UniProtKB - Q9QZA1 (PHLA1_RAT)
Protein
Pleckstrin homology-like domain family A member 1
Gene
Phlda1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.1 Publication
GO - Molecular functioni
- phosphatidylinositol phosphate binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- FasL biosynthetic process Source: RGD
- forebrain neuron differentiation Source: RGD
- positive regulation of apoptotic process Source: RGD
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-RNO-8854521, Interaction between PHLDA1 and AURKA |
Names & Taxonomyi
Protein namesi | Recommended name: Pleckstrin homology-like domain family A member 1Alternative name(s): Proline- and glutamine-rich protein Short name: PQ-rich protein Short name: PQR protein |
Gene namesi | Name:Phlda1 Synonyms:Pqr |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3836, Phlda1 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Other locations
- Cytoplasm By similarity
- Cytoplasmic vesicle By similarity
Note: Colocalizes with intracellular vesicles.By similarity
Nucleus
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053899 | 1 – 407 | Pleckstrin homology-like domain family A member 1Add BLAST | 407 |
Proteomic databases
PaxDbi | Q9QZA1 |
PRIDEi | Q9QZA1 |
Expressioni
Developmental stagei
Expression increases during embryonal development at embryonic days E11, E15 and E17.1 Publication
Inductioni
Induced by FGF in a hippocampal progenitor cell line. Induced by FGF and EGF in a CNS neuronal cell line.1 Publication
Interactioni
Subunit structurei
Interacts with RPL14, EIF3S7 and PABPC4.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005361 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 184 | PHAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 312 – 348 | 15 X 2 AA repeats of P-QAdd BLAST | 37 | |
Regioni | 354 – 381 | 11 X 2 AA repeats of P-HAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 193 – 201 | Poly-Gln | 9 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502RZ5Q, Eukaryota |
InParanoidi | Q9QZA1 |
PhylomeDBi | Q9QZA1 |
Family and domain databases
InterProi | View protein in InterPro IPR001849, PH_domain IPR042832, PHLA1/2/3 |
PANTHERi | PTHR15478, PTHR15478, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9QZA1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRTPAAERL SELGFPPRRG SQEPPFPLGV TRGWGGWPIE KRCEGPRPVP
60 70 80 90 100
FSERSAEDGR EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL
110 120 130 140 150
CALRAGGRGS RWSEDSARLL LLPPAGASGS LKAERSSSTP YAGRMLESSG
160 170 180 190 200
CKALKEGVLE KRSDGLLQLW KKKCCILTEE GLLLIPPKQV QHQQQQQQQQ
210 220 230 240 250
QPGQGTAEPS QPSGPAVTSL EPPAKLKELH FSNMKTVDCV ERKGKYMYFT
260 270 280 290 300
VVMAEGKEID FRCPQDQGWN AEITLQMVQY KNRQAILAVK STRQKQQHLV
310 320 330 340 350
QQQPPQTQQI QPQPQQPQIQ PQPQPQIQPQ PQPQPQPQPQ PQQQPQPQQL
360 370 380 390 400
HSYPHPHPHL YPHPHPHAHS HPHPHPHPHP HQLQHAHQPL HSQPQGHRLL
RSTSNSA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1LNT5 | F1LNT5_RAT | Pleckstrin homology-like domain fam... | Phlda1 rCG_49047 | 406 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03055997 Genomic DNA No translation available. AF192802 mRNA Translation: AAF07181.1 |
Genome annotation databases
UCSCi | RGD:3836, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03055997 Genomic DNA No translation available. AF192802 mRNA Translation: AAF07181.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005361 |
Proteomic databases
PaxDbi | Q9QZA1 |
PRIDEi | Q9QZA1 |
Genome annotation databases
UCSCi | RGD:3836, rat |
Organism-specific databases
RGDi | 3836, Phlda1 |
Phylogenomic databases
eggNOGi | ENOG502RZ5Q, Eukaryota |
InParanoidi | Q9QZA1 |
PhylomeDBi | Q9QZA1 |
Enzyme and pathway databases
Reactomei | R-RNO-8854521, Interaction between PHLDA1 and AURKA |
Miscellaneous databases
PROi | PR:Q9QZA1 |
Family and domain databases
InterProi | View protein in InterPro IPR001849, PH_domain IPR042832, PHLA1/2/3 |
PANTHERi | PTHR15478, PTHR15478, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHLA1_RAT | |
Accessioni | Q9QZA1Primary (citable) accession number: Q9QZA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 5, 2009 | |
Last modified: | August 12, 2020 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |