UniProtKB - Q9QZ03 (S39A1_MOUSE)
Protein
Zinc transporter ZIP1
Gene
Slc39a1
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity).By similarity
GO - Molecular functioni
- signaling receptor binding Source: MGI
- zinc ion transmembrane transporter activity Source: MGI
GO - Biological processi
- embryonic cranial skeleton morphogenesis Source: MGI
- in utero embryonic development Source: MGI
- limb development Source: MGI
- zinc ion transmembrane transport Source: MGI
- zinc ion transport Source: MGI
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-442380, Zinc influx into cells by the SLC39 gene family |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc transporter ZIP1Alternative name(s): Solute carrier family 39 member 1 Zinc-iron-regulated transporter-like Zrt- and Irt-like protein 1 Short name: ZIP-1 Short name: mZIP1 |
Gene namesi | Name:Slc39a1 Synonyms:Zip1, Zirtl |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353474, Slc39a1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 52 – 68 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 90 – 104 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 179 | CytoplasmicSequence analysisAdd BLAST | 54 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 201 – 206 | ExtracellularSequence analysis | 6 | |
Transmembranei | 207 – 227 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 228 – 237 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 272 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 273 – 293 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 303 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 304 – 324 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068764 | 1 – 324 | Zinc transporter ZIP1Add BLAST | 324 |
Proteomic databases
MaxQBi | Q9QZ03 |
PaxDbi | Q9QZ03 |
PRIDEi | Q9QZ03 |
PTM databases
iPTMneti | Q9QZ03 |
PhosphoSitePlusi | Q9QZ03 |
SwissPalmi | Q9QZ03 |
Expressioni
Tissue specificityi
Ubiquitous. Highest levels seen in kidney, salivary gland and placenta.1 Publication
Developmental stagei
Found to be developmentally regulated in the skin where it is expressed in the epidermal layer, excluding the dermis, at embryonic day 17.5 dpc but not in 10.5 dpc and 15.5 dpc. In the small intestine found toward the base of the intestinal villi from 17.5 dpc. In the pancreas, expression was detected from 17.5 dpc and no expression was found in the liver. Also expressed in osteoblasts of developing bone from 15.5 dpc.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000052310, Expressed in fibroblast and 327 other tissues |
Genevisiblei | Q9QZ03, MM |
Interactioni
GO - Molecular functioni
- signaling receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 205964, 1 interactor |
STRINGi | 10090.ENSMUSP00000076012 |
Miscellaneous databases
RNActi | Q9QZ03, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 190 – 191 | Heavy metals bindingBy similarity | 2 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1558, Eukaryota |
GeneTreei | ENSGT00940000157062 |
HOGENOMi | CLU_040462_1_0_1 |
InParanoidi | Q9QZ03 |
OMAi | FGLLAKW |
OrthoDBi | 981397at2759 |
TreeFami | TF317098 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9QZ03-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC
60 70 80 90 100
VLRRSGANHE ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL
110 120 130 140 150
EALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQTSPP HPEETRALLG
160 170 180 190 200
TVNGGPQHWH DGPGIPQAGG TPAAPSALRA CVLVFSLALH SVFEGLAVGL
210 220 230 240 250
QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA GCGILFSCMT
260 270 280 290 300
PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE
310 320
QRILKVILLL AGFALLTGLL FVQI
Sequence cautioni
The sequence CAB59982 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | S → L in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 29 | V → G in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 36 | Missing in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 44 | C → G in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 137 | T → S in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 137 | T → S in AAH05474 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 142 – 143 | PE → SK in CAB59982 (PubMed:10610721).Curated | 2 | |
Sequence conflicti | 177 | A → T in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 183 | L → P in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 200 – 203 | LQRD → FQPN in CAB59982 (PubMed:10610721).Curated | 4 | |
Sequence conflicti | 209 – 210 | EL → DC in CAB59982 (PubMed:10610721).Curated | 2 | |
Sequence conflicti | 279 | A → E in CAB59982 (PubMed:10610721).Curated | 1 | |
Sequence conflicti | 288 | F → Y in CAB59982 (PubMed:10610721).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ243651 Genomic DNA Translation: CAB59982.1 Frameshift. CH466547 Genomic DNA Translation: EDL15152.1 BC005474 mRNA Translation: AAH05474.1 BC132461 mRNA Translation: AAI32462.1 BC138459 mRNA Translation: AAI38460.1 BC147738 mRNA Translation: AAI47739.1 BC147744 mRNA Translation: AAI47745.1 |
CCDSi | CCDS17525.1 |
RefSeqi | NP_038929.2, NM_013901.2 XP_006501623.1, XM_006501560.3 |
Genome annotation databases
Ensembli | ENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310 |
GeneIDi | 30791 |
KEGGi | mmu:30791 |
UCSCi | uc012csu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ243651 Genomic DNA Translation: CAB59982.1 Frameshift. CH466547 Genomic DNA Translation: EDL15152.1 BC005474 mRNA Translation: AAH05474.1 BC132461 mRNA Translation: AAI32462.1 BC138459 mRNA Translation: AAI38460.1 BC147738 mRNA Translation: AAI47739.1 BC147744 mRNA Translation: AAI47745.1 |
CCDSi | CCDS17525.1 |
RefSeqi | NP_038929.2, NM_013901.2 XP_006501623.1, XM_006501560.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 205964, 1 interactor |
STRINGi | 10090.ENSMUSP00000076012 |
PTM databases
iPTMneti | Q9QZ03 |
PhosphoSitePlusi | Q9QZ03 |
SwissPalmi | Q9QZ03 |
Proteomic databases
MaxQBi | Q9QZ03 |
PaxDbi | Q9QZ03 |
PRIDEi | Q9QZ03 |
Protocols and materials databases
Antibodypediai | 20389, 97 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310 |
GeneIDi | 30791 |
KEGGi | mmu:30791 |
UCSCi | uc012csu.1, mouse |
Organism-specific databases
CTDi | 27173 |
MGIi | MGI:1353474, Slc39a1 |
Phylogenomic databases
eggNOGi | KOG1558, Eukaryota |
GeneTreei | ENSGT00940000157062 |
HOGENOMi | CLU_040462_1_0_1 |
InParanoidi | Q9QZ03 |
OMAi | FGLLAKW |
OrthoDBi | 981397at2759 |
TreeFami | TF317098 |
Enzyme and pathway databases
Reactomei | R-MMU-442380, Zinc influx into cells by the SLC39 gene family |
Miscellaneous databases
BioGRID-ORCSi | 30791, 1 hit in 17 CRISPR screens |
ChiTaRSi | Slc39a1, mouse |
PROi | PR:Q9QZ03 |
RNActi | Q9QZ03, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052310, Expressed in fibroblast and 327 other tissues |
Genevisiblei | Q9QZ03, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S39A1_MOUSE | |
Accessioni | Q9QZ03Primary (citable) accession number: Q9QZ03 Secondary accession number(s): A2RTD4, Q99K44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families