Dmrt1

Functionⁱ

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis.7 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	70 – 116	DMPROSITE-ProRule annotationAdd BLAST		47

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 23473982
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 17605809
identical protein binding Source: MGI
metal ion binding Source: UniProtKB-KW
protein heterodimerization activity
Source: MGI
Inferred from physical interactionⁱ
- 17605809
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 17605809
proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20616082
- 20951351
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 17605809
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 17605809

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17540358
developmental process involved in reproduction
Source: MGI
Inferred from genetic interactionⁱ
- 17540358
germ cell migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 17540358
intracellular signal transduction Source: MGI
male germ cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20007774
- 20951351
male gonad development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17540358
male sex determination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
male sex differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
negative regulation of meiotic nuclear division
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20951351
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
oocyte development
Source: MGI
Inferred from mutant phenotypeⁱ
- 21621532
positive regulation of male gonad development
Source: MGI
Inferred from mutant phenotypeⁱ
- 21775990
positive regulation of meiosis I
Source: MGI
Inferred from mutant phenotypeⁱ
- 21621532
positive regulation of mitotic nuclear division
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20951351
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 20616082
- 20951351
regulation of nodal signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 23473982
Sertoli cell development
Source: MGI
Inferred from mutant phenotypeⁱ
- 21775990
Sertoli cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11040213
spermatogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17540358

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Differentiation, Sexual differentiation, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Doublesex- and mab-3-related transcription factor 1
Gene namesⁱ	Name:Dmrt1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1354733 Dmrt1

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Severe defects in the adult testis with hypoplastic testes and disorganization of seminiferous tubules and absence of germ cells, due to pre-meiotic germ cell death in testes. Sertoli cell fail to differentiate. Female mutant mice have normal ovaries and are fertile. Depending on the strain background mice also show testis teratomas: deletion in 129/Sv strain causes a high incidence of teratomas, whereas these tumors do not form in C57BL/6J mutant mice. Deletion of Dmrt1 during fetal development causes postnatal Sertoli cells to lose male-promoting Sox9 and instead activation of female-promoting genes such as Foxl2, leading to reprogrammation of Sertoli cells into granulosa cells. As a consequence, theca cells form, estrogen is produced and germ cells appear feminized.3 Publications

Keywords - Diseaseⁱ

Tumor suppressor

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000207043	1 – 374	Doublesex- and mab-3-related transcription factor 1Add BLAST		374

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	337	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9QZ59
PRIDEⁱ	Q9QZ59

PTM databases

iPTMnetⁱ	Q9QZ59
PhosphoSitePlusⁱ	Q9QZ59

Expressionⁱ

Tissue specificityⁱ

Testis-specific. In adult testis, expressed in Sertoli cells in all regions of the seminiferous tubules. Expressed dynamically in premeiotic germ cells (spermatogonia), with high expression only in regions of the seminiferous tubule that are early in the spermatogenic cycle (at protein level). Expressed in all mitotic spermatogonia. Expression decreases with the onset of spermatogonial differentiation and disappears at the initiation of meiosis.2 Publications

Developmental stageⁱ

Detected already at 9.5 dpc. At 10.5 dpc, expressed in the genital ridges of both sexes. At 14.5 dpc, during gonadal sexual differentiation, expression declines in the ovary, but is maintained in the testis, where it becomes restricted to Sertoli and germ cells in the developing seminiferous tubules of the testis. Accumulates primarily in Sertoli cells. From P1, appears in germ cells and reach high levels by P7, just before meiosis begins. From P7 through adult stage, present in Sertoli cells and undifferentiated germ cells, but not in differentiating germ cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000024837 Expressed in 51 organ(s), highest expression level in testis
Genevisibleⁱ	Q9QZ59 MM

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding Source: MGI
protein heterodimerization activity
Source: MGI
Inferred from physical interactionⁱ
- 17605809
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 17605809

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q9QZ59, 1 interactor
STRINGⁱ	10090.ENSMUSP00000025755

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QZ59
SMRⁱ	Q9QZ59
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	323 – 346	Pro/Ser-richAdd BLAST		24

Sequence similaritiesⁱ

Belongs to the DMRT family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3815 Eukaryota ENOG410XSK9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074486
HOGENOMⁱ	HOG000059585
HOVERGENⁱ	HBG055845
InParanoidⁱ	Q9QZ59
KEGG Orthology (KO) More...KOⁱ	K19488
OMAⁱ	NRHAMSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PWB
TreeFamⁱ	TF317837

Family and domain databases

Gene3Dⁱ	4.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR001275 DM_DNA-bd IPR036407 DM_DNA-bd_sf IPR026607 DMRT/dsx/mab-3 IPR022114 DMRT1-like
PANTHERⁱ	PTHR12322 PTHR12322, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00751 DM, 1 hit PF12374 Dmrt1, 1 hit
SMARTⁱ	View protein in SMART SM00301 DM, 1 hit
SUPFAMⁱ	SSF82927 SSF82927, 1 hit
PROSITEⁱ	View protein in PROSITE PS40000 DM_1, 1 hit PS50809 DM_2, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9QZ59-1) [UniParc]FASTA Add to basket

Also known as: Dmrt1a, Dmrt1a1, Dmrt1a2, Dmrt1a3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNDDTFGKP STPTEVPHAP GAPPQGKAGG YSKAAGAMAG AAGGSGAGGS 
        60         70         80         90        100
GGASGSGPSG LGSGSKKSPR LPKCARCRNH GYASPLKGHK RFCMWRDCQC 
       110        120        130        140        150
KKCSLIAERQ RVMAAQVALR RQQAQEEELG ISHPIPLPSA AELLVKRENN 
       160        170        180        190        200
ASNPCLMAEN SSSAQPPPAS TPTPAASEGR MVIQDIPAVT SRGHMENTSD 
       210        220        230        240        250
LVSDPAYYSS FYQPSLFPYY NNLYNYPQYS MALSAESSSG EVGNSLGGSP 
       260        270        280        290        300
VKNSLRSLPA PYVPAQTGNQ WQMKTSESRH PVSSQYRMHS YYGPPSYLGQ 
       310        320        330        340        350
SMSQIFTFEE GPSYSEAKAS VFSPPSSQDS GLVSLSSSSP MSNESSKGVL 
       360        370 
ECESASSEPS SYAVNQVLEE DEDE

Length:374

Mass (Da):39,444

Last modified:April 18, 2012 - v2

Checksum:ⁱB6C4601432007C35

GO

Isoform 2 (identifier: Q9QZ59-2) [UniParc]FASTA Add to basket

Also known as: Dmrt1b, DMR1g, Dmrt1g

The sequence of this isoform differs from the canonical sequence as follows:
213-374: Missing.

« Hide

        10         20         30         40         50
MPNDDTFGKP STPTEVPHAP GAPPQGKAGG YSKAAGAMAG AAGGSGAGGS 
        60         70         80         90        100
GGASGSGPSG LGSGSKKSPR LPKCARCRNH GYASPLKGHK RFCMWRDCQC 
       110        120        130        140        150
KKCSLIAERQ RVMAAQVALR RQQAQEEELG ISHPIPLPSA AELLVKRENN 
       160        170        180        190        200
ASNPCLMAEN SSSAQPPPAS TPTPAASEGR MVIQDIPAVT SRGHMENTSD 
       210 
LVSDPAYYSS FY

Show »

Length:212

Mass (Da):21,891

Checksum:ⁱ995A1A053EFC8840

GO

Isoform 3 (identifier: Q9QZ59-3) [UniParc]FASTA Add to basket

Also known as: Dmrt1d

The sequence of this isoform differs from the canonical sequence as follows:
1-180: Missing.

« Hide

        10         20         30         40         50
MVIQDIPAVT SRGHMENTSD LVSDPAYYSS FYQPSLFPYY NNLYNYPQYS 
        60         70         80         90        100
MALSAESSSG EVGNSLGGSP VKNSLRSLPA PYVPAQTGNQ WQMKTSESRH 
       110        120        130        140        150
PVSSQYRMHS YYGPPSYLGQ SMSQIFTFEE GPSYSEAKAS VFSPPSSQDS 
       160        170        180        190 
GLVSLSSSSP MSNESSKGVL ECESASSEPS SYAVNQVLEE DEDE

Show »

Length:194

Mass (Da):21,148

Checksum:ⁱ69A02CDAABC2DE47

GO

Isoform 4 (identifier: Q9QZ59-4) [UniParc]FASTA Add to basket

Also known as: Dmrt1c

The sequence of this isoform differs from the canonical sequence as follows:
178-374: EGRMVIQDIP...NQVLEEDEDE → DEDLREPPPS...QRELEGSSGM

« Hide

        10         20         30         40         50
MPNDDTFGKP STPTEVPHAP GAPPQGKAGG YSKAAGAMAG AAGGSGAGGS 
        60         70         80         90        100
GGASGSGPSG LGSGSKKSPR LPKCARCRNH GYASPLKGHK RFCMWRDCQC 
       110        120        130        140        150
KKCSLIAERQ RVMAAQVALR RQQAQEEELG ISHPIPLPSA AELLVKRENN 
       160        170        180        190        200
ASNPCLMAEN SSSAQPPPAS TPTPAASDED LREPPPSELP VPDALILRAS 
       210        220        230        240        250
LLPGPEHVPD LYLRGRPLLL RSQSQCVLAP QQSRFWLGLP LQQLSDEQRE 

LEGSSGM

Show »

Length:257

Mass (Da):26,906

Checksum:ⁱED63F763E109DB2B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	Q → K in AAF12826 (PubMed:10545231).Curated	1
Sequence conflictⁱ	306	F → L in CAB62040 (PubMed:10640721).Curated	1
Sequence conflictⁱ	365	N → S in CAB62040 (PubMed:10640721).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_042963	1 – 180	Missing in isoform 3. 1 PublicationAdd BLAST	180
Alternative sequenceⁱVSP_042964	178 – 374	EGRMV…EDEDE → DEDLREPPPSELPVPDALIL RASLLPGPEHVPDLYLRGRP LLLRSQSQCVLAPQQSRFWL GLPLQQLSDEQRELEGSSGM in isoform 4. 1 PublicationAdd BLAST	197
Alternative sequenceⁱVSP_042965	213 – 374	Missing in isoform 2. 1 PublicationAdd BLAST	162

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF202778 mRNA Translation: AAF12826.1 AL133300 mRNA Translation: CAB62040.1 AY169785 mRNA Translation: AAO41733.1 AY169786 mRNA Translation: AAO41734.1 AY169787 mRNA Translation: AAO41735.1 AY943925 mRNA Translation: AAY20941.1 DQ530630 mRNA Translation: ABF83854.1 AC132140 Genomic DNA No translation available. CH466534 Genomic DNA Translation: EDL41631.1 BC125474 mRNA Translation: AAI25475.1 AF192561 mRNA Translation: AAF05764.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29717.1 [Q9QZ59-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_056641.2, NM_015826.5 [Q9QZ59-1]
UniGeneⁱ	Mm.391208

Genome annotation databases

Ensemblⁱ	ENSMUST00000025755; ENSMUSP00000025755; ENSMUSG00000024837 [Q9QZ59-1] ENSMUST00000087525; ENSMUSP00000084803; ENSMUSG00000024837 [Q9QZ59-4]
GeneIDⁱ	50796
KEGGⁱ	mmu:50796
UCSC genome browser More...UCSCⁱ	uc008hbi.1 mouse [Q9QZ59-1] uc012bjv.1 mouse [Q9QZ59-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9QZ59	Isoform 2 of Doublesex- and mab-3-related transcription factor 1		MOUSE		212	UniRef100_Q9QZ59
Isoform 3 of Doublesex- and mab-3-related transcription factor 1		MOUSE		194
Doublesex and mab-3 related transcription factor 1b		MOUSE		167

Protein	Similar proteins		Species	Score	Length	Source
Q9QZ59	Isoform 2 of Doublesex- and mab-3-related transcription factor 1		MOUSE		212	UniRef90_Q9QZ59
Doublesex and mab-3 related transcription factor 1		RAT		374
doublesex- and mab-3-related transcription factor 1		MESAU		374
UPI000B4F3FD8		MERUN		376
UPI000A309B80		MUSPA		375
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9QZ59	Doublesex- and mab-3-related transcription factor 1		PIG		373	UniRef50_Q9QZ59
Doublesex- and mab-3-related transcription factor 1		XENTR		337
Doublesex- and mab-3-related transcription factor 1A		XENLA		336
Isoform 2 of Doublesex- and mab-3-related transcription factor 1		MOUSE		212
Doublesex and mab-3 related transcription factor 1		RAT		374
+118
Q9QZ59-4	Doublesex and mab-3 related transcription factor 1		SAIBB		310	UniRef50_Q9QZ59-4
Doublesex and mab-3 related transcription factor 1		SARHA		262
Doublesex and mab-3 related transcription factor 1		SARHA		248
UPI000533C3BC		SAIBB		313

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF202778 mRNA Translation: AAF12826.1 AL133300 mRNA Translation: CAB62040.1 AY169785 mRNA Translation: AAO41733.1 AY169786 mRNA Translation: AAO41734.1 AY169787 mRNA Translation: AAO41735.1 AY943925 mRNA Translation: AAY20941.1 DQ530630 mRNA Translation: ABF83854.1 AC132140 Genomic DNA No translation available. CH466534 Genomic DNA Translation: EDL41631.1 BC125474 mRNA Translation: AAI25475.1 AF192561 mRNA Translation: AAF05764.1
CCDSⁱ	CCDS29717.1 [Q9QZ59-1]
RefSeqⁱ	NP_056641.2, NM_015826.5 [Q9QZ59-1]
UniGeneⁱ	Mm.391208

3D structure databases

ProteinModelPortalⁱ	Q9QZ59
SMRⁱ	Q9QZ59
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9QZ59, 1 interactor
STRINGⁱ	10090.ENSMUSP00000025755

PTM databases

iPTMnetⁱ	Q9QZ59
PhosphoSitePlusⁱ	Q9QZ59

Proteomic databases

PaxDbⁱ	Q9QZ59
PRIDEⁱ	Q9QZ59

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025755; ENSMUSP00000025755; ENSMUSG00000024837 [Q9QZ59-1] ENSMUST00000087525; ENSMUSP00000084803; ENSMUSG00000024837 [Q9QZ59-4]
GeneIDⁱ	50796
KEGGⁱ	mmu:50796
UCSCⁱ	uc008hbi.1 mouse [Q9QZ59-1] uc012bjv.1 mouse [Q9QZ59-4]

Organism-specific databases

CTDⁱ	1761
MGIⁱ	MGI:1354733 Dmrt1

Phylogenomic databases

eggNOGⁱ	KOG3815 Eukaryota ENOG410XSK9 LUCA
GeneTreeⁱ	ENSGT00550000074486
HOGENOMⁱ	HOG000059585
HOVERGENⁱ	HBG055845
InParanoidⁱ	Q9QZ59
KOⁱ	K19488
OMAⁱ	NRHAMSS
OrthoDBⁱ	EOG091G0PWB
TreeFamⁱ	TF317837

Miscellaneous databases

ChiTaRSⁱ	Dmrt1 mouse
Protein Ontology More...PROⁱ	PR:Q9QZ59
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024837 Expressed in 51 organ(s), highest expression level in testis
Genevisibleⁱ	Q9QZ59 MM

Family and domain databases

Gene3Dⁱ	4.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR001275 DM_DNA-bd IPR036407 DM_DNA-bd_sf IPR026607 DMRT/dsx/mab-3 IPR022114 DMRT1-like
PANTHERⁱ	PTHR12322 PTHR12322, 2 hits
Pfamⁱ	View protein in Pfam PF00751 DM, 1 hit PF12374 Dmrt1, 1 hit
SMARTⁱ	View protein in SMART SM00301 DM, 1 hit
SUPFAMⁱ	SSF82927 SSF82927, 1 hit
PROSITEⁱ	View protein in PROSITE PS40000 DM_1, 1 hit PS50809 DM_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DMRT1_MOUSE
Accessionⁱ	Q9QZ59Primary (citable) accession number: Q9QZ59 Secondary accession number(s): Q19AV2 , Q2TDQ9, Q6Y951, Q6Y953, Q9QZ37, Q9QZA4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	April 18, 2012
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniProtKB - Q9QZ59 (DMRT1_MOUSE)

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Doublesex- and mab-3-related transcription factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ