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Protein

Dickkopf-related protein 2

Gene

Dkk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.1 Publication

GO - Molecular functioni

  • co-receptor binding Source: ParkinsonsUK-UCL
  • receptor antagonist activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Names & Taxonomyi

Protein namesi
Recommended name:
Dickkopf-related protein 2
Short name:
Dickkopf-2
Short name:
Dkk-2
Short name:
mDkk-2
Gene namesi
Name:Dkk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1890663 Dkk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000722134 – 259Dickkopf-related protein 2Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi183 ↔ 1951 Publication
Disulfide bondi189 ↔ 2041 Publication
Disulfide bondi194 ↔ 2311 Publication
Disulfide bondi214 ↔ 2391 Publication
Disulfide bondi233 ↔ 2561 Publication

Post-translational modificationi

May be proteolytically processed by a furin-like protease.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QYZ8
PaxDbiQ9QYZ8
PRIDEiQ9QYZ8

PTM databases

PhosphoSitePlusiQ9QYZ8

Expressioni

Developmental stagei

Expressed in the developing cochlea.1 Publication

Gene expression databases

BgeeiENSMUSG00000028031 Expressed in 214 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_DKK2
GenevisibleiQ9QYZ8 MM

Interactioni

Subunit structurei

Interacts with LRP5 and LRP6.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029665

Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9QYZ8
SMRiQ9QYZ8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QYZ8

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni78 – 127DKK-type Cys-1Add BLAST50
Regioni183 – 256DKK-type Cys-2Add BLAST74

Domaini

The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.

Sequence similaritiesi

Belongs to the dickkopf family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000007000
HOGENOMiHOG000246998
HOVERGENiHBG000441
InParanoidiQ9QYZ8
KOiK02165
OMAiNRCNNGI
OrthoDBiEOG091G0H13
TreeFamiTF330916

Family and domain databases

InterProiView protein in InterPro
IPR006796 Dickkopf_N
IPR039863 DKK-like
PANTHERiPTHR12113 PTHR12113, 1 hit
PfamiView protein in Pfam
PF04706 Dickkopf_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYZ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALMRVKDS SRCLLLLAAV LMVESSQLGS SRAKLNSIKS SLGGETPAQS
60 70 80 90 100
ANRSAGMNQG LAFGGSKKGK SLGQAYPCSS DKECEVGRYC HSPHQGSSAC
110 120 130 140 150
MLCRRKKKRC HRDGMCCPGT RCNNGICIPV TESILTPHIP ALDGTRHRDR
160 170 180 190 200
NHGHYSNHDL GWQNLGRPHS KMPHIKGHEG DPCLRSSDCI DGFCCARHFW
210 220 230 240 250
TKICKPVLHQ GEVCTKQRKK GSHGLEIFQR CDCAKGLSCK VWKDATYSSK

ARLHVCQKI
Length:259
Mass (Da):28,432
Last modified:October 3, 2012 - v2
Checksum:iE649ED8E3BC7E8E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → P in CAB60110 (PubMed:10495270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243963 mRNA Translation: CAB60110.1
AK028225 mRNA Translation: BAC25824.1
AK031749 mRNA Translation: BAC27536.1
AC127260 Genomic DNA No translation available.
CH466532 Genomic DNA Translation: EDL12195.1
BC096448 mRNA Translation: AAH96448.1
CCDSiCCDS17844.1
RefSeqiNP_064661.2, NM_020265.4
UniGeneiMm.103593

Genome annotation databases

EnsembliENSMUST00000029665; ENSMUSP00000029665; ENSMUSG00000028031
GeneIDi56811
KEGGimmu:56811
UCSCiuc008rjw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243963 mRNA Translation: CAB60110.1
AK028225 mRNA Translation: BAC25824.1
AK031749 mRNA Translation: BAC27536.1
AC127260 Genomic DNA No translation available.
CH466532 Genomic DNA Translation: EDL12195.1
BC096448 mRNA Translation: AAH96448.1
CCDSiCCDS17844.1
RefSeqiNP_064661.2, NM_020265.4
UniGeneiMm.103593

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JTKNMR-A172-259[»]
ProteinModelPortaliQ9QYZ8
SMRiQ9QYZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029665

PTM databases

PhosphoSitePlusiQ9QYZ8

Proteomic databases

MaxQBiQ9QYZ8
PaxDbiQ9QYZ8
PRIDEiQ9QYZ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029665; ENSMUSP00000029665; ENSMUSG00000028031
GeneIDi56811
KEGGimmu:56811
UCSCiuc008rjw.2 mouse

Organism-specific databases

CTDi27123
MGIiMGI:1890663 Dkk2

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000007000
HOGENOMiHOG000246998
HOVERGENiHBG000441
InParanoidiQ9QYZ8
KOiK02165
OMAiNRCNNGI
OrthoDBiEOG091G0H13
TreeFamiTF330916

Enzyme and pathway databases

ReactomeiR-MMU-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Miscellaneous databases

EvolutionaryTraceiQ9QYZ8
PROiPR:Q9QYZ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028031 Expressed in 214 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_DKK2
GenevisibleiQ9QYZ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR006796 Dickkopf_N
IPR039863 DKK-like
PANTHERiPTHR12113 PTHR12113, 1 hit
PfamiView protein in Pfam
PF04706 Dickkopf_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDKK2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYZ8
Secondary accession number(s): Q8BFW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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