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Protein

Short transient receptor potential channel 3

Gene

Trpc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 3
Short name:
TrpC3
Alternative name(s):
Receptor-activated cation channel TRP3
Transient receptor protein 3
Short name:
TRP-3
Short name:
mTrp3
Trp-related protein 3
Gene namesi
Name:Trpc3
Synonyms:Trp3, Trrp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109526 Trpc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 369CytoplasmicSequence analysisAdd BLAST369
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 418ExtracellularSequence analysisAdd BLAST28
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 451CytoplasmicSequence analysisAdd BLAST12
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 523ExtracellularSequence analysisAdd BLAST51
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 567CytoplasmicSequence analysisAdd BLAST23
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Topological domaini589 – 637ExtracellularSequence analysisAdd BLAST49
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 836CytoplasmicSequence analysisAdd BLAST178

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153111 – 836Short transient receptor potential channel 3Add BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QZC1
PaxDbiQ9QZC1
PRIDEiQ9QZC1

PTM databases

iPTMnetiQ9QZC1
PhosphoSitePlusiQ9QZC1

Expressioni

Tissue specificityi

Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues.

Interactioni

Subunit structurei

Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation (By similarity).By similarity

Protein-protein interaction databases

CORUMiQ9QZC1
DIPiDIP-61309N
IntActiQ9QZC1, 3 interactors
STRINGi10090.ENSMUSP00000029271

Structurei

3D structure databases

ProteinModelPortaliQ9QZC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 55ANK 1Add BLAST30
Repeati61 – 90ANK 2Add BLAST30
Repeati92 – 118ANK 3Add BLAST27
Repeati147 – 176ANK 4Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
HOVERGENiHBG068337
InParanoidiQ9QZC1

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005459 TRPC3_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF8 PTHR10117:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01644 TRPCHANNEL3
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9QZC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDKGRRQAV RGPAFMFGAR GPSLTAEEER FLDAAEYGNI PVVRKMLEES
60 70 80 90 100
RTLNVNCVDY MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK
110 120 130 140 150
GYVRIVEAIL GHPGFAASRR LTLSPCEQEL RDDDFYAYDE DGTRFSPDIT
160 170 180 190 200
PIILAAHCHK YEVVHLLLLK GARIERAHDY FCRCSDCAEK QRLDAFSHSR
210 220 230 240 250
SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE KEFKNDYRKL
260 270 280 290 300
SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLERHGH KASLSRVKLA
310 320 330 340 350
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF
360 370 380 390 400
LAIGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT
410 420 430 440 450
TLPNITVIDY PKQIFRVKTT QFTWTEMLIM VWVLGMMWSE CKELWLEGPR
460 470 480 490 500
EYIVQLWNVL DFGMLSIFIA AFTARFLAFL QATKAQQYVD SHVQESDLSE
510 520 530 540 550
VTLPPEVQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES
560 570 580 590 600
FGPLQISLGR TVKDIFKFMV LFIMVFLAFM IGMFILYSYY LGAKVNPAFT
610 620 630 640 650
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL
660 670 680 690 700
LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS
710 720 730 740 750
PKSFVYFIMR ITNFSKCRRR RLQKDLELGM GNSKSRLNLF TQSNSRVFES
760 770 780 790 800
HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS
810 820 830
SLRYELLEDK SQATEELAIL IHKLSEKLNP SVLRCE
Length:836
Mass (Da):95,672
Last modified:May 1, 2000 - v1
Checksum:i7B863B209B9A25F8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ATV3B1ATV3_MOUSE
Short transient receptor potential ...
Trpc3 CT7-314H19.1-001, mCG_14063
910Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190645 mRNA Translation: AAF01468.1
U40982 mRNA Translation: AAC52701.1
UniGeneiMm.74363

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190645 mRNA Translation: AAF01468.1
U40982 mRNA Translation: AAC52701.1
UniGeneiMm.74363

3D structure databases

ProteinModelPortaliQ9QZC1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ9QZC1
DIPiDIP-61309N
IntActiQ9QZC1, 3 interactors
STRINGi10090.ENSMUSP00000029271

PTM databases

iPTMnetiQ9QZC1
PhosphoSitePlusiQ9QZC1

Proteomic databases

MaxQBiQ9QZC1
PaxDbiQ9QZC1
PRIDEiQ9QZC1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109526 Trpc3

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
HOVERGENiHBG068337
InParanoidiQ9QZC1

Miscellaneous databases

ChiTaRSiTrpc3 mouse
PROiPR:Q9QZC1
SOURCEiSearch...

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005459 TRPC3_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF8 PTHR10117:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01644 TRPCHANNEL3
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZC1
Secondary accession number(s): Q61058
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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