UniProtKB - Q9QZD8 (DIC_MOUSE)
Protein
Mitochondrial dicarboxylate carrier
Gene
Slc25a10
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
GO - Molecular functioni
- antiporter activity Source: MGI
- malate transmembrane transporter activity Source: MGI
- oxaloacetate transmembrane transporter activity Source: GO_Central
- phosphate ion transmembrane transporter activity Source: MGI
- secondary active transmembrane transporter activity Source: MGI
- succinate transmembrane transporter activity Source: MGI
- sulfate transmembrane transporter activity Source: MGI
- thiosulfate transmembrane transporter activity Source: MGI
GO - Biological processi
- malate transmembrane transport Source: GO_Central
- malate transport Source: MGI
- mitochondrial transport Source: MGI
- oxaloacetate transport Source: GO_Central
- phosphate ion transmembrane transport Source: GO_Central
- phosphate ion transport Source: MGI
- succinate transmembrane transport Source: GO_Central
- succinate transport Source: MGI
- sulfate transport Source: MGI
- thiosulfate transport Source: MGI
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-MMU-1614517, Sulfide oxidation to sulfate R-MMU-428643, Organic anion transporters R-MMU-70263, Gluconeogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial dicarboxylate carrierAlternative name(s): Solute carrier family 25 member 10 |
Gene namesi | Name:Slc25a10 Synonyms:Dic |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353497, Slc25a10 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: MGI
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 9 – 29 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 62 – 81 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 162 – 181 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Transmembranei | 202 – 222 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 254 – 274 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090610 | 1 – 287 | Mitochondrial dicarboxylate carrierAdd BLAST | 287 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 158 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9QZD8 |
jPOSTi | Q9QZD8 |
MaxQBi | Q9QZD8 |
PaxDbi | Q9QZD8 |
PeptideAtlasi | Q9QZD8 |
PRIDEi | Q9QZD8 |
PTM databases
iPTMneti | Q9QZD8 |
PhosphoSitePlusi | Q9QZD8 |
SwissPalmi | Q9QZD8 |
Expressioni
Tissue specificityi
Expressed at very high levels in white adipocytes.
Gene expression databases
Bgeei | ENSMUSG00000025792, Expressed in cortex of kidney and 295 other tissues |
Genevisiblei | Q9QZD8, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 205183, 8 interactors |
IntActi | Q9QZD8, 3 interactors |
MINTi | Q9QZD8 |
STRINGi | 10090.ENSMUSP00000026899 |
Miscellaneous databases
RNActi | Q9QZD8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 87 | Solcar 1Add BLAST | 81 | |
Repeati | 100 – 187 | Solcar 2Add BLAST | 88 | |
Repeati | 196 – 279 | Solcar 3Add BLAST | 84 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0759, Eukaryota |
GeneTreei | ENSGT00940000156783 |
HOGENOMi | CLU_015166_14_1_1 |
InParanoidi | Q9QZD8 |
OMAi | FGAYEVG |
OrthoDBi | 984118at2759 |
PhylomeDBi | Q9QZD8 |
TreeFami | TF312920 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q9QZD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEARASRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV
60 70 80 90 100
VRTDGFLALY NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYN
110 120 130 140 150
KVLLGGISGL TGGFVGTPAD LVNVRMQNDM KLPPSQRRNY SHALDGLYRV
160 170 180 190 200
AREESLRKLF SGATMASSRG ALVTVGQLSC YDQAKQLVLS TGYLSDNIFT
210 220 230 240 250
HFVSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA METAKLGPQA
260 270 280
FFKGLFPAGI RLIPHTVLTF MFLEQLRKHF GIKVPTT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | A → T in AAF03412 (PubMed:10567211).Curated | 1 | |
Sequence conflicti | 46 | M → L in AAF03412 (PubMed:10567211).Curated | 1 | |
Sequence conflicti | 78 | F → L in BAB25425 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF188712 mRNA Translation: AAF03412.1 AK008038 mRNA Translation: BAB25425.1 AK050282 mRNA Translation: BAC34165.1 AK151645 mRNA Translation: BAE30575.1 BC003222 mRNA Translation: AAH03222.1 |
CCDSi | CCDS25738.1 |
RefSeqi | NP_038798.2, NM_013770.2 |
Genome annotation databases
Ensembli | ENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792 |
GeneIDi | 27376 |
KEGGi | mmu:27376 |
UCSCi | uc007mtb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF188712 mRNA Translation: AAF03412.1 AK008038 mRNA Translation: BAB25425.1 AK050282 mRNA Translation: BAC34165.1 AK151645 mRNA Translation: BAE30575.1 BC003222 mRNA Translation: AAH03222.1 |
CCDSi | CCDS25738.1 |
RefSeqi | NP_038798.2, NM_013770.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 205183, 8 interactors |
IntActi | Q9QZD8, 3 interactors |
MINTi | Q9QZD8 |
STRINGi | 10090.ENSMUSP00000026899 |
PTM databases
iPTMneti | Q9QZD8 |
PhosphoSitePlusi | Q9QZD8 |
SwissPalmi | Q9QZD8 |
Proteomic databases
EPDi | Q9QZD8 |
jPOSTi | Q9QZD8 |
MaxQBi | Q9QZD8 |
PaxDbi | Q9QZD8 |
PeptideAtlasi | Q9QZD8 |
PRIDEi | Q9QZD8 |
Genome annotation databases
Ensembli | ENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792 |
GeneIDi | 27376 |
KEGGi | mmu:27376 |
UCSCi | uc007mtb.2, mouse |
Organism-specific databases
CTDi | 1468 |
MGIi | MGI:1353497, Slc25a10 |
Phylogenomic databases
eggNOGi | KOG0759, Eukaryota |
GeneTreei | ENSGT00940000156783 |
HOGENOMi | CLU_015166_14_1_1 |
InParanoidi | Q9QZD8 |
OMAi | FGAYEVG |
OrthoDBi | 984118at2759 |
PhylomeDBi | Q9QZD8 |
TreeFami | TF312920 |
Enzyme and pathway databases
Reactomei | R-MMU-1614517, Sulfide oxidation to sulfate R-MMU-428643, Organic anion transporters R-MMU-70263, Gluconeogenesis |
Miscellaneous databases
BioGRID-ORCSi | 27376, 3 hits in 17 CRISPR screens |
ChiTaRSi | Slc25a10, mouse |
PROi | PR:Q9QZD8 |
RNActi | Q9QZD8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025792, Expressed in cortex of kidney and 295 other tissues |
Genevisiblei | Q9QZD8, MM |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DIC_MOUSE | |
Accessioni | Q9QZD8Primary (citable) accession number: Q9QZD8 Secondary accession number(s): Q543J6, Q99LJ9, Q9D8G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | February 11, 2002 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families