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Protein

Regulator of G-protein signaling 20

Gene

Rgs20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.3 Publications

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 20
Short name:
RGS20
Alternative name(s):
Regulator of G-protein signaling Z1
Gene namesi
Name:Rgs20
Synonyms:Rgsz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929866 Rgs20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042341 – 239Regulator of G-protein signaling 20Add BLAST239

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
N- and O-glycosylated in synapsomal membranes.1 Publication
Serine phosphorylated in synapsomal membranes.1 Publication
Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation increases binding to the G-proteins, G(alpha)-i2 and G(z), and interaction with mu-opioid receptors.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9QZB1
PeptideAtlasiQ9QZB1
PRIDEiQ9QZB1

PTM databases

iPTMnetiQ9QZB1
PhosphoSitePlusiQ9QZB1
SwissPalmiQ9QZB1

Expressioni

Gene expression databases

BgeeiENSMUSG00000002459 Expressed in 143 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_RGS20
ExpressionAtlasiQ9QZB1 baseline and differential
GenevisibleiQ9QZB1 MM

Interactioni

Subunit structurei

Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi208369, 1 interactor
IntActiQ9QZB1, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9QZB1
SMRiQ9QZB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 229RGSPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 71Poly-CysAdd BLAST13

Phylogenomic databases

GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ9QZB1
KOiK16449
PhylomeDBiQ9QZB1

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9QZB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTANGGPRA RASPSASPAD PGLPEGSERT EMRMRQMCGG SETQGPAPSQ
60 70 80 90 100
QGGRGSNACC FCWCCCCTCS CLTVRNQEDQ RPQRASHEIR TDIPACEESP
110 120 130 140 150
TPTLEEVCAW AQSFDNLMVT PAGRNAFREF LRTEFSEENM LFWMACEELK
160 170 180 190 200
REANKSTIEE KARIIYEDYI SILSPKEVSL DSRVREVINR NMVDPSQHIF
210 220 230
DDAQLQIYTL MHRDSYPRFM NSTVYKDLLT SLAEKTVEA
Length:239
Mass (Da):26,986
Last modified:May 1, 2000 - v1
Checksum:iF383923163A44D18
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q720E9Q720_MOUSE
Regulator of G-protein-signaling 20
Rgs20
372Annotation score:
Q8C5J7Q8C5J7_MOUSE
Regulator of G-protein-signaling 20
Rgs20
208Annotation score:
D3Z4Z8D3Z4Z8_MOUSE
Regulator of G-protein-signaling 20
Rgs20
200Annotation score:
E9Q1A3E9Q1A3_MOUSE
Regulator of G-protein-signaling 20
Rgs20
39Annotation score:

Sequence cautioni

The sequence BAB28987 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti32M → R in strain: BALB/c. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191554 mRNA Translation: AAF05757.1
AF191552 mRNA Translation: AAF05756.1
AK013773 mRNA Translation: BAB28987.2 Different initiation.
AK158864 mRNA Translation: BAE34700.1
BC116925 mRNA Translation: AAI16926.1
BC116929 mRNA Translation: AAI16930.1
CCDSiCCDS14807.1
RefSeqiNP_001277301.1, NM_001290372.1
NP_067349.2, NM_021374.5
XP_011236702.1, XM_011238400.1
UniGeneiMm.103771

Genome annotation databases

EnsembliENSMUST00000002533; ENSMUSP00000002533; ENSMUSG00000002459
GeneIDi58175
KEGGimmu:58175
UCSCiuc007afk.3 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191554 mRNA Translation: AAF05757.1
AF191552 mRNA Translation: AAF05756.1
AK013773 mRNA Translation: BAB28987.2 Different initiation.
AK158864 mRNA Translation: BAE34700.1
BC116925 mRNA Translation: AAI16926.1
BC116929 mRNA Translation: AAI16930.1
CCDSiCCDS14807.1
RefSeqiNP_001277301.1, NM_001290372.1
NP_067349.2, NM_021374.5
XP_011236702.1, XM_011238400.1
UniGeneiMm.103771

3D structure databases

ProteinModelPortaliQ9QZB1
SMRiQ9QZB1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208369, 1 interactor
IntActiQ9QZB1, 1 interactor

PTM databases

iPTMnetiQ9QZB1
PhosphoSitePlusiQ9QZB1
SwissPalmiQ9QZB1

Proteomic databases

MaxQBiQ9QZB1
PeptideAtlasiQ9QZB1
PRIDEiQ9QZB1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002533; ENSMUSP00000002533; ENSMUSG00000002459
GeneIDi58175
KEGGimmu:58175
UCSCiuc007afk.3 mouse

Organism-specific databases

CTDi8601
MGIiMGI:1929866 Rgs20

Phylogenomic databases

GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ9QZB1
KOiK16449
PhylomeDBiQ9QZB1

Miscellaneous databases

PROiPR:Q9QZB1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002459 Expressed in 143 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_RGS20
ExpressionAtlasiQ9QZB1 baseline and differential
GenevisibleiQ9QZB1 MM

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS20_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB1
Secondary accession number(s): Q14A97
, Q3TY63, Q9CUV8, Q9QZB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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