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Protein

Endothelial cell-specific molecule 1

Gene

Esm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-specific molecule 1
Short name:
ESM-1
Gene namesi
Name:Esm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1918940 Esm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001439522 – 184Endothelial cell-specific molecule 1Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi157O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and dermatan sulfate.By similarity

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

EPDiQ9QYY7
PaxDbiQ9QYY7
PRIDEiQ9QYY7

PTM databases

PhosphoSitePlusiQ9QYY7

Expressioni

Gene expression databases

BgeeiENSMUSG00000042379 Expressed in 143 organ(s), highest expression level in pineal body
CleanExiMM_ESM1
ExpressionAtlasiQ9QYY7 baseline and differential
GenevisibleiQ9QYY7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040187

Structurei

3D structure databases

ProteinModelPortaliQ9QYY7
SMRiQ9QYY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 102IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000018810
HOGENOMiHOG000273901
HOVERGENiHBG005610
InParanoidiQ9QYY7
OMAiAVDCPEH
OrthoDBiEOG091G0M9A
PhylomeDBiQ9QYY7

Family and domain databases

InterProiView protein in InterPro
IPR038850 ESM1
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
PANTHERiPTHR15428 PTHR15428, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLLLLTTL LVPLHLGMAW SAKYAVDCPE HCDKTECRSS LRCKRTVLDD
60 70 80 90 100
CGCCQVCAAG PGETCYRTVS GMDGVKCGPG LKCHFYSEED DFGDEFGICK
110 120 130 140 150
DCPYGTFGME CKETCNCQSG ICDRVTGRCL DFPFFQYAAA KSPSRTSASH
160 170 180
TERDSASGDG NAVREEIGEG NAARPSVMKW LNPR
Length:184
Mass (Da):20,043
Last modified:May 1, 2000 - v1
Checksum:i0F54F7629678D278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249354 mRNA Translation: CAB60730.1
AK002913 mRNA Translation: BAB22452.1
BC051919 mRNA Translation: AAH51919.1
CCDSiCCDS26784.1
RefSeqiNP_076101.1, NM_023612.3
UniGeneiMm.38929

Genome annotation databases

EnsembliENSMUST00000038144; ENSMUSP00000040187; ENSMUSG00000042379
GeneIDi71690
KEGGimmu:71690
UCSCiuc007rxe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249354 mRNA Translation: CAB60730.1
AK002913 mRNA Translation: BAB22452.1
BC051919 mRNA Translation: AAH51919.1
CCDSiCCDS26784.1
RefSeqiNP_076101.1, NM_023612.3
UniGeneiMm.38929

3D structure databases

ProteinModelPortaliQ9QYY7
SMRiQ9QYY7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040187

PTM databases

PhosphoSitePlusiQ9QYY7

Proteomic databases

EPDiQ9QYY7
PaxDbiQ9QYY7
PRIDEiQ9QYY7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038144; ENSMUSP00000040187; ENSMUSG00000042379
GeneIDi71690
KEGGimmu:71690
UCSCiuc007rxe.1 mouse

Organism-specific databases

CTDi11082
MGIiMGI:1918940 Esm1

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000018810
HOGENOMiHOG000273901
HOVERGENiHBG005610
InParanoidiQ9QYY7
OMAiAVDCPEH
OrthoDBiEOG091G0M9A
PhylomeDBiQ9QYY7

Miscellaneous databases

PROiPR:Q9QYY7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042379 Expressed in 143 organ(s), highest expression level in pineal body
CleanExiMM_ESM1
ExpressionAtlasiQ9QYY7 baseline and differential
GenevisibleiQ9QYY7 MM

Family and domain databases

InterProiView protein in InterPro
IPR038850 ESM1
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
PANTHERiPTHR15428 PTHR15428, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESM1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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