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UniProtKB - Q9QZ03 (S39A1_MOUSE)

Entry version 133 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Zinc transporter ZIP1

Gene

Slc39a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-442380 Zinc influx into cells by the SLC39 gene family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name:
ZIP-1
Short name:
mZIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc39a1
Synonyms:Zip1, Zirtl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1353474 Slc39a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 68CytoplasmicSequence analysisAdd BLAST17
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 104ExtracellularSequence analysisAdd BLAST15
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 179CytoplasmicSequence analysisAdd BLAST54
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 206ExtracellularSequence analysis6
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 237CytoplasmicSequence analysis10
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 272ExtracellularSequence analysisAdd BLAST14
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 303CytoplasmicSequence analysis10
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000687641 – 324Zinc transporter ZIP1Add BLAST324

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9QZ03

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QZ03

PRoteomics IDEntifications database

More...PRIDEi		Q9QZ03

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QZ03

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QZ03

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9QZ03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest levels seen in kidney, salivary gland and placenta.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day 17.5 dpc but not in 10.5 dpc and 15.5 dpc. In the small intestine found toward the base of the intestinal villi from 17.5 dpc. In the pancreas, expression was detected from 17.5 dpc and no expression was found in the liver. Also expressed in osteoblasts of developing bone from 15.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000052310 Expressed in 309 organ(s), highest expression level in fibroblast

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QZ03 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000076012

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni190 – 191Heavy metals bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1558 Eukaryota
ENOG4111GP2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000236331

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QZ03

KEGG Orthology (KO)

More...KOi		K14709

Identification of Orthologs from Complete Genome Data

More...OMAi		WHDGLGV

Database of Orthologous Groups

More...OrthoDBi		981397at2759

TreeFam database of animal gene trees

More...TreeFami		TF317098

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003689 ZIP

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02535 Zip, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9QZ03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC 
        60         70         80         90        100
VLRRSGANHE ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL 
       110        120        130        140        150
EALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQTSPP HPEETRALLG 
       160        170        180        190        200
TVNGGPQHWH DGPGIPQAGG TPAAPSALRA CVLVFSLALH SVFEGLAVGL 
       210        220        230        240        250
QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA GCGILFSCMT 
       260        270        280        290        300
PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE 
       310        320 
QRILKVILLL AGFALLTGLL FVQI
Length:324
Mass (Da):34,293
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7962CDB4726D6B3
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB59982 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19S → L in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti29V → G in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti36Missing in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti44C → G in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti137T → S in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti137T → S in AAH05474 (PubMed:15489334).Curated1
Sequence conflicti142 – 143PE → SK in CAB59982 (PubMed:10610721).Curated2
Sequence conflicti177A → T in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti183L → P in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti200 – 203LQRD → FQPN in CAB59982 (PubMed:10610721).Curated4
Sequence conflicti209 – 210EL → DC in CAB59982 (PubMed:10610721).Curated2
Sequence conflicti279A → E in CAB59982 (PubMed:10610721).Curated1
Sequence conflicti288F → Y in CAB59982 (PubMed:10610721).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ243651 Genomic DNA Translation: CAB59982.1 Frameshift.
CH466547 Genomic DNA Translation: EDL15152.1
BC005474 mRNA Translation: AAH05474.1
BC132461 mRNA Translation: AAI32462.1
BC138459 mRNA Translation: AAI38460.1
BC147738 mRNA Translation: AAI47739.1
BC147744 mRNA Translation: AAI47745.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17525.1

NCBI Reference Sequences

More...RefSeqi		NP_038929.2, NM_013901.2
XP_006501623.1, XM_006501560.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310

Database of genes from NCBI RefSeq genomes

More...GeneIDi		30791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:30791

UCSC genome browser

More...UCSCi		uc012csu.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243651 Genomic DNA Translation: CAB59982.1 Frameshift.
CH466547 Genomic DNA Translation: EDL15152.1
BC005474 mRNA Translation: AAH05474.1
BC132461 mRNA Translation: AAI32462.1
BC138459 mRNA Translation: AAI38460.1
BC147738 mRNA Translation: AAI47739.1
BC147744 mRNA Translation: AAI47745.1
CCDSiCCDS17525.1
RefSeqiNP_038929.2, NM_013901.2
XP_006501623.1, XM_006501560.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076012

PTM databases

iPTMnetiQ9QZ03
PhosphoSitePlusiQ9QZ03
SwissPalmiQ9QZ03

Proteomic databases

MaxQBiQ9QZ03
PaxDbiQ9QZ03
PRIDEiQ9QZ03

Genome annotation databases

EnsembliENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310
GeneIDi30791
KEGGimmu:30791
UCSCiuc012csu.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27173
MGIiMGI:1353474 Slc39a1

Phylogenomic databases

eggNOGiKOG1558 Eukaryota
ENOG4111GP2 LUCA
GeneTreeiENSGT00940000157062
HOGENOMiHOG000236331
InParanoidiQ9QZ03
KOiK14709
OMAiWHDGLGV
OrthoDBi981397at2759
TreeFamiTF317098

Enzyme and pathway databases

ReactomeiR-MMU-442380 Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Slc39a1 mouse

Protein Ontology

More...PROi		PR:Q9QZ03

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000052310 Expressed in 309 organ(s), highest expression level in fibroblast
GenevisibleiQ9QZ03 MM

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS39A1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QZ03
Secondary accession number(s): A2RTD4, Q99K44
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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