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Protein

Potassium voltage-gated channel subfamily G member 2

Gene

Kcng2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-1296072 Voltage gated Potassium channels
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 2
Alternative name(s):
Cardiac potassium channel subunit
Voltage-gated potassium channel subunit Kv6.2
Gene namesi
Name:Kcng2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1309521 Kcng2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 190CytoplasmicSequence analysisAdd BLAST190
Transmembranei191 – 211Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei231 – 251Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini252 – 265CytoplasmicSequence analysisAdd BLAST14
Transmembranei266 – 286Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei301 – 321Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini322 – 334CytoplasmicSequence analysisAdd BLAST13
Transmembranei335 – 355Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei370 – 390Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei398 – 418Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini419 – 480CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540751 – 480Potassium voltage-gated channel subfamily G member 2Add BLAST480

Proteomic databases

PaxDbiQ9QYU3
PRIDEiQ9QYU3

PTM databases

iPTMnetiQ9QYU3
PhosphoSitePlusiQ9QYU3

Expressioni

Tissue specificityi

Highly expressed in heart, in particular in right and left atrium, and detected at lower levels in the right and left ventricle.

Gene expression databases

BgeeiENSRNOG00000053640 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiQ9QYU3 RN

Interactioni

Subunit structurei

Heterodimer with KCNB1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023089

Structurei

3D structure databases

ProteinModelPortaliQ9QYU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi382 – 387Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231014
HOVERGENiHBG100172
InParanoidiQ9QYU3
KOiK04901
OMAiIINVGGC
OrthoDBiEOG091G0DSU
PhylomeDBiQ9QYU3

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003969 K_chnl_volt-dep_Kv6
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01492 KV6CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QYU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLPGHPEV PGAEPGSAVR GGRGGRGARA RHVIINVGGC RVRLAWAALA
60 70 80 90 100
RCPLARLERL RACRGHDELL RVCDDYDVSR DEFFFDRSPC AFRAIVALLR
110 120 130 140 150
AGKLRLLRGP CALAFRDELA YWGIDEARLE RCCLRRLRRR EEEAAEARAT
160 170 180 190 200
PPARGPQTSP GRALGSGRLE RGRRRLRDVV ENPHSGLAGK LFAYVSVAFV
210 220 230 240 250
AVTAVGLCLS TMPDVRAEEE RGECSTKCRN LFVLETVCVA WFSFEFLLRS
260 270 280 290 300
LQAESKCAFL RTPLAIIDIL AILPFYVSLL AGLAAGPTGS KMLERAGLVL
310 320 330 340 350
RLLRALRVLY VMRLARHSLG LRSLGLTVRR CAREFGLLLL FLCVAMALFA
360 370 380 390 400
PLVHLAEREL GAHRDFSSVP ASYWWAVISM TTVGYGDMVP RSLPGQVVAL
410 420 430 440 450
SSILSGILLM AFPVTSIFHT FSRSYSELKE QQQRAASPEP VLREDSTRDD
460 470 480
STRSASATED SSQDPETAGA AGSLPGPVGP
Length:480
Mass (Da):52,536
Last modified:May 1, 2000 - v1
Checksum:i601C86531B01F6FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011020 mRNA Translation: CAB56852.1
RefSeqiNP_001100842.1, NM_001107372.1
XP_006255009.1, XM_006254947.2
XP_006255010.1, XM_006254948.3
XP_006255012.1, XM_006254950.3
XP_008770358.1, XM_008772136.2
XP_008770359.1, XM_008772137.2
XP_017456433.1, XM_017600944.1
UniGeneiRn.163389

Genome annotation databases

EnsembliENSRNOT00000088054; ENSRNOP00000069556; ENSRNOG00000053640
GeneIDi307234
KEGGirno:307234

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011020 mRNA Translation: CAB56852.1
RefSeqiNP_001100842.1, NM_001107372.1
XP_006255009.1, XM_006254947.2
XP_006255010.1, XM_006254948.3
XP_006255012.1, XM_006254950.3
XP_008770358.1, XM_008772136.2
XP_008770359.1, XM_008772137.2
XP_017456433.1, XM_017600944.1
UniGeneiRn.163389

3D structure databases

ProteinModelPortaliQ9QYU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023089

PTM databases

iPTMnetiQ9QYU3
PhosphoSitePlusiQ9QYU3

Proteomic databases

PaxDbiQ9QYU3
PRIDEiQ9QYU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000088054; ENSRNOP00000069556; ENSRNOG00000053640
GeneIDi307234
KEGGirno:307234

Organism-specific databases

CTDi26251
RGDi1309521 Kcng2

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231014
HOVERGENiHBG100172
InParanoidiQ9QYU3
KOiK04901
OMAiIINVGGC
OrthoDBiEOG091G0DSU
PhylomeDBiQ9QYU3

Enzyme and pathway databases

ReactomeiR-RNO-1296072 Voltage gated Potassium channels
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Miscellaneous databases

PROiPR:Q9QYU3

Gene expression databases

BgeeiENSRNOG00000053640 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiQ9QYU3 RN

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003969 K_chnl_volt-dep_Kv6
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01492 KV6CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNG2_RAT
AccessioniPrimary (citable) accession number: Q9QYU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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