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Protein

Dynactin subunit 5

Gene

Dctn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • aorta development Source: MGI
  • coronary vasculature development Source: MGI
  • ventricular septum development Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 5
Alternative name(s):
Dynactin subunit p25
Gene namesi
Name:Dctn5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891689 Dctn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798281 – 182Dynactin subunit 5Add BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QZB9
MaxQBiQ9QZB9
PaxDbiQ9QZB9
PeptideAtlasiQ9QZB9
PRIDEiQ9QZB9

PTM databases

iPTMnetiQ9QZB9
PhosphoSitePlusiQ9QZB9

Expressioni

Gene expression databases

BgeeiENSMUSG00000030868 Expressed in 298 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ9QZB9 baseline and differential
GenevisibleiQ9QZB9 MM

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.1 Publication

Protein-protein interaction databases

BioGridi208544, 18 interactors
IntActiQ9QZB9, 19 interactors
MINTiQ9QZB9
STRINGi10090.ENSMUSP00000033156

Structurei

3D structure databases

ProteinModelPortaliQ9QZB9
SMRiQ9QZB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3121 Eukaryota
ENOG410YENR LUCA
GeneTreeiENSGT00390000015360
HOGENOMiHOG000198229
HOVERGENiHBG051325
InParanoidiQ9QZB9
KOiK10427
OMAiGNFNYYP
OrthoDBiEOG091G0NK3
PhylomeDBiQ9QZB9
TreeFamiTF314194

Family and domain databases

InterProiView protein in InterPro
IPR001451 Hexapep
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QZB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELGELLYNK SEYIETASGN KVSRQSVLCG SQNIVLNGKT IIMNDCIIRG
60 70 80 90 100
DLANVRVGRH CVVKSRSVIR PPFKKFSKGV AFFPLHIGDH VFIEEDCVVN
110 120 130 140 150
AAQIGSYVHV GKNCVIGRRC VLKDCCKILD NTVLPPETVV PPFTVFSGCP
160 170 180
GLFSGELPEC TQELMIDVTK SYYQKFLPLT QV
Length:182
Mass (Da):20,141
Last modified:May 1, 2000 - v1
Checksum:i476DAB4B7805D496
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJ75H3BJ75_MOUSE
Dynactin subunit 5
Dctn5
54Annotation score:
H3BKU6H3BKU6_MOUSE
Dynactin subunit 5
Dctn5
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11S → L in AAH10834 (PubMed:15489334).Curated1
Sequence conflicti95E → G in BAC36183 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190795 mRNA Translation: AAF05615.1
AK010238 mRNA Translation: BAB26789.1
AK051957 mRNA Translation: BAC34820.1
AK076100 mRNA Translation: BAC36183.1
AK076738 mRNA Translation: BAC36460.1
AK151193 mRNA Translation: BAE30190.1
AK151876 mRNA Translation: BAE30763.1
AK168983 mRNA Translation: BAE40783.1
BC010834 mRNA Translation: AAH10834.1
BC005671 mRNA Translation: AAH05671.1
CCDSiCCDS21811.1
RefSeqiNP_067621.3, NM_021608.3
UniGeneiMm.478285

Genome annotation databases

EnsembliENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868
GeneIDi59288
KEGGimmu:59288
UCSCiuc009jon.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190795 mRNA Translation: AAF05615.1
AK010238 mRNA Translation: BAB26789.1
AK051957 mRNA Translation: BAC34820.1
AK076100 mRNA Translation: BAC36183.1
AK076738 mRNA Translation: BAC36460.1
AK151193 mRNA Translation: BAE30190.1
AK151876 mRNA Translation: BAE30763.1
AK168983 mRNA Translation: BAE40783.1
BC010834 mRNA Translation: AAH10834.1
BC005671 mRNA Translation: AAH05671.1
CCDSiCCDS21811.1
RefSeqiNP_067621.3, NM_021608.3
UniGeneiMm.478285

3D structure databases

ProteinModelPortaliQ9QZB9
SMRiQ9QZB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208544, 18 interactors
IntActiQ9QZB9, 19 interactors
MINTiQ9QZB9
STRINGi10090.ENSMUSP00000033156

PTM databases

iPTMnetiQ9QZB9
PhosphoSitePlusiQ9QZB9

Proteomic databases

EPDiQ9QZB9
MaxQBiQ9QZB9
PaxDbiQ9QZB9
PeptideAtlasiQ9QZB9
PRIDEiQ9QZB9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033156; ENSMUSP00000033156; ENSMUSG00000030868
GeneIDi59288
KEGGimmu:59288
UCSCiuc009jon.2 mouse

Organism-specific databases

CTDi84516
MGIiMGI:1891689 Dctn5

Phylogenomic databases

eggNOGiKOG3121 Eukaryota
ENOG410YENR LUCA
GeneTreeiENSGT00390000015360
HOGENOMiHOG000198229
HOVERGENiHBG051325
InParanoidiQ9QZB9
KOiK10427
OMAiGNFNYYP
OrthoDBiEOG091G0NK3
PhylomeDBiQ9QZB9
TreeFamiTF314194

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:Q9QZB9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030868 Expressed in 298 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ9QZB9 baseline and differential
GenevisibleiQ9QZB9 MM

Family and domain databases

InterProiView protein in InterPro
IPR001451 Hexapep
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN5_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB9
Secondary accession number(s): Q3U9A4
, Q8BPE5, Q91XC6, Q99J17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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