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Protein

Regulator of G-protein signaling 17

Gene

Rgs17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.By similarity2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 17
Short name:
RGS17
Alternative name(s):
Regulator of Gz-selective protein signaling 2
Gene namesi
Name:Rgs17
Synonyms:Rgsz21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1927469 Rgs17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042251 – 210Regulator of G-protein signaling 17Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphotyrosineCombined sources1

Post-translational modificationi

N- and O-glycosylated in synapsomal membranes.1 Publication
Serine phosphorylated in synapsomal membranes.1 Publication
Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9QZB0
PaxDbiQ9QZB0
PRIDEiQ9QZB0

PTM databases

iPTMnetiQ9QZB0
PhosphoSitePlusiQ9QZB0

Expressioni

Tissue specificityi

Detected in brain (at protein level) (PubMed:15827571, PubMed:16900103). Highly expressed in the hypothalamus, periaqueductal gray matter, and pons-medulla. Lower levels in the thalamus, cortex and spinal cord. Weak expression in the striatum and cerebellum.2 Publications

Gene expression databases

BgeeiENSMUSG00000019775 Expressed in 171 organ(s), highest expression level in secondary oocyte
CleanExiMM_RGS17
ExpressionAtlasiQ9QZB0 baseline and differential
GenevisibleiQ9QZB0 MM

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAQ (By similarity). Interacts with GNAZ and GNAI2 (PubMed:15827571, PubMed:16900103). Interacts with OPRM1 (PubMed:15827571). Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (PubMed:15827571).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065825

Structurei

3D structure databases

ProteinModelPortaliQ9QZB0
SMRiQ9QZB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 200RGSPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 40Poly-CysAdd BLAST13

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ9QZB0
KOiK16449
OMAiCQNPTSD
PhylomeDBiQ9QZB0
TreeFamiTF315837

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QZB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKRQQSQNE GTQAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGD
60 70 80 90 100
SSGRSPHTTK MESIQVLEEC QNPTADEVLS WSQNFDKMMK TPAGRNLFRE
110 120 130 140 150
FLRTEYSEEN LLFWLACEDL KKEQNKKAVE EKARMIYEDY ISILSPKEVS
160 170 180 190 200
LDSRVREVIN RSLLDPSPHM YEDAQLQIYT LMHRDSFPRF LNSQIYKAFV
210
ESTTSCTSES
Length:210
Mass (Da):24,345
Last modified:May 1, 2000 - v1
Checksum:i451B868679E5B9B0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8E0G5E8E0_MOUSE
Regulator of G-protein signaling 17...
Rgs17 mCG_14635
230Annotation score:
F8WH97F8WH97_MOUSE
Regulator of G-protein-signaling 17
Rgs17
163Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191555 mRNA Translation: AAF05758.1
AK018279 mRNA Translation: BAB31145.1
AK030492 mRNA Translation: BAC26989.1
AK046009 mRNA Translation: BAC32571.1
AK163188 mRNA Translation: BAE37226.1
CCDSiCCDS56685.1
RefSeqiNP_001155294.1, NM_001161822.1
NP_064342.1, NM_019958.4
XP_006512520.1, XM_006512457.3
UniGeneiMm.44606

Genome annotation databases

EnsembliENSMUST00000117676; ENSMUSP00000113519; ENSMUSG00000019775
ENSMUST00000131996; ENSMUSP00000116291; ENSMUSG00000019775
GeneIDi56533
KEGGimmu:56533
UCSCiuc007egg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191555 mRNA Translation: AAF05758.1
AK018279 mRNA Translation: BAB31145.1
AK030492 mRNA Translation: BAC26989.1
AK046009 mRNA Translation: BAC32571.1
AK163188 mRNA Translation: BAE37226.1
CCDSiCCDS56685.1
RefSeqiNP_001155294.1, NM_001161822.1
NP_064342.1, NM_019958.4
XP_006512520.1, XM_006512457.3
UniGeneiMm.44606

3D structure databases

ProteinModelPortaliQ9QZB0
SMRiQ9QZB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065825

PTM databases

iPTMnetiQ9QZB0
PhosphoSitePlusiQ9QZB0

Proteomic databases

MaxQBiQ9QZB0
PaxDbiQ9QZB0
PRIDEiQ9QZB0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117676; ENSMUSP00000113519; ENSMUSG00000019775
ENSMUST00000131996; ENSMUSP00000116291; ENSMUSG00000019775
GeneIDi56533
KEGGimmu:56533
UCSCiuc007egg.2 mouse

Organism-specific databases

CTDi26575
MGIiMGI:1927469 Rgs17

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiQ9QZB0
KOiK16449
OMAiCQNPTSD
PhylomeDBiQ9QZB0
TreeFamiTF315837

Miscellaneous databases

PROiPR:Q9QZB0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019775 Expressed in 171 organ(s), highest expression level in secondary oocyte
CleanExiMM_RGS17
ExpressionAtlasiQ9QZB0 baseline and differential
GenevisibleiQ9QZB0 MM

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS17_MOUSE
AccessioniPrimary (citable) accession number: Q9QZB0
Secondary accession number(s): Q543T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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