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Entry version 134 (12 Aug 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Troponin T, fast skeletal muscle

Gene

Tnnt3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-390522, Striated Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Troponin T, fast skeletal muscle
Short name:
TnTf
Alternative name(s):
Fast skeletal muscle troponin T
Short name:
fTnT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tnnt3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109550, Tnnt3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861792 – 272Troponin T, fast skeletal muscleAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei91PhosphoserineBy similarity1
Modified residuei162PhosphoserineCombined sources1
Modified residuei169PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei222PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9QZ47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QZ47

PRoteomics IDEntifications database

More...
PRIDEi
Q9QZ47

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QZ47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QZ47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in skeletal muscle.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Embryo and neonate express predominantly acidic isoforms while all adult isoforms are basic. Only one isoform, B2e17, is found in both embryo/neonate and adult. A transition from high to low molecular weight isoforms is also seen during postnatal development.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
204269, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9QZ47, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9QZ47

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000136278

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9QZ47, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QZ47

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3634, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QZ47

KEGG Orthology (KO)

More...
KOi
K12046

Database of Orthologous Groups

More...
OrthoDBi
1480247at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QZ47

TreeFam database of animal gene trees

More...
TreeFami
TF313321

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027707, TNNT
IPR027708, Tnnt3
IPR001978, Troponin
IPR038077, Troponin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11521, PTHR11521, 1 hit
PTHR11521:SF4, PTHR11521:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00992, Troponin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90250, SSF90250, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (14+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 14 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Isoforms A1e17, A2e17, A3e17, A4e17, A5e17 and A6e17 are acidic while isoforms B1e16, B2e17, B2e16, B3e17, B3e16, B4e17 and B4e16 are basic.

This entry has 14 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1e17 (identifier: Q9QZ47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDEETEQVE EQYEEEEEAQ EEEVQEEAPE PEEVQEDAVA EEEREEDEEE
60 70 80 90 100
EKPRPKLTAP KIPEGEKVDF DDIQKKRQNK DLMELQALID SHFEARKKEE
110 120 130 140 150
EELIALKERI EKRRAERAEQ QRIRAEKERE PQNRLAEEKA RREEEDAKRR
160 170 180 190 200
AEDDMKKKKA LSSMGANYSS YLAKADQKRG KKQTAREMKK KILAERRKPL
210 220 230 240 250
NIDHLSDDKL RDKAKELWDT LYQLETDKFE FGEKLKRQKY DITTLRSRID
260 270
QAQKHSKKAG ATAKGKVGGR WK
Length:272
Mass (Da):32,241
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AF24573DD6A9529
GO
Isoform A2e17 (identifier: Q9QZ47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-31: Missing.

Show »
Length:268
Mass (Da):31,846
Checksum:i63FB09D0C89EEC2E
GO
Isoform A3e17 (identifier: Q9QZ47-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-31: Missing.

Show »
Length:263
Mass (Da):31,232
Checksum:i364102F00A761039
GO
Isoform A4e17 (identifier: Q9QZ47-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-16: Missing.
     28-31: Missing.

Show »
Length:262
Mass (Da):31,039
Checksum:i6A42D00696FDAA06
GO
Isoform A5e17 (identifier: Q9QZ47-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-49: Missing.

Show »
Length:259
Mass (Da):30,709
Checksum:i115DCF3122134E48
GO
Isoform A6e17 (identifier: Q9QZ47-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-31: Missing.
     37-49: Missing.

Show »
Length:255
Mass (Da):30,315
Checksum:i59E4EEC2E6A444D9
GO
Isoform B1e16 (identifier: Q9QZ47-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-49: Missing.
     243-255: TTLRSRIDQAQKH → MTVRARVEMLAKF

Show »
Length:254
Mass (Da):30,093
Checksum:i888FDC086E2BA29B
GO
Isoform B2e17 (identifier: Q9QZ47-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-31: Missing.
     37-49: Missing.

Show »
Length:250
Mass (Da):29,700
Checksum:iE4EDD331B6B81FE2
GO
Isoform B2e16 (identifier: Q9QZ47-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-31: Missing.
     37-49: Missing.
     243-255: TTLRSRIDQAQKH → MTVRARVEMLAKF

Show »
Length:250
Mass (Da):29,699
Checksum:iF41BF2A5A863BEE6
GO
Isoform B3e17 (identifier: Q9QZ47-10) [UniParc]FASTAAdd to basket
Also known as: PTROPT

The sequence of this isoform differs from the canonical sequence as follows:
     11-16: Missing.
     32-49: Missing.

Show »
Length:248
Mass (Da):29,287
Checksum:i8D1A78E81588F80D
GO
Isoform B3e16 (identifier: Q9QZ47-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-16: Missing.
     32-49: Missing.
     243-255: TTLRSRIDQAQKH → MTVRARVEMLAKF

Show »
Length:248
Mass (Da):29,285
Checksum:i9DEC597C0B535909
GO
Isoform B4e17 (identifier: Q9QZ47-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-16: Missing.
     23-49: Missing.

Show »
Length:239
Mass (Da):28,278
Checksum:iB20A4C0EA50A55AD
GO
Isoform B4e16 (identifier: Q9QZ47-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-16: Missing.
     23-49: Missing.
     243-255: TTLRSRIDQAQKH → MTVRARVEMLAKF

Show »
Length:239
Mass (Da):28,276
Checksum:iA2FC6D9ABBD1F4A9
GO
Isoform 14 (identifier: Q9QZ47-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-255: TTLRSRIDQAQKH → MTVRARVEMLAKF

Show »
Length:272
Mass (Da):32,239
Checksum:i4A0464E7C3B1342D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YNB2Z4YNB2_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
272Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6I3A2A6I3_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
248Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6I8A2A6I8_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
239Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6I0A2A6I0_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
250Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6J0A2A6J0_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6I5A2A6I5_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
239Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6J1A2A6J1_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
250Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YJU0Z4YJU0_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
268Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YKG3Z4YKG3_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
262Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YKG8Z4YKG8_MOUSE
Troponin T, fast skeletal muscle
Tnnt3
263Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252A → T in AAB39743 (PubMed:9107680).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti131P → R1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05033811 – 16Missing in isoform A4e17, isoform B3e17, isoform B3e16, isoform B4e17 and isoform B4e16. 1 Publication6
Alternative sequenceiVSP_05034023 – 49Missing in isoform B4e17 and isoform B4e16. CuratedAdd BLAST27
Alternative sequenceiVSP_05033923 – 31Missing in isoform A3e17, isoform B2e17 and isoform B2e16. Curated9
Alternative sequenceiVSP_05034128 – 31Missing in isoform A2e17, isoform A4e17 and isoform A6e17. Curated4
Alternative sequenceiVSP_05034232 – 49Missing in isoform B1e16, isoform B3e17 and isoform B3e16. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05034337 – 49Missing in isoform A5e17, isoform A6e17, isoform B2e17 and isoform B2e16. CuratedAdd BLAST13
Alternative sequenceiVSP_050344243 – 255TTLRS…QAQKH → MTVRARVEMLAKF in isoform B1e16, isoform B2e16, isoform B3e16, isoform B4e16 and isoform 14. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L49466 mRNA Translation: AAB67290.1
L49467 mRNA Translation: AAF01502.1
L49468 mRNA Translation: AAF01503.1
L49470 mRNA Translation: AAB67291.1
L49471 mRNA Translation: AAB67292.1
L49472 mRNA Translation: AAB67293.1
L48988 mRNA Translation: AAB67283.1
L48989 mRNA Translation: AAB67284.1
L48990 mRNA Translation: AAB67285.1
L48991 mRNA Translation: AAB67286.1
L48992 mRNA Translation: AAB67287.1
L48993 mRNA Translation: AAB67288.1
L49018 mRNA Translation: AAB67289.1
U77779 mRNA Translation: AAB39743.1
AL603651 Genomic DNA No translation available.
BC003747 mRNA Translation: AAH03747.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS22031.1 [Q9QZ47-10]
CCDS52451.1 [Q9QZ47-14]
CCDS52452.1 [Q9QZ47-1]
CCDS52453.1 [Q9QZ47-5]
CCDS52454.1 [Q9QZ47-2]
CCDS52455.1 [Q9QZ47-6]
CCDS52456.1 [Q9QZ47-3]
CCDS85471.1 [Q9QZ47-7]
CCDS85472.1 [Q9QZ47-9]
CCDS85473.1 [Q9QZ47-8]
CCDS85474.1 [Q9QZ47-11]
CCDS85475.1 [Q9QZ47-4]
CCDS85476.1 [Q9QZ47-13]
CCDS85477.1 [Q9QZ47-12]

NCBI Reference Sequences

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RefSeqi
NP_001157137.1, NM_001163665.1
NP_001157140.1, NM_001163668.1
NP_001334476.1, NM_001347547.1
NP_001334477.1, NM_001347548.1
NP_001334478.1, NM_001347549.1
NP_001334479.1, NM_001347550.1
NP_001334480.1, NM_001347551.1
NP_001334481.1, NM_001347552.1
NP_035750.2, NM_011620.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
21957

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21957

UCSC genome browser

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UCSCi
uc009knj.2, mouse [Q9QZ47-10]
uc009knp.2, mouse [Q9QZ47-14]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49466 mRNA Translation: AAB67290.1
L49467 mRNA Translation: AAF01502.1
L49468 mRNA Translation: AAF01503.1
L49470 mRNA Translation: AAB67291.1
L49471 mRNA Translation: AAB67292.1
L49472 mRNA Translation: AAB67293.1
L48988 mRNA Translation: AAB67283.1
L48989 mRNA Translation: AAB67284.1
L48990 mRNA Translation: AAB67285.1
L48991 mRNA Translation: AAB67286.1
L48992 mRNA Translation: AAB67287.1
L48993 mRNA Translation: AAB67288.1
L49018 mRNA Translation: AAB67289.1
U77779 mRNA Translation: AAB39743.1
AL603651 Genomic DNA No translation available.
BC003747 mRNA Translation: AAH03747.1
CCDSiCCDS22031.1 [Q9QZ47-10]
CCDS52451.1 [Q9QZ47-14]
CCDS52452.1 [Q9QZ47-1]
CCDS52453.1 [Q9QZ47-5]
CCDS52454.1 [Q9QZ47-2]
CCDS52455.1 [Q9QZ47-6]
CCDS52456.1 [Q9QZ47-3]
CCDS85471.1 [Q9QZ47-7]
CCDS85472.1 [Q9QZ47-9]
CCDS85473.1 [Q9QZ47-8]
CCDS85474.1 [Q9QZ47-11]
CCDS85475.1 [Q9QZ47-4]
CCDS85476.1 [Q9QZ47-13]
CCDS85477.1 [Q9QZ47-12]
RefSeqiNP_001157137.1, NM_001163665.1
NP_001157140.1, NM_001163668.1
NP_001334476.1, NM_001347547.1
NP_001334477.1, NM_001347548.1
NP_001334478.1, NM_001347549.1
NP_001334479.1, NM_001347550.1
NP_001334480.1, NM_001347551.1
NP_001334481.1, NM_001347552.1
NP_035750.2, NM_011620.3

3D structure databases

SMRiQ9QZ47
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204269, 1 interactor
IntActiQ9QZ47, 1 interactor
MINTiQ9QZ47
STRINGi10090.ENSMUSP00000136278

PTM databases

iPTMnetiQ9QZ47
PhosphoSitePlusiQ9QZ47

Proteomic databases

jPOSTiQ9QZ47
PaxDbiQ9QZ47
PRIDEiQ9QZ47

Genome annotation databases

GeneIDi21957
KEGGimmu:21957
UCSCiuc009knj.2, mouse [Q9QZ47-10]
uc009knp.2, mouse [Q9QZ47-14]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7140
MGIiMGI:109550, Tnnt3

Phylogenomic databases

eggNOGiKOG3634, Eukaryota
InParanoidiQ9QZ47
KOiK12046
OrthoDBi1480247at2759
PhylomeDBiQ9QZ47
TreeFamiTF313321

Enzyme and pathway databases

ReactomeiR-MMU-390522, Striated Muscle Contraction

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
21957, 0 hits in 18 CRISPR screens

Protein Ontology

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PROi
PR:Q9QZ47
RNActiQ9QZ47, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707, TNNT
IPR027708, Tnnt3
IPR001978, Troponin
IPR038077, Troponin_sf
PANTHERiPTHR11521, PTHR11521, 1 hit
PTHR11521:SF4, PTHR11521:SF4, 1 hit
PfamiView protein in Pfam
PF00992, Troponin, 1 hit
SUPFAMiSSF90250, SSF90250, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNNT3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QZ47
Secondary accession number(s): A2A6H7
, A2A6H8, A2A6H9, A2A6I1, A2A6I2, A2A6I4, A2A6I6, A2A6I7, A2A6I9, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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