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Entry version 158 (16 Oct 2019)
Sequence version 4 (09 Jan 2013)
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Protein

Protein piccolo

Gene

Pclo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (PubMed:28231469) (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri532 – 556C4-typeSequence analysisAdd BLAST25
Zinc fingeri997 – 1020C4-typeSequence analysisAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Calcium/phospholipid-binding, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein piccoloCurated
Alternative name(s):
Aczonin1 Publication
Brain-derived HLMN protein
Multidomain presynaptic cytomatrix protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PcloImported
Synonyms:Acz1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349390 Pclo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockdown of both Bassoon/BSN and Piccolo/PCLO leads to the formation of presynaptic autophagosomes.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582511 – 5068Protein piccoloAdd BLAST5068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei212PhosphoserineCombined sources1
Modified residuei844PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei860PhosphothreonineCombined sources1
Modified residuei1120PhosphothreonineCombined sources1
Modified residuei1292PhosphoserineCombined sources1
Modified residuei1302PhosphoserineCombined sources1
Modified residuei1303PhosphoserineCombined sources1
Modified residuei1332PhosphoserineCombined sources1
Modified residuei1334PhosphoserineCombined sources1
Modified residuei1337PhosphoserineCombined sources1
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1341PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1451PhosphoserineCombined sources1
Modified residuei1452PhosphoserineCombined sources1
Modified residuei1454PhosphoserineCombined sources1
Modified residuei1457PhosphoserineCombined sources1
Modified residuei1481PhosphoserineCombined sources1
Modified residuei1484PhosphoserineCombined sources1
Modified residuei1505PhosphoserineBy similarity1
Modified residuei1507PhosphoserineBy similarity1
Modified residuei1552PhosphothreonineCombined sources1
Modified residuei1553PhosphoserineCombined sources1
Modified residuei1563PhosphoserineCombined sources1
Modified residuei1575PhosphoserineCombined sources1
Modified residuei1638PhosphoserineBy similarity1
Modified residuei1640PhosphothreonineBy similarity1
Modified residuei1642PhosphoserineCombined sources1
Modified residuei1647PhosphoserineCombined sources1
Modified residuei1708PhosphoserineCombined sources1
Modified residuei1709PhosphoserineCombined sources1
Modified residuei1760PhosphothreonineCombined sources1
Modified residuei1766PhosphoserineCombined sources1
Modified residuei1795PhosphoserineCombined sources1
Modified residuei1800PhosphoserineCombined sources1
Modified residuei1808PhosphoserineCombined sources1
Modified residuei1829PhosphoserineCombined sources1
Modified residuei2495PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi2686O-linked (GlcNAc) threonine1 Publication1
Glycosylationi2960O-linked (GlcNAc) serine1 Publication1
Modified residuei2998PhosphothreonineCombined sources1
Modified residuei3358PhosphoserineCombined sources1
Modified residuei3372PhosphoserineCombined sources1
Modified residuei3376PhosphothreonineCombined sources1
Modified residuei3403PhosphothreonineCombined sources1
Modified residuei3506PhosphoserineCombined sources1
Modified residuei3514PhosphoserineCombined sources1
Modified residuei3545PhosphoserineCombined sources1
Modified residuei3549PhosphoserineCombined sources1
Modified residuei3555PhosphoserineBy similarity1
Modified residuei3558PhosphoserineCombined sources1
Modified residuei3561PhosphoserineBy similarity1
Modified residuei3582PhosphoserineCombined sources1
Modified residuei3608PhosphoserineBy similarity1
Modified residuei3610PhosphoserineCombined sources1
Modified residuei3616PhosphoserineCombined sources1
Modified residuei3763PhosphoserineBy similarity1
Modified residuei4016PhosphoserineCombined sources1
Modified residuei4042PhosphoserineCombined sources1
Modified residuei4132PhosphoserineCombined sources1
Modified residuei4286PhosphoserineCombined sources1
Modified residuei4290PhosphoserineCombined sources1
Modified residuei4293PhosphoserineCombined sources1
Modified residuei4322PhosphoserineBy similarity1
Modified residuei4358PhosphoserineCombined sources1
Modified residuei4592PhosphoserineCombined sources1
Modified residuei4706PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9QYX7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9QYX7

PeptideAtlas

More...
PeptideAtlasi
Q9QYX7

PRoteomics IDEntifications database

More...
PRIDEi
Q9QYX7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QYX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QYX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000061601 Expressed in 179 organ(s), highest expression level in cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9QYX7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9QYX7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BSN, ERC2/CAST1, RIMS1 and UNC13A (PubMed:10508862, PubMed:12401793).

Interacts (via C-terminus) with TRIO (via N-terminus) (By similarity).

Interacts with CTBP1 (By similarity).

Interacts with SIAH1; this interaction negatively regulates SIAH1 E3 ligase activity (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
205033, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9QYX7, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9QYX7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000030691

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9QYX7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4424 – 4518PDZPROSITE-ProRule annotationAdd BLAST95
Domaini4637 – 4735C2 1PROSITE-ProRule annotationAdd BLAST99
Domaini4952 – 5042C2 2PROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni401 – 50010 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-XAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2335 – 2359Poly-ProAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri532 – 556C4-typeSequence analysisAdd BLAST25
Zinc fingeri997 – 1020C4-typeSequence analysisAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060 Eukaryota
ENOG410ZNB1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00620000087961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168263

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QYX7

KEGG Orthology (KO)

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KOi
K16882

Identification of Orthologs from Complete Genome Data

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OMAi
SHAHSGP

Database of Orthologous Groups

More...
OrthoDBi
15051at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15774 FYVE1_PCLO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 2 hits
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR042720 PCLO_FYVE1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030629 Piccolo
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR14113:SF6 PTHR14113:SF6, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit
PF05715 zf-piccolo, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QYX7-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER
60 70 80 90 100
RQIAAVMSRA QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG
110 120 130 140 150
RPPQHGLSKS RTTDTFRSEQ KLPGRSPSTI SLKESKSRTD FKEEYKSSMM
160 170 180 190 200
PGFFSDVNPL SAVSSVVNKF NPFDLISDSE AVQEETTKKQ KVAQKDQGKS
210 220 230 240 250
EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ AEKTKPQAPG
260 270 280 290 300
TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP
310 320 330 340 350
AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP
360 370 380 390 400
GTAKLPAQQP GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI
410 420 430 440 450
PAKPQPQQPV ATKPQPQQPA PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT
460 470 480 490 500
PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT PAKPQPQQPG LGKPSAQQPS
510 520 530 540 550
KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL LLHTPEKANF
560 570 580 590 600
NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP
610 620 630 640 650
QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK
660 670 680 690 700
QPTLHGPTPA TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP
710 720 730 740 750
KTTETLTDSP SSAAATSKPA ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP
760 770 780 790 800
PTGDTITPLD SKAMPRPASD SKIVSHPGPT SESKDPVQKK EEPKKAQTKV
810 820 830 840 850
TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS RRFSLNLGGI
860 870 880 890 900
ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA
910 920 930 940 950
PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP
960 970 980 990 1000
VQAPTVKKAE KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC
1010 1020 1030 1040 1050
RTELNVGSQD PPNFNTCTEC KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ
1060 1070 1080 1090 1100
RAISGQLGDM DKMPPASSGP KASPVPAPAE PPPQKTPTAA HAKGKKKETE
1110 1120 1130 1140 1150
VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV SVLPEKKPSE
1160 1170 1180 1190 1200
EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD
1210 1220 1230 1240 1250
LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE
1260 1270 1280 1290 1300
SRDVTQPQAE GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG
1310 1320 1330 1340 1350
YSSDGISGSL GEIPSLIPSD EKDLLKGLKK DSFSQESSPS SPSDLAKLES
1360 1370 1380 1390 1400
TVLSILEAQA STLVGEKAEK KTQPQKVSPE QPQDQQKTQT PSETRDISIS
1410 1420 1430 1440 1450
EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP RRASYDSVED
1460 1470 1480 1490 1500
SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA
1510 1520 1530 1540 1550
DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS
1560 1570 1580 1590 1600
STSFDDDAGR RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR
1610 1620 1630 1640 1650
RFKTIELNST VTDKYSAESS QKKTTLYFDE EPELEMESLT DSPEDRSRGE
1660 1670 1680 1690 1700
GSSSLHASSF TPGTSPTSVS SLDEDSDSSP SHKKGESKQQ RKARHRSHGP
1710 1720 1730 1740 1750
LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK KSKKDKDELR
1760 1770 1780 1790 1800
AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES
1810 1820 1830 1840 1850
DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE
1860 1870 1880 1890 1900
EMYEEMMHKP HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY
1910 1920 1930 1940 1950
NGSVDGSLLT RQDEQNGFMQ QRGREQKIRL QEQIYDDPMQ KITDLQKEFY
1960 1970 1980 1990 2000
ELESLHSIVP QEDIVSSSYI IPESHEIVDL GSMVTSTSEE KKLLDADAAY
2010 2020 2030 2040 2050
EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS LTSSILSGAS
2060 2070 2080 2090 2100
LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT
2110 2120 2130 2140 2150
YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD
2160 2170 2180 2190 2200
VITKFKDSEE ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF
2210 2220 2230 2240 2250
PGIAPSITES VATKPERPQA DTISTDLPIS EKELIKGKKE TGDGIILEVL
2260 2270 2280 2290 2300
DAYKDKREES EAELTKISLP ETGLAPTPSS QTKEQPGSPH SVSGEILGQE
2310 2320 2330 2340 2350
KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP PPPPPPPPPP
2360 2370 2380 2390 2400
PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA
2410 2420 2430 2440 2450
RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP
2460 2470 2480 2490 2500
EIPVTTQKTT DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK
2510 2520 2530 2540 2550
SSPRYSKSLM ETYVVITLPS EPGTPTDSSA AQAITSWPLG SPPKDLVSLE
2560 2570 2580 2590 2600
TVFSVVPPMT STEIPSASQP TLYTSGALGT FSVTPAVTAS LFQTVPTSLT
2610 2620 2630 2640 2650
QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR HQYKENGKLP
2660 2670 2680 2690 2700
LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ
2710 2720 2730 2740 2750
PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS
2760 2770 2780 2790 2800
PLQLTTSKHT ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV
2810 2820 2830 2840 2850
TVPPVGVTNG WTDSTISQGI TDGEVVDLST SKSHRTVVTM DESTSNVVTK
2860 2870 2880 2890 2900
IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR SCTAQQPATT LPEDRFGYRD
2910 2920 2930 2940 2950
DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN AFDYSGGTEA
2960 2970 2980 2990 3000
AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP
3010 3020 3030 3040 3050
PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI
3060 3070 3080 3090 3100
HTTDAITSLS ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME
3110 3120 3130 3140 3150
TLPAETMDSV PTLTTASEVF SEVVGEESTL LIVPDEDKQQ QQLDLERELL
3160 3170 3180 3190 3200
ELEKIKQQRF AEELEWERQE IQRFREQEKI MVQKKLEELQ SMKQHLLYQQ
3210 3220 3230 3240 3250
EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK LRQIYQYNYE
3260 3270 3280 3290 3300
PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ
3310 3320 3330 3340 3350
GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG
3360 3370 3380 3390 3400
QYDEMGESMA DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS
3410 3420 3430 3440 3450
VQTDDEDQDE WDMPSRSRRK ARTGKYGDST AEGDKTKPPS KVSSVAVQTV
3460 3470 3480 3490 3500
AEISVQTEPL GTIRTPSIRA RVDAKVEIIK HISAPEKTYK GGSLGCQTET
3510 3520 3530 3540 3550
DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV QLAPSPPKSP
3560 3570 3580 3590 3600
KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK
3610 3620 3630 3640 3650
TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR
3660 3670 3680 3690 3700
TLPNPPPEEA STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL
3710 3720 3730 3740 3750
VERESAKLRK KQAELDEEEK EIDAKLRYLE MGINRRKEAL LKEREKRERA
3760 3770 3780 3790 3800
YLQGVAEDRD YMSDSEVSST RPSRVESQHG IERPRTAPQT EFSQFIPPQT
3810 3820 3830 3840 3850
QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ TLYHQQVSPY
3860 3870 3880 3890 3900
QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP
3910 3920 3930 3940 3950
KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA
3960 3970 3980 3990 4000
SSPISSISAD SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD
4010 4020 4030 4040 4050
LSKTDRLLRT TETRRSQEVT DFLAPLQTSS RLHSYVKAEE DSMEDPYELK
4060 4070 4080 4090 4100
LLKHQIKQEF RRGTESLDHL AGLSHYYHAD TSYRHFPKSE KYSISRLTLE
4110 4120 4130 4140 4150
KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL EPDYPTYLSS
4160 4170 4180 4190 4200
STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR
4210 4220 4230 4240 4250
SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE
4260 4270 4280 4290 4300
ALDVSFGHSS SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG
4310 4320 4330 4340 4350
MARAAAGPLP PISADTRDQF GSSHSLPEVQ QHMREESRTR GYDRDIAFIM
4360 4370 4380 4390 4400
DDFQHAMSDS EAYHLRREET DWFDKPRESR LENGHGLDRK LPERLVHSRP
4410 4420 4430 4440 4450
LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG LGIRIVGGKE
4460 4470 4480 4490 4500
IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ
4510 4520 4530 4540 4550
SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK
4560 4570 4580 4590 4600
QLAAELQKVS LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS
4610 4620 4630 4640 4650
VSKKKHGGSK PTDVSKTASH PITGEIQLQI NYDLGNLIIH ILQARNLVPR
4660 4670 4680 4690 4700
DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE YKRRTKYVQK SLNPEWNQTV
4710 4720 4730 4740 4750
IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS TSHLDNTPRW
4760 4770 4780 4790 4800
YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI
4810 4820 4830 4840 4850
EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA
4860 4870 4880 4890 4900
VQQLRIQPTK PTNHRPAETS VSTGSSGSSV GSGYSVDSEG SSCVAGEPNL
4910 4920 4930 4940 4950
LPIPRIGKMG QNGQDPVKQP GMGAADTEAK TQVMGEIKLA LKKEMKTDGE
4960 4970 4980 4990 5000
QLIVEILQCR NITYKFKSPD HLPDLYVKIY VINIATQKKV IKKKTRVCRH
5010 5020 5030 5040 5050
DREPSFNETF RFSLSPAGHS LQILLFSNGG KFMKKTLIGE ACIWLDKVDL
5060
RKRIVNWHKL LMSPTQTH
Length:5,068
Mass (Da):550,834
Last modified:January 9, 2013 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBF54D47501AC79A
GO
Isoform 2 (identifier: Q9QYX7-2) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     4859-4863: TKPTN → SKRRK
     4864-5068: Missing.

Show »
Length:4,863
Mass (Da):528,257
Checksum:i6F9A9B68DCBA59D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2E0S4R2E0_MOUSE
Protein piccolo
Pclo
1,592Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC53723 differs from that shown. Unlikely isoform. Several sequence problems.Curated
The sequence BAC53724 differs from that shown. Unlikely isoform. Several sequence problems.Curated
The sequence CAB60731 differs from that shown. Probable cloning artifact.Curated
The sequence CAB60732 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti156D → E in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti156D → E in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti366A → S in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti366A → S in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti438H → Q in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti438H → Q in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti438H → Q in BAC53723 (PubMed:12401793).Curated1
Sequence conflicti438H → Q in BAC53724 (PubMed:12401793).Curated1
Sequence conflicti478H → Q in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti478H → Q in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti478H → Q in BAC53723 (PubMed:12401793).Curated1
Sequence conflicti478H → Q in BAC53724 (PubMed:12401793).Curated1
Sequence conflicti923P → Q in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti923P → Q in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti923P → Q in BAC53723 (PubMed:12401793).Curated1
Sequence conflicti923P → Q in BAC53724 (PubMed:12401793).Curated1
Sequence conflicti951V → A in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti951V → A in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti965P → H in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti965P → H in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti1920Q → P in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti1920Q → P in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti1931Q → R in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti1931Q → R in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti2297L → S in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti2297L → S in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti2335 – 2346Missing in BAC53723 (PubMed:12401793).CuratedAdd BLAST12
Sequence conflicti2335 – 2346Missing in BAC53724 (PubMed:12401793).CuratedAdd BLAST12
Sequence conflicti2855E → D in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti2855E → D in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti4042S → P in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti4042S → P in CAB60732 (PubMed:10508862).Curated1
Sequence conflicti4670 – 4678Missing in BAC53724 (PubMed:12401793).Curated9
Sequence conflicti5062M → V in CAB60731 (PubMed:10508862).Curated1
Sequence conflicti5062M → V in CAB60732 (PubMed:10508862).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0039284859 – 4863TKPTN → SKRRK in isoform 2. 2 Publications5
Alternative sequenceiVSP_0039294864 – 5068Missing in isoform 2. 2 PublicationsAdd BLAST205

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y19185 mRNA Translation: CAB60731.2 Sequence problems.
Y19186 mRNA Translation: CAB60732.2 Sequence problems.
AB083477 mRNA Translation: BAC53723.1 Sequence problems.
AB083478 mRNA Translation: BAC53724.1 Sequence problems.
AC125043 Genomic DNA No translation available.
AC125533 Genomic DNA No translation available.
AC144480 Genomic DNA No translation available.
AC144625 Genomic DNA No translation available.
AF181269 mRNA Translation: AAD55786.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51415.1 [Q9QYX7-1]
CCDS59667.1 [Q9QYX7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001104266.1, NM_001110796.2 [Q9QYX7-2]
NP_036125.4, NM_011995.4 [Q9QYX7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000030691; ENSMUSP00000030691; ENSMUSG00000061601 [Q9QYX7-1]
ENSMUST00000182407; ENSMUSP00000138419; ENSMUSG00000061601 [Q9QYX7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26875

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:26875

UCSC genome browser

More...
UCSCi
uc008wmh.3 mouse [Q9QYX7-2]
uc008wmi.2 mouse [Q9QYX7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19185 mRNA Translation: CAB60731.2 Sequence problems.
Y19186 mRNA Translation: CAB60732.2 Sequence problems.
AB083477 mRNA Translation: BAC53723.1 Sequence problems.
AB083478 mRNA Translation: BAC53724.1 Sequence problems.
AC125043 Genomic DNA No translation available.
AC125533 Genomic DNA No translation available.
AC144480 Genomic DNA No translation available.
AC144625 Genomic DNA No translation available.
AF181269 mRNA Translation: AAD55786.2
CCDSiCCDS51415.1 [Q9QYX7-1]
CCDS59667.1 [Q9QYX7-2]
RefSeqiNP_001104266.1, NM_001110796.2 [Q9QYX7-2]
NP_036125.4, NM_011995.4 [Q9QYX7-1]

3D structure databases

SMRiQ9QYX7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi205033, 6 interactors
IntActiQ9QYX7, 3 interactors
MINTiQ9QYX7
STRINGi10090.ENSMUSP00000030691

PTM databases

iPTMnetiQ9QYX7
PhosphoSitePlusiQ9QYX7

Proteomic databases

jPOSTiQ9QYX7
PaxDbiQ9QYX7
PeptideAtlasiQ9QYX7
PRIDEiQ9QYX7

Genome annotation databases

EnsembliENSMUST00000030691; ENSMUSP00000030691; ENSMUSG00000061601 [Q9QYX7-1]
ENSMUST00000182407; ENSMUSP00000138419; ENSMUSG00000061601 [Q9QYX7-2]
GeneIDi26875
KEGGimmu:26875
UCSCiuc008wmh.3 mouse [Q9QYX7-2]
uc008wmi.2 mouse [Q9QYX7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27445
MGIiMGI:1349390 Pclo

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
ENOG410ZNB1 LUCA
GeneTreeiENSGT00620000087961
HOGENOMiHOG000168263
InParanoidiQ9QYX7
KOiK16882
OMAiSHAHSGP
OrthoDBi15051at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pclo mouse

Protein Ontology

More...
PROi
PR:Q9QYX7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000061601 Expressed in 179 organ(s), highest expression level in cingulate cortex
ExpressionAtlasiQ9QYX7 baseline and differential
GenevisibleiQ9QYX7 MM

Family and domain databases

CDDicd15774 FYVE1_PCLO, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR042720 PCLO_FYVE1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030629 Piccolo
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR14113:SF6 PTHR14113:SF6, 3 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit
PF05715 zf-piccolo, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCLO_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QYX7
Secondary accession number(s): E9QK94
, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 9, 2013
Last modified: October 16, 2019
This is version 158 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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