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Protein

Mitochondrial dicarboxylate carrier

Gene

Slc25a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-1614517 Sulfide oxidation to sulfate
R-MMU-428643 Organic anion transporters
R-MMU-70263 Gluconeogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial dicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 10
Gene namesi
Name:Slc25a10
Synonyms:Dic
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353497 Slc25a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei62 – 81Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei162 – 181Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906101 – 287Mitochondrial dicarboxylate carrierAdd BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QZD8
MaxQBiQ9QZD8
PaxDbiQ9QZD8
PeptideAtlasiQ9QZD8
PRIDEiQ9QZD8

PTM databases

iPTMnetiQ9QZD8
PhosphoSitePlusiQ9QZD8
SwissPalmiQ9QZD8

Expressioni

Tissue specificityi

Expressed at very high levels in white adipocytes.

Gene expression databases

BgeeiENSMUSG00000025792
GenevisibleiQ9QZD8 MM

Interactioni

Protein-protein interaction databases

BioGridi205183, 3 interactors
IntActiQ9QZD8, 3 interactors
MINTiQ9QZD8
STRINGi10090.ENSMUSP00000026899

Structurei

3D structure databases

ProteinModelPortaliQ9QZD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 87Solcar 1Add BLAST81
Repeati100 – 187Solcar 2Add BLAST88
Repeati196 – 279Solcar 3Add BLAST84

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759 Eukaryota
ENOG410XQHU LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165139
HOVERGENiHBG009528
InParanoidiQ9QZD8
KOiK13577
OMAiLKTRAMN
OrthoDBiEOG091G0BQ7
PhylomeDBiQ9QZD8
TreeFamiTF312920

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9QZD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARASRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV
60 70 80 90 100
VRTDGFLALY NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYN
110 120 130 140 150
KVLLGGISGL TGGFVGTPAD LVNVRMQNDM KLPPSQRRNY SHALDGLYRV
160 170 180 190 200
AREESLRKLF SGATMASSRG ALVTVGQLSC YDQAKQLVLS TGYLSDNIFT
210 220 230 240 250
HFVSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA METAKLGPQA
260 270 280
FFKGLFPAGI RLIPHTVLTF MFLEQLRKHF GIKVPTT
Length:287
Mass (Da):31,715
Last modified:February 11, 2002 - v2
Checksum:iE351D1CE18E5B568
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → T in AAF03412 (PubMed:10567211).Curated1
Sequence conflicti46M → L in AAF03412 (PubMed:10567211).Curated1
Sequence conflicti78F → L in BAB25425 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188712 mRNA Translation: AAF03412.1
AK008038 mRNA Translation: BAB25425.1
AK050282 mRNA Translation: BAC34165.1
AK151645 mRNA Translation: BAE30575.1
BC003222 mRNA Translation: AAH03222.1
CCDSiCCDS25738.1
RefSeqiNP_038798.2, NM_013770.2
UniGeneiMm.3991

Genome annotation databases

EnsembliENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792
GeneIDi27376
KEGGimmu:27376
UCSCiuc007mtb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDIC_MOUSE
AccessioniPrimary (citable) accession number: Q9QZD8
Secondary accession number(s): Q543J6, Q99LJ9, Q9D8G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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