Slc25a10

Functionⁱ

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

GO - Molecular functionⁱ

antiporter activity Source: MGI
malate transmembrane transporter activity Source: MGI
oxaloacetate transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
phosphate ion transmembrane transporter activity Source: MGI
secondary active transmembrane transporter activity
Source: MGI
Inferred from direct assayⁱ
- Ref.1
  "Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue."
  Das K., Lewis R.Y., Combatsiaris T.P., Lin Y., Shapiro L., Charron M.J., Scherer P.E.
  Biochem. J. 344:313-320(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA].
succinate transmembrane transporter activity Source: MGI
sulfate transmembrane transporter activity Source: MGI
thiosulfate transmembrane transporter activity Source: MGI

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1614517, Sulfide oxidation to sulfate R-MMU-428643, Organic anion transporters R-MMU-70263, Gluconeogenesis

Reactomeⁱ

R-MMU-1614517, Sulfide oxidation to sulfate
R-MMU-428643, Organic anion transporters
R-MMU-70263, Gluconeogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial dicarboxylate carrier Alternative name(s): Solute carrier family 25 member 10
Gene namesⁱ	Name:Slc25a10 Synonyms:Dic
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1353497, Slc25a10

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	9 – 29	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	62 – 81	Helical; Name=2Sequence analysisAdd BLAST	20
Transmembraneⁱ	102 – 122	Helical; Name=3Sequence analysisAdd BLAST	21
Transmembraneⁱ	162 – 181	Helical; Name=4Sequence analysisAdd BLAST	20
Transmembraneⁱ	202 – 222	Helical; Name=5Sequence analysisAdd BLAST	21
Transmembraneⁱ	254 – 274	Helical; Name=6Sequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090610	1 – 287	Mitochondrial dicarboxylate carrierAdd BLAST		287

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	158	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9QZD8
jPOSTⁱ	Q9QZD8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9QZD8
PaxDbⁱ	Q9QZD8
PeptideAtlas More...PeptideAtlasⁱ	Q9QZD8
PRIDEⁱ	Q9QZD8

PTM databases

iPTMnetⁱ	Q9QZD8
PhosphoSitePlusⁱ	Q9QZD8
SwissPalmⁱ	Q9QZD8

Expressionⁱ

Tissue specificityⁱ

Expressed at very high levels in white adipocytes.

Gene expression databases

Bgeeⁱ	ENSMUSG00000025792, Expressed in cortex of kidney and 295 other tissues
Genevisibleⁱ	Q9QZD8, MM

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	205183, 8 interactors
IntActⁱ	Q9QZD8, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9QZD8
STRINGⁱ	10090.ENSMUSP00000026899

Miscellaneous databases

RNActⁱ	Q9QZD8, protein

RNActⁱ

Q9QZD8, protein

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	7 – 87	Solcar 1Add BLAST	81
Repeatⁱ	100 – 187	Solcar 2Add BLAST	88
Repeatⁱ	196 – 279	Solcar 3Add BLAST	84

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0759, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156783
HOGENOMⁱ	CLU_015166_14_1_1
InParanoidⁱ	Q9QZD8
OMAⁱ	FGAYEVG
Database of Orthologous Groups More...OrthoDBⁱ	984118at2759
PhylomeDBⁱ	Q9QZD8
TreeFamⁱ	TF312920

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153, Mito_carr, 3 hits
PRINTSⁱ	PR00784, MTUNCOUPLING
SUPFAMⁱ	SSF103506, SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920, SOLCAR, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9QZD8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEARASRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV 
        60         70         80         90        100
VRTDGFLALY NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYN 
       110        120        130        140        150
KVLLGGISGL TGGFVGTPAD LVNVRMQNDM KLPPSQRRNY SHALDGLYRV 
       160        170        180        190        200
AREESLRKLF SGATMASSRG ALVTVGQLSC YDQAKQLVLS TGYLSDNIFT 
       210        220        230        240        250
HFVSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA METAKLGPQA 
       260        270        280 
FFKGLFPAGI RLIPHTVLTF MFLEQLRKHF GIKVPTT

Length:287

Mass (Da):31,715

Last modified:February 11, 2002 - v2

Checksum:ⁱE351D1CE18E5B568

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	A → T in AAF03412 (PubMed:10567211).Curated	1
Sequence conflictⁱ	46	M → L in AAF03412 (PubMed:10567211).Curated	1
Sequence conflictⁱ	78	F → L in BAB25425 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF188712 mRNA Translation: AAF03412.1 AK008038 mRNA Translation: BAB25425.1 AK050282 mRNA Translation: BAC34165.1 AK151645 mRNA Translation: BAE30575.1 BC003222 mRNA Translation: AAH03222.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25738.1
NCBI Reference Sequences More...RefSeqⁱ	NP_038798.2, NM_013770.2

Genome annotation databases

Ensemblⁱ	ENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792
GeneIDⁱ	27376
KEGGⁱ	mmu:27376
UCSC genome browser More...UCSCⁱ	uc007mtb.2, mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QZD8	mitochondrial dicarboxylate carrier		MUSCR		286	UniRef90_Q9QZD8
Mitochondrial dicarboxylate carrier		RAT		286
mitochondrial dicarboxylate carrier isoform X1		MESAU		286
mitochondrial dicarboxylate carrier isoform X2		PERMB		267
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9QZD8	Mitochondrial dicarboxylate carrier		RAT		286	UniRef50_Q9QZD8
mitochondrial dicarboxylate carrier		MUSCR		286
mitochondrial dicarboxylate carrier isoform X1		MESAU		286
mitochondrial dicarboxylate carrier isoform X2		PERMB		267
mitochondrial dicarboxylate carrier		ALLSI		258
+217

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF188712 mRNA Translation: AAF03412.1 AK008038 mRNA Translation: BAB25425.1 AK050282 mRNA Translation: BAC34165.1 AK151645 mRNA Translation: BAE30575.1 BC003222 mRNA Translation: AAH03222.1
CCDSⁱ	CCDS25738.1
RefSeqⁱ	NP_038798.2, NM_013770.2

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

BioGRIDⁱ	205183, 8 interactors
IntActⁱ	Q9QZD8, 3 interactors
MINTⁱ	Q9QZD8
STRINGⁱ	10090.ENSMUSP00000026899

PTM databases

iPTMnetⁱ	Q9QZD8
PhosphoSitePlusⁱ	Q9QZD8
SwissPalmⁱ	Q9QZD8

Proteomic databases

EPDⁱ	Q9QZD8
jPOSTⁱ	Q9QZD8
MaxQBⁱ	Q9QZD8
PaxDbⁱ	Q9QZD8
PeptideAtlasⁱ	Q9QZD8
PRIDEⁱ	Q9QZD8

Genome annotation databases

Ensemblⁱ	ENSMUST00000026899; ENSMUSP00000026899; ENSMUSG00000025792
GeneIDⁱ	27376
KEGGⁱ	mmu:27376
UCSCⁱ	uc007mtb.2, mouse

Organism-specific databases

CTDⁱ	1468
MGIⁱ	MGI:1353497, Slc25a10

Phylogenomic databases

eggNOGⁱ	KOG0759, Eukaryota
GeneTreeⁱ	ENSGT00940000156783
HOGENOMⁱ	CLU_015166_14_1_1
InParanoidⁱ	Q9QZD8
OMAⁱ	FGAYEVG
OrthoDBⁱ	984118at2759
PhylomeDBⁱ	Q9QZD8
TreeFamⁱ	TF312920

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1614517, Sulfide oxidation to sulfate R-MMU-428643, Organic anion transporters R-MMU-70263, Gluconeogenesis

Reactomeⁱ

R-MMU-1614517, Sulfide oxidation to sulfate
R-MMU-428643, Organic anion transporters
R-MMU-70263, Gluconeogenesis

Miscellaneous databases

BioGRID-ORCSⁱ	27376, 3 hits in 17 CRISPR screens
ChiTaRSⁱ	Slc25a10, mouse
Protein Ontology More...PROⁱ	PR:Q9QZD8
RNActⁱ	Q9QZD8, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025792, Expressed in cortex of kidney and 295 other tissues
Genevisibleⁱ	Q9QZD8, MM

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf
Pfamⁱ	View protein in Pfam PF00153, Mito_carr, 3 hits
PRINTSⁱ	PR00784, MTUNCOUPLING
SUPFAMⁱ	SSF103506, SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920, SOLCAR, 3 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DIC_MOUSE
Accessionⁱ	Q9QZD8Primary (citable) accession number: Q9QZD8 Secondary accession number(s): Q543J6, Q99LJ9, Q9D8G8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	February 11, 2002
	Last modified:	December 2, 2020
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QZD8 (DIC_MOUSE)

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Mitochondrial dicarboxylate carrier

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ