261 PTHR10261, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF16381 Coatomer_g_Cpla, 1 hit
PF08752 COP-gamma_platf, 1 hit
PIRSFiPIRSF037093 Coatomer_gamma_subunit, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QZE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKKFDKKDE ESGGGSNPLQ HLEKSAVLQE ARVFNETPIN PRKCAHILTK
60 70 80 90 100
ILYLINQGEH LGTTEATEAF FAMTKLFQSN DPTLRRMCYL TIKEMSCIAE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDNY RGPAVRALCQ ITDSTMLQAV ERYMKQAIVD
160 170 180 190 200
KVPSVSSSAL VSSLHLLKCS FDVVKRWVNE AQEAASSDNI MVQYHALGLL
210 220 230 240 250
YHVRKNDRLA VSKMISKFTR HGLKSPFAYC MMIRVASKQL EEEDGSRDSP
260 270 280 290 300
LFDFIESCLR NKHEMVVYEA ASAIVNLPGC SAKELAPAVS VLQLFCSSPK
310 320 330 340 350
AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLVTDSNRSI ATLAITTLLK
360 370 380 390 400
TGSESSIDRL MKQISSFMSE ISDEFKVVVV QAISALCQKY PRKHAVLMNF
410 420 430 440 450
LFTMLREEGG FEYKRAIVDC IISIIEENSE SKETGLSHLC EFIEDCEFTV
460 470 480 490 500
LATRILHLLG QEGPKTNNPS KYIRFIYNRV VLEHEEVRAG AVSALAKFGA
510 520 530 540 550
QNEEMLPSIL VLLKRCVMDD DNEVRDRATF YLNVLEQKQK ALNAGYILNG
560 570 580 590 600
LTVSIPGLEK ALQQYTLEPS EKPFDLKSVP LATTPMAEQR PESTATAAVK
610 620 630 640 650
QPEKVAATRQ EIFQEQLAAV PEFQGLGPLF KSSPEPVALT ESETEYVIRC
660 670 680 690 700
TKHTFSDHLV FQFDCTNTLN DQTLENVTVQ MEPTEAYEVL SYVPARSLPY
710 720 730 740 750
NQPGTCYTLV ALPTEDPTAV ACTFSCVMKF TVKDCDPNTG EIDEEGYEDE
760 770 780 790 800
YVLEDLEVTV ADHIQKVMKV NFEAAWDEVG DEFEKEETFT LSTIKTLEEA
810 820 830 840 850
VGNIVKFLGM HPCERSDKVP ENKNTHTLLL AGVFRGGHDI LVRSRLLLLD
860 870
TVTMQVTARS SEELPVDIIL ASVG
Length:874
Mass (Da):97,513
Last modified:May 1, 2000 - v1
Checksum:iCAF3201AD1118728
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TNQ1Q7TNQ1_MOUSE
Coatomer protein complex, subunit g...
Copg1 Copg
121Annotation score:

Sequence cautioni

The sequence BAC36811 differs from that shown. Reason: Frameshift at position 864.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti811H → P in AAH24896 (PubMed:15489334).Curated1
Sequence conflicti841L → F in BAE31753 (PubMed:16141072).Curated1
Sequence conflicti841L → F in BAE30713 (PubMed:16141072).Curated1
Sequence conflicti841L → F in BAE30269 (PubMed:16141072).Curated1
Sequence conflicti843R → H in BAC36811 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187079 mRNA Translation: AAF01325.1
AK049417 mRNA Translation: BAC33743.1
AK077461 mRNA Translation: BAC36811.1 Frameshift.
AK147895 mRNA Translation: BAE28212.1
AK151284 mRNA Translation: BAE30269.1
AK151816 mRNA Translation: BAE30713.1
AK153142 mRNA Translation: BAE31753.1
AK164280 mRNA Translation: BAE37716.1
AK169256 mRNA Translation: BAE41019.1
AK171950 mRNA Translation: BAE42743.1
AK172519 mRNA Translation: BAE43046.1
BC008553 mRNA Translation: AAH08553.1
BC024686 mRNA Translation: AAH24686.1
BC024896 mRNA Translation: AAH24896.1
CCDSiCCDS39549.1
RefSeqiNP_059505.1, NM_017477.2
UniGeneiMm.258785

Genome annotation databases

EnsembliENSMUST00000113607; ENSMUSP00000109237; ENSMUSG00000030058
GeneIDi54161
KEGGimmu:54161
UCSCiuc009cug.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187079 mRNA Translation: AAF01325.1
AK049417 mRNA Translation: BAC33743.1
AK077461 mRNA Translation: BAC36811.1 Frameshift.
AK147895 mRNA Translation: BAE28212.1
AK151284 mRNA Translation: BAE30269.1
AK151816 mRNA Translation: BAE30713.1
AK153142 mRNA Translation: BAE31753.1
AK164280 mRNA Translation: BAE37716.1
AK169256 mRNA Translation: BAE41019.1
AK171950 mRNA Translation: BAE42743.1
AK172519 mRNA Translation: BAE43046.1
BC008553 mRNA Translation: AAH08553.1
BC024686 mRNA Translation: AAH24686.1
BC024896 mRNA Translation: AAH24896.1
CCDSiCCDS39549.1
RefSeqiNP_059505.1, NM_017477.2
UniGeneiMm.258785

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A1Uelectron microscopy13.00E1-874[»]
5A1Velectron microscopy21.00E/M/V1-874[»]
5A1Welectron microscopy18.00E1-874[»]
5A1Xelectron microscopy23.00E/M1-874[»]
5A1Yelectron microscopy21.00E/M/V1-874[»]
5NZRelectron microscopy9.20G/K1-874[»]
5NZSelectron microscopy10.10G/K1-874[»]
5NZTelectron microscopy17.00G/K1-874[»]
5NZUelectron microscopy15.00G/K1-874[»]
5NZVelectron microscopy17.30G/K/Q1-874[»]
ProteinModelPortaliQ9QZE5
SMRiQ9QZE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207587, 2 interactors
CORUMiQ9QZE5
IntActiQ9QZE5, 1 interactor
MINTiQ9QZE5
STRINGi10090.ENSMUSP00000109237

PTM databases

iPTMnetiQ9QZE5
PhosphoSitePlusiQ9QZE5
SwissPalmiQ9QZE5

Proteomic databases

EPDiQ9QZE5
MaxQBiQ9QZE5
PaxDbiQ9QZE5
PeptideAtlasiQ9QZE5
PRIDEiQ9QZE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113607; ENSMUSP00000109237; ENSMUSG00000030058
GeneIDi54161
KEGGimmu:54161
UCSCiuc009cug.1 mouse

Organism-specific databases

CTDi22820
MGIiMGI:1858696 Copg1

Phylogenomic databases

eggNOGiKOG1078 Eukaryota
COG5240 LUCA
GeneTreeiENSGT00390000016313
HOGENOMiHOG000184434
HOVERGENiHBG004368
InParanoidiQ9QZE5
KOiK17267
OMAiPVNARKC
OrthoDBiEOG091G0HWQ
PhylomeDBiQ9QZE5
TreeFamiTF300324

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiCopg1 mouse
PROiPR:Q9QZE5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030058 Expressed in 329 organ(s), highest expression level in pituitary gland
CleanExiMM_COPG
ExpressionAtlasiQ9QZE5 baseline and differential
GenevisibleiQ9QZE5 MM

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.60.40.1480, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR032154 Coatomer_g_Cpla
IPR017106 Coatomer_gsu
IPR013040 Coatomer_gsu_app_Ig-like_dom
IPR037067 Coatomer_gsu_app_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10261 PTHR10261, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF16381 Coatomer_g_Cpla, 1 hit
PF08752 COP-gamma_platf, 1 hit
PIRSFiPIRSF037093 Coatomer_gamma_subunit, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPG1_MOUSE
AccessioniPrimary (citable) accession number: Q9QZE5
Secondary accession number(s): Q3U9F4
, Q8BP96, Q8R1A7, Q922C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again