Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sperm motility kinase 2A

Gene

Smok2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in sperm motility, especially in the regulation of flagellar function.1 Publication

Miscellaneous

Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57ATPPROSITE-ProRule annotation1
Active sitei147Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm motility kinase 2A (EC:2.7.11.1)
Gene namesi
Name:Smok2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351487 Smok2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078691 – 504Sperm motility kinase 2AAdd BLAST504

Proteomic databases

PaxDbiQ9QYZ6
PRIDEiQ9QYZ6

PTM databases

iPTMnetiQ9QYZ6
PhosphoSitePlusiQ9QYZ6

Expressioni

Tissue specificityi

Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp).1 Publication

Gene expression databases

CleanExiMM_SMOK2A

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094432

Structurei

3D structure databases

ProteinModelPortaliQ9QYZ6
SMRiQ9QYZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 276Protein kinasePROSITE-ProRule annotationAdd BLAST249
Domaini294 – 334UBAAdd BLAST41

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
HOGENOMiHOG000154351
HOVERGENiHBG108494
InParanoidiQ9QYZ6
PhylomeDBiQ9QYZ6

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9QYZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSGSQQKSE KLRSKPPFSE MENFHAQYEM LGTIGHGGST KVKLARHRLT
60 70 80 90 100
GTHVAVKMIP KREYWCKPLM SEAELLMMAD HPNIISLLQV IETKKKVYLI
110 120 130 140 150
MELCEGKSLY QHIRNAGYLQ EDEARALFKQ LLSAINYCRN QGIVHRDLKP
160 170 180 190 200
DNIMVEKDGR VKIIDFGLGI QVKPGQKLNL FCGTYPFSAP EVLLSRPYDG
210 220 230 240 250
PKIDVWTLGV VLYFMVTGKI PFDAASIEKL RKQIVAGKYS VPCRLSVKLH
260 270 280 290 300
HLITLLMTDN PELRPTVAEV MMHPWVTKGS GVFPDPCEEQ IPLKPDPAIV
310 320 330 340 350
KAMGHIGFQA QDIEDSLRQR KFNETMASYC LLKKQLLKEC DRPIRAQPMN
360 370 380 390 400
PSVTPFPSLV DTPTFHLGLR RRETEPTSLR LSANRQMSVC GRSTSKKRDR
410 420 430 440 450
SFSWPGVLSR PINITPTMDQ THTCTRSVPC INSNFCIIHP NSSDESTEGH
460 470 480 490 500
TSASAEDKPV RSRGWPRGIK GWTSKIGNAM RKLCCCIPSN ETSHLGQRRV

SPKK
Length:504
Mass (Da):56,787
Last modified:May 1, 2000 - v1
Checksum:i596F27F4804902C8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8M0G5E8M0_MOUSE
MCG52533
Smok2a mCG_52533
504Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245453 mRNA Translation: CAB61341.1
CCDSiCCDS49951.1
UniGeneiMm.371809

Similar proteinsi

Entry informationi

Entry nameiSMK2A_MOUSE
AccessioniPrimary (citable) accession number: Q9QYZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again