Myoglobin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• heme binding Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Role of myoglobin as a scavenger of cellular NO in myocardium."
    Kreutzer U., Jue T.
    Am. J. Physiol. Heart Circ. Physiol. 286:H985-91(2004) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• oxygen binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Virtual cooperativity in myoglobin oxygen saturation curve in skeletal muscle in vivo."
    Seiyama A.
    Dyn Med 5:3-3(2006) [PubMed] [Europe PMC] [Abstract]
• oxygen carrier activity Source: UniProtKB-KW

GO - Biological processⁱ

• brown fat cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Wdnm1-like, a new adipokine with a role in MMP-2 activation."
    Wu Y., Smas C.M.
    Am. J. Physiol. 295:E205-215(2008) [PubMed] [Europe PMC] [Abstract]
• enucleate erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Adaptation of the myoglobin knockout mouse to hypoxic stress."
    Schlieper G., Kim J.H., Molojavyi A., Jacoby C., Laussmann T., Flogel U., Godecke A., Schrader J.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 286:R786-92(2004) [PubMed] [Europe PMC] [Abstract]
• heart development Source: RGDInferred from sequence orthologyⁱ
  • "Adaptive mechanisms that preserve cardiac function in mice without myoglobin."
    Meeson A.P., Radford N., Shelton J.M., Mammen P.P., DiMaio J.M., Hutcheson K., Kong Y., Elterman J., Williams R.S., Garry D.J.
    Circ. Res. 88:713-720(2001) [PubMed] [Europe PMC] [Abstract]
• oxygen transport Source: RGDInferred from direct assayⁱ
  • "Myoglobin translational diffusion in rat myocardium and its implication on intracellular oxygen transport."
    Lin P.C., Kreutzer U., Jue T.
    J. Physiol. (Lond.) 578:595-603(2007) [PubMed] [Europe PMC] [Abstract]
• response to hormone Source: RGDInferred from direct assayⁱ
  • "Thyroid hormone stimulates myoglobin gene expression in rat cardiac muscle."
    Giannocco G., DosSantos R.A., Nunes M.T.
    Mol. Cell. Endocrinol. 226:19-26(2004) [PubMed] [Europe PMC] [Abstract]
• response to hydrogen peroxide Source: RGDInferred from direct assayⁱ
  • "Immunological identification of the heart myoglobin radical formed by hydrogen peroxide."
    Detweiler C.D., Deterding L.J., Tomer K.B., Chignell C.F., Germolec D., Mason R.P.
    Free Radic. Biol. Med. 33:364-369(2002) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from sequence orthologyⁱ
  • "Adaptation of the myoglobin knockout mouse to hypoxic stress."
    Schlieper G., Kim J.H., Molojavyi A., Jacoby C., Laussmann T., Flogel U., Godecke A., Schrader J.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 286:R786-92(2004) [PubMed] [Europe PMC] [Abstract]
• slow-twitch skeletal muscle fiber contraction Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Proteomic analysis of slow- and fast-twitch skeletal muscles."
    Okumura N., Hashida-Okumura A., Kita K., Matsubae M., Matsubara T., Takao T., Nagai K.
    Proteomics 5:2896-2906(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGLSDGEWQM VLNIWGKVEG DLAGHGQEVL ISLFKAHPET LEKFDKFKNL 
        60         70         80         90        100
KSEEEMKSSE DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI 
       110        120        130        140        150
PVKYLEFISE VIIQVLKKRY SGDFGADAQG AMSKALELFR NDIAAKYKEL 

GFQG                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families