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Entry version 126 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

DNA polymerase subunit gamma-1

Gene

Polg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication
LigandMagnesium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase subunit gamma-1 (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
PolG-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Polg
Synonyms:Mip1, Polg1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
620057 Polg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001012721 – 1216DNA polymerase subunit gamma-1Add BLAST1216

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QYV8

PRoteomics IDEntifications database

More...
PRIDEi
Q9QYV8

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QYV8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000032293 Expressed in 9 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QYV8 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047900

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3657 Eukaryota
COG0749 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000176668

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QYV8

KEGG Orthology (KO)

More...
KOi
K02332

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTEVMWK

Database of Orthologous Groups

More...
OrthoDBi
86850at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QYV8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019760 DNA-dir_DNA_pol_A_CS
IPR002297 DNA-dir_DNA_pol_A_mt
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR041336 DNApol_Exo
IPR012337 RNaseH-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10267 PTHR10267, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00476 DNA_pol_A, 1 hit
PF18136 DNApol_Exo, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000797 DNA_pol_mt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00867 DNAPOLG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00482 POLAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9QYV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLLWKKVA GAKVASGPVP ATGRWVSSSV LDPVPSDGQP QSQMPSSENG
60 70 80 90 100
QLRLNPLHIQ MLSRGLHEQI FGCGGDVPDE AAVQRSIEHL RKHGLWGQPT
110 120 130 140 150
TPLPDVQLRL PRLFGGNLDQ HFRLLAQKQS LPYLEAAASL SEAQLPPQPR
160 170 180 190 200
KWVWAEGWTR YGPEGEAEPV AIPEERALVF DVEVCLAEGT CPTLAVAISP
210 220 230 240 250
SAWYSWCSRR LVEERYSWTS QLSPADLIPL GVSASASSST QQDWQEQLVV
260 270 280 290 300
GHNVSFDRAH IREQYLIQGS RMRFLDTMSM HMAISGLSSF QRSLWMGAKQ
310 320 330 340 350
GKHKTQHPTK RGQKSQKNAN GPAISSWDWM DISSANNLAD VHNLYVGGPR
360 370 380 390 400
LAKEPRELFV KGSMRDIREN FQDLMEYCAR DVWATFEVFQ QQLPLFLERC
410 420 430 440 450
PHPVTLAGML EMGVSYLPVN QNWERYLTEA QSTYEELQRE MKKSLMELAN
460 470 480 490 500
DACQLLSGER YKEDPWLWDL EWDLQEFKQK KAKKVKKTAS ASKLPIEGAG
510 520 530 540 550
PFGDPMDQED PGPPSEEEEL QQNIMAHTRL QQLKSTTDLL PKRPQHLPGH
560 570 580 590 600
PGWYRKLCPR LDDPAWTPGP SLLSLQMRVT PKLMALTWDG FPLHYSDSHG
610 620 630 640 650
WGYLVPGRRD NLTELPVSPT EESAAVTCPY RAIESLYRRH CLDQGKQQLE
660 670 680 690 700
TQETDLAEEF LLTDSAMWQT VEELGCLDVE AEATVESSGL SQPLVPPTAC
710 720 730 740 750
APKTSQPTYH HGNGPYNDVD IPGCWFFKLP HKDGNNYNVG SPFAKDFLPK
760 770 780 790 800
MEDGTLQAGP GGARGPRALE INKMISFWRN AHKRISSQMV VWLPRSALPR
810 820 830 840 850
AVTRHPSFDE ESHYGAILPQ VVTAGTITRR AVEPTWLTAS NARPDRVGSE
860 870 880 890 900
LKAMVQAPPG YVLVGADVDS QELWIAAVLG DAHFAGMHGC TAFGWMTLQG
910 920 930 940 950
RKSRGTDLHS KTAATVGISR EHAKVFNYGR IYGAGQSFAE RLLMQFNHRL
960 970 980 990 1000
SRQEAADKAQ QMYAVTKGLR RYRLSDDGEW LVKQLNVPVD RTEDGWVSLQ
1010 1020 1030 1040 1050
DLRKIRREAS RKSRWKKWEV VTERAWTGGT ESEMFNKLES IAMSDTPRTP
1060 1070 1080 1090 1100
VLGCCISRAL EPSVVQGEFM TSRVNWVVQS SAVDYLHLML VAMKWLFEEF
1110 1120 1130 1140 1150
AIDGRFCISI HDEVRYLVRE EDRYRAALAL QITNLLTRCM FAYKLGLNDL
1160 1170 1180 1190 1200
PQSVAFFSAV DIDQCLRKEV TMDCKTPSNP TGMERKYGIP QGEALDIYQI
1210
IELTKGSLEK RSQPGP
Length:1,216
Mass (Da):136,856
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA74CD68B6BDB690C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti273R → H in Novikoff hepatoma cells. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ245646 mRNA Translation: CAB56206.1
AJ245647 mRNA Translation: CAB56207.1

NCBI Reference Sequences

More...
RefSeqi
NP_445980.1, NM_053528.1
XP_006229472.1, XM_006229410.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000044567; ENSRNOP00000047900; ENSRNOG00000032293

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85472

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:85472

UCSC genome browser

More...
UCSCi
RGD:620057 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245646 mRNA Translation: CAB56206.1
AJ245647 mRNA Translation: CAB56207.1
RefSeqiNP_445980.1, NM_053528.1
XP_006229472.1, XM_006229410.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047900

PTM databases

PhosphoSitePlusiQ9QYV8

Proteomic databases

PaxDbiQ9QYV8
PRIDEiQ9QYV8

Genome annotation databases

EnsembliENSRNOT00000044567; ENSRNOP00000047900; ENSRNOG00000032293
GeneIDi85472
KEGGirno:85472
UCSCiRGD:620057 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5428
RGDi620057 Polg

Phylogenomic databases

eggNOGiKOG3657 Eukaryota
COG0749 LUCA
GeneTreeiENSGT00390000000453
HOGENOMiHOG000176668
InParanoidiQ9QYV8
KOiK02332
OMAiDTEVMWK
OrthoDBi86850at2759
PhylomeDBiQ9QYV8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9QYV8

Gene expression databases

BgeeiENSRNOG00000032293 Expressed in 9 organ(s), highest expression level in liver
GenevisibleiQ9QYV8 RN

Family and domain databases

InterProiView protein in InterPro
IPR019760 DNA-dir_DNA_pol_A_CS
IPR002297 DNA-dir_DNA_pol_A_mt
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR041336 DNApol_Exo
IPR012337 RNaseH-like_sf
PANTHERiPTHR10267 PTHR10267, 1 hit
PfamiView protein in Pfam
PF00476 DNA_pol_A, 1 hit
PF18136 DNApol_Exo, 1 hit
PIRSFiPIRSF000797 DNA_pol_mt, 1 hit
PRINTSiPR00867 DNAPOLG
SMARTiView protein in SMART
SM00482 POLAc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOG1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QYV8
Secondary accession number(s): Q9QYV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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