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Protein

Carbonic anhydrase 5B, mitochondrial

Gene

Ca5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi132Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi155Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • carbonate dehydratase activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • response to bacterium Source: MGI

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 5B, mitochondrial (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VB
Carbonic anhydrase VB
Short name:
CA-VB
Gene namesi
Name:Ca5b
Synonyms:Car5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1926249 Car5b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionBy similarityAdd BLAST33
ChainiPRO_000000423834 – 317Carbonic anhydrase 5B, mitochondrialAdd BLAST284

Proteomic databases

EPDiQ9QZA0
MaxQBiQ9QZA0
PaxDbiQ9QZA0
PeptideAtlasiQ9QZA0
PRIDEiQ9QZA0

PTM databases

PhosphoSitePlusiQ9QZA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000031373 Expressed in 108 organ(s), highest expression level in white adipose tissue
CleanExiMM_CAR5B
GenevisibleiQ9QZA0 MM

Structurei

3D structure databases

ProteinModelPortaliQ9QZA0
SMRiQ9QZA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 296Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 236Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiQ9QZA0
KOiK01672
OMAiIKHKDTL
OrthoDBiEOG091G0XFM
PhylomeDBiQ9QZA0
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR018437 CA-VB_mt
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF25 PTHR18952:SF25, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QZA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMNHLRVI LQVSSSTLPW RRCWVPRLVP RRSCSLYTCT YRTRNRALPP
60 70 80 90 100
LWENLDLVPA GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHIWNNGY
110 120 130 140 150
SFLVEFEDST DKSVVEGGPL EHNYRLKQFH FHWGAIDAWG SEHTVDSKCY
160 170 180 190 200
PAELHLVHWN AVKFESFEDA ALEENGLAVI GVFLKLGKHH KELQKLVDTL
210 220 230 240 250
PSIKHKDTLV EFGSFDPSCL MPTCPDYWTY SGSLTTPPLS ESVTWIIKKQ
260 270 280 290 300
PVEVDRDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY
310
VLNIQVKPKP TASEVTP
Length:317
Mass (Da):36,623
Last modified:May 9, 2003 - v2
Checksum:i719016A75305BFD3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269S → F in BAC39501 (PubMed:16141072).Curated1
Sequence conflicti308P → A in AAF08291 (PubMed:10677517).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192978 mRNA Translation: AAF08291.1
AK085670 mRNA Translation: BAC39501.1
BC034413 mRNA Translation: AAH34413.1
CCDSiCCDS30515.1
RefSeqiNP_851832.2, NM_181315.4
UniGeneiMm.180953

Genome annotation databases

EnsembliENSMUST00000033739; ENSMUSP00000033739; ENSMUSG00000031373
GeneIDi56078
KEGGimmu:56078
UCSCiuc009uvb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCAH5B_MOUSE
AccessioniPrimary (citable) accession number: Q9QZA0
Secondary accession number(s): Q8C3J9, Q8K014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 9, 2003
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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