UniProtKB - Q9QYW0 (AATF_RAT)
Protein
Protein AATF
Gene
Aatf
Organism
Rattus norvegicus (Rat)
Status
Functioni
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation.By similarity1 Publication
GO - Molecular functioni
- leucine zipper domain binding Source: RGD
- protein kinase binding Source: RGD
- tau protein binding Source: RGD
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell adhesion Source: RGD
- cellular response to DNA damage stimulus Source: RGD
- embryonic cleavage Source: RGD
- negative regulation of amyloid precursor protein biosynthetic process Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of apoptotic signaling pathway Source: RGD
- negative regulation of reactive oxygen species metabolic process Source: RGD
- negative regulation of superoxide anion generation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of mitotic cell cycle Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- ribosome biogenesis Source: RGD
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Protein AATFAlternative name(s): Apoptosis-antagonizing transcription factor |
Gene namesi | Name:Aatf |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620685, Aatf |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Golgi apparatus
- Golgi apparatus Source: RGD
Nucleus
- nucleolus Source: RGD
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000056618 | 2 – 523 | Protein AATFAdd BLAST | 522 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 62 | PhosphoserineBy similarity | 1 | |
Modified residuei | 167 | PhosphoserineBy similarity | 1 | |
Modified residuei | 237 | PhosphoserineBy similarity | 1 | |
Modified residuei | 280 | PhosphoserineCombined sources | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 | |
Modified residuei | 285 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9QYW0 |
PaxDbi | Q9QYW0 |
PRIDEi | Q9QYW0 |
PTM databases
iPTMneti | Q9QYW0 |
PhosphoSitePlusi | Q9QYW0 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000002778, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | Q9QYW0, RN |
Interactioni
Subunit structurei
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130 and SP1 (By similarity). Binds DAPK3/ZIPK and TSG101. May also bind MAPT.
By similarityGO - Molecular functioni
- leucine zipper domain binding Source: RGD
- protein kinase binding Source: RGD
- tau protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 250358, 6 interactors |
MINTi | Q9QYW0 |
STRINGi | 10116.ENSRNOP00000000258 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 237 – 279 | Binds POLR2JBy similarityAdd BLAST | 43 | |
Regioni | 280 – 335 | Binds RB1By similarityAdd BLAST | 56 | |
Regioni | 336 – 435 | Binds RB1 and SP1By similarityAdd BLAST | 100 | |
Regioni | 447 – 523 | Binds to TSG101Add BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 168 | Glu-richAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the AATF family.Curated
Phylogenomic databases
eggNOGi | KOG2773, Eukaryota |
GeneTreei | ENSGT00390000000288 |
HOGENOMi | CLU_018299_1_2_1 |
InParanoidi | Q9QYW0 |
OMAi | LINFMAP |
OrthoDBi | 794860at2759 |
PhylomeDBi | Q9QYW0 |
TreeFami | TF324341 |
Family and domain databases
InterProi | View protein in InterPro IPR025160, AATF IPR039223, AATF/Bfr2 IPR012617, AATF_C |
PANTHERi | PTHR15565, PTHR15565, 1 hit |
Pfami | View protein in Pfam PF13339, AATF-Che1, 1 hit PF08164, TRAUB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9QYW0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELQPLALQ LEQLLNPRPR EADPEADPEE ATRARVIDRF DEGEEEEDDL
60 70 80 90 100
PVSSIRKLAP VSLLDTDKRY SGKTTSRKAW KEDHWDQTLP SSSDNEIPDE
110 120 130 140 150
GGSEAGDSEG LEELSEDVEE DLEDNEIPDE GGSEDGDSEG LEEEISEDVE
160 170 180 190 200
EDLEGEDEED REEDRNSEDD GVVMAFSGVK VSEEVEKGRA VKNQIALWDQ
210 220 230 240 250
LLEGRIKLQK ALLTTNQLPQ PDVFPVFKDK GGPEFASALK NSHKALKALL
260 270 280 290 300
RSLVDLQEEL LFQYPDTRYL VKGTKPNAES EEISSEDDEL VGEKKKQRKA
310 320 330 340 350
PPKRKLEMED YPSFMAKRSA DFTVYRNRTL QKWHDKTKLA SGKLGKGFGA
360 370 380 390 400
FERSILTQID HILMDKERLL RRTQTKRSAY RVLGKPEPVP EPVAETLPGE
410 420 430 440 450
PESLPQVPAN AHLKDLDEEI FDDDDFYHQL LRELIERKTS SLDPNDQVAM
460 470 480 490 500
GRQWLAIQKL RSKIRKKVDR KASKGRKLRF HVLSKLLSFM APIDHTAMND
510 520
EARTELYRSL FGQLNRLDAD HGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ238717 mRNA Translation: CAB59426.1 BC078769 mRNA Translation: AAH78769.1 |
RefSeqi | NP_446172.1, NM_053720.1 |
Genome annotation databases
Ensembli | ENSRNOT00000000258; ENSRNOP00000000258; ENSRNOG00000002778 |
GeneIDi | 114512 |
KEGGi | rno:114512 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ238717 mRNA Translation: CAB59426.1 BC078769 mRNA Translation: AAH78769.1 |
RefSeqi | NP_446172.1, NM_053720.1 |
3D structure databases
SMRi | Q9QYW0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250358, 6 interactors |
MINTi | Q9QYW0 |
STRINGi | 10116.ENSRNOP00000000258 |
PTM databases
iPTMneti | Q9QYW0 |
PhosphoSitePlusi | Q9QYW0 |
Proteomic databases
jPOSTi | Q9QYW0 |
PaxDbi | Q9QYW0 |
PRIDEi | Q9QYW0 |
Genome annotation databases
Ensembli | ENSRNOT00000000258; ENSRNOP00000000258; ENSRNOG00000002778 |
GeneIDi | 114512 |
KEGGi | rno:114512 |
Organism-specific databases
CTDi | 26574 |
RGDi | 620685, Aatf |
Phylogenomic databases
eggNOGi | KOG2773, Eukaryota |
GeneTreei | ENSGT00390000000288 |
HOGENOMi | CLU_018299_1_2_1 |
InParanoidi | Q9QYW0 |
OMAi | LINFMAP |
OrthoDBi | 794860at2759 |
PhylomeDBi | Q9QYW0 |
TreeFami | TF324341 |
Miscellaneous databases
PROi | PR:Q9QYW0 |
Gene expression databases
Bgeei | ENSRNOG00000002778, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | Q9QYW0, RN |
Family and domain databases
InterProi | View protein in InterPro IPR025160, AATF IPR039223, AATF/Bfr2 IPR012617, AATF_C |
PANTHERi | PTHR15565, PTHR15565, 1 hit |
Pfami | View protein in Pfam PF13339, AATF-Che1, 1 hit PF08164, TRAUB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AATF_RAT | |
Accessioni | Q9QYW0Primary (citable) accession number: Q9QYW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families