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Protein

Heat shock protein beta-3

Gene

Hspb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibitor of actin polymerization.By similarity

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-3
Short name:
HspB3
Gene namesi
Name:Hspb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1928479 Hspb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259371 – 154Heat shock protein beta-3Add BLAST154

Proteomic databases

PaxDbiQ9QZ57
PRIDEiQ9QZ57

PTM databases

PhosphoSitePlusiQ9QZ57

Expressioni

Gene expression databases

BgeeiENSMUSG00000051456 Expressed in 107 organ(s), highest expression level in quadriceps femoris
CleanExiMM_HSPB3
GenevisibleiQ9QZ57 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054193

Structurei

3D structure databases

ProteinModelPortaliQ9QZ57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 154sHSPPROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000286024
HOVERGENiHBG052039
InParanoidiQ9QZ57
KOiK09544
OMAiFCHDGIL
OrthoDBiEOG091G0USC
PhylomeDBiQ9QZ57
TreeFamiTF105049

Family and domain databases

CDDicd06477 ACD_HspB3_Like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR033894 HSPB3
PANTHERiPTHR11527 PTHR11527, 1 hit
PTHR11527:SF29 PTHR11527:SF29, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZ57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKIILRHLI ETPVRYQEEF EARGLEDCRL DHTLYALPGP TIEDLSKARG
60 70 80 90 100
AGTPQALAED SASTEKPPGE GKSRFQILLD VVQFLPEDII IQTFEGWLLI
110 120 130 140 150
KAQHGTRMDE HGFISRSFTR QYKLPDGVET KDLSAILCHD GILVVEVKDS

LGTK
Length:154
Mass (Da):17,230
Last modified:May 1, 2000 - v1
Checksum:iECBAAD45221FE2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203375 mRNA Translation: AAF09589.1
AK009633 mRNA Translation: BAB26404.1
BC065388 mRNA Translation: AAH65388.1
BC092376 mRNA Translation: AAH92376.1
CCDSiCCDS26785.1
RefSeqiNP_064344.1, NM_019960.2
UniGeneiMm.41410

Genome annotation databases

EnsembliENSMUST00000054650; ENSMUSP00000054193; ENSMUSG00000051456
GeneIDi56534
KEGGimmu:56534
UCSCiuc007rxi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203375 mRNA Translation: AAF09589.1
AK009633 mRNA Translation: BAB26404.1
BC065388 mRNA Translation: AAH65388.1
BC092376 mRNA Translation: AAH92376.1
CCDSiCCDS26785.1
RefSeqiNP_064344.1, NM_019960.2
UniGeneiMm.41410

3D structure databases

ProteinModelPortaliQ9QZ57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054193

PTM databases

PhosphoSitePlusiQ9QZ57

Proteomic databases

PaxDbiQ9QZ57
PRIDEiQ9QZ57

Protocols and materials databases

DNASUi56534
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054650; ENSMUSP00000054193; ENSMUSG00000051456
GeneIDi56534
KEGGimmu:56534
UCSCiuc007rxi.2 mouse

Organism-specific databases

CTDi8988
MGIiMGI:1928479 Hspb3

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000286024
HOVERGENiHBG052039
InParanoidiQ9QZ57
KOiK09544
OMAiFCHDGIL
OrthoDBiEOG091G0USC
PhylomeDBiQ9QZ57
TreeFamiTF105049

Miscellaneous databases

PROiPR:Q9QZ57
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051456 Expressed in 107 organ(s), highest expression level in quadriceps femoris
CleanExiMM_HSPB3
GenevisibleiQ9QZ57 MM

Family and domain databases

CDDicd06477 ACD_HspB3_Like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR033894 HSPB3
PANTHERiPTHR11527 PTHR11527, 1 hit
PTHR11527:SF29 PTHR11527:SF29, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB3_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ57
Secondary accession number(s): Q569N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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