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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Gene

St6galnac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers CMP-NeuAc with an alpha-2,6-linkage to the GalNAc residues of GalNAc-O-Ser/Thr, Gal-beta-1,3-GalNAc-O-Ser/Thr and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-O-Ser/Thr are substrates. Higher activity towards GalNAc-O-Ser/Thr.1 Publication

Catalytic activityi

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Source: MGI

GO - Biological processi

  • ganglioside biosynthetic process Source: MGI
  • oligosaccharide biosynthetic process Source: MGI
  • protein N-linked glycosylation via asparagine Source: GO_Central

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-4085001 Sialic acid metabolism
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name:
ST6GalNAcI
Sialyltransferase 7A
Short name:
SIAT7-A
Gene namesi
Name:St6galnac1
Synonyms:Siat7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1341826 St6galnac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini34 – 526LumenalSequence analysisAdd BLAST493

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492701 – 526Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi293 ↔ 461By similarity
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QZ39
PaxDbiQ9QZ39
PRIDEiQ9QZ39

PTM databases

iPTMnetiQ9QZ39
PhosphoSitePlusiQ9QZ39

Expressioni

Tissue specificityi

Submaxillary gland, mammary gland, spleen and colon.

Gene expression databases

BgeeiENSMUSG00000009588
GenevisibleiQ9QZ39 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009732

Structurei

3D structure databases

ProteinModelPortaliQ9QZ39
SMRiQ9QZ39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00760000119095
HOGENOMiHOG000231097
HOVERGENiHBG073351
InParanoidiQ9QZ39
KOiK03479
OMAiWLQNIFL
OrthoDBiEOG091G07XX
TreeFamiTF354325

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QZ39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRYCRGLSQ RQAFLLLTVL ALLFILLFVV KDPRAKDSRC QFIWKNDASA
60 70 80 90 100
QENQQKAEPQ VPIMTLSPRV HNKETTSVSS KDLKKQEREA VQGEQAEGKE
110 120 130 140 150
KRKLETIRPA PENPQSKAEP AAKTPVSEHL DKLPRAPGAL STRKTPMATG
160 170 180 190 200
AVPAKKKVVQ ATKSPASSPH PTTRRRQRLK ASEFKSEPRW DFEEEYSLDM
210 220 230 240 250
SSLQTNCSAS VKIKASKSPW LQNIFLPNIT LFLDSGRFTQ SEWNRLEHFA
260 270 280 290 300
PPFGFMELNQ SLVQKVVTRF PPVRQQQLLL ASLPTGYSKC ITCAVVGNGG
310 320 330 340 350
ILNDSRVGRE IDSHDYVFRL SGAVIKGYEQ DVGTRTSFYG FTAFSLTQSI
360 370 380 390 400
LILGRRGFQH VPLGKDVRYL HFLEGTRDYE WLEAMFLNQT LAKTHLSWFR
410 420 430 440 450
HRPQEAFRNA LDLDRYLLLH PDFLRYMKNR FLRSKTLDTA HWRIYRPTTG
460 470 480 490 500
ALLLLTALHL CDKVSAYGFI TEGHQRFSDH YYDTSWKRLI FYINHDFRLE
510 520
RMVWKRLHDE GIIWLYQRPQ SDKAKN
Length:526
Mass (Da):60,734
Last modified:July 27, 2011 - v2
Checksum:i682A5E35E3C142D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40C → R in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti44 – 45WK → LN in CAA72137 (PubMed:10788794).Curated2
Sequence conflicti48A → S in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti53 – 54NQ → IL in CAA72137 (PubMed:10788794).Curated2
Sequence conflicti61V → G in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti75T → A in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti133L → V in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti136A → T in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti378D → N in CAA72137 (PubMed:10788794).Curated1
Sequence conflicti475Q → E in CAA72137 (PubMed:10788794).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11274 mRNA Translation: CAA72137.1
Y10294 Genomic DNA Translation: CAA71341.1
AL645542 Genomic DNA Translation: CAM25277.1
BC141095 mRNA Translation: AAI41096.1
BC145373 mRNA Translation: AAI45374.1
CCDSiCCDS36380.1
PIRiJC7248
RefSeqiNP_035501.2, NM_011371.2
UniGeneiMm.436887
Mm.491644

Genome annotation databases

EnsembliENSMUST00000009732; ENSMUSP00000009732; ENSMUSG00000009588
GeneIDi20445
KEGGimmu:20445
UCSCiuc007mme.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSIA7A_MOUSE
AccessioniPrimary (citable) accession number: Q9QZ39
Secondary accession number(s): A2AA23, Q9JJP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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