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Protein

Protein Wnt-16

Gene

Wnt16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-16
Gene namesi
Name:Wnt16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136018 Wnt16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004147230 – 364Protein Wnt-16Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 92By similarity
Disulfide bondi138 ↔ 146By similarity
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 167By similarity
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 234By similarity
Disulfide bondi222 ↔ 229By similarity
Lipidationi226O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi309 ↔ 324By similarity
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ9QYS1
PRIDEiQ9QYS1

PTM databases

PhosphoSitePlusiQ9QYS1

Expressioni

Gene expression databases

BgeeiENSMUSG00000029671 Expressed in 111 organ(s), highest expression level in kidney interstitium
CleanExiMM_WNT16
ExpressionAtlasiQ9QYS1 baseline and differential
GenevisibleiQ9QYS1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031681

Structurei

3D structure databases

ProteinModelPortaliQ9QYS1
SMRiQ9QYS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ9QYS1
KOiK01558
OMAiFIWCCYV
OrthoDBiEOG091G0OFF
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013304 Wnt16
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01895 WNT16PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9QYS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRAALLALP SLCALWAAVL SLLPCGTQGN WMWLGIASFG VPEKLGCADL
60 70 80 90 100
PLNSRQKELC KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST
110 120 130 140 150
QLATAPLFGY ELSSGTKETA FIYAIMAAGL VHSVTRSCSA GNMTECSCDT
160 170 180 190 200
TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK FLDLPIRNTT GKESRVLLAM
210 220 230 240 250
NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS FEKIGHFLKD
260 270 280 290 300
KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG
310 320 330 340 350
IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR
360
CRRCESMTDV HTCK
Length:364
Mass (Da):40,727
Last modified:July 27, 2011 - v2
Checksum:i68A71C82DDE2D3A2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BRT3Q8BRT3_MOUSE
Protein Wnt
Wnt16
225Annotation score:
H3BJ29H3BJ29_MOUSE
Protein Wnt
Wnt16
225Annotation score:
H3BL02H3BL02_MOUSE
Protein Wnt
Wnt16
76Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265K → N in AAD49352 (PubMed:10500199).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172064, AF169964 Genomic DNA Translation: AAD49352.2
CH466533 Genomic DNA Translation: EDL13846.1
BC115811 mRNA Translation: AAI15812.1
BC115925 mRNA Translation: AAI15926.1
CCDSiCCDS19936.1
RefSeqiNP_444346.3, NM_053116.4
UniGeneiMm.137403

Genome annotation databases

EnsembliENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671
GeneIDi93735
KEGGimmu:93735
UCSCiuc009bax.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172064, AF169964 Genomic DNA Translation: AAD49352.2
CH466533 Genomic DNA Translation: EDL13846.1
BC115811 mRNA Translation: AAI15812.1
BC115925 mRNA Translation: AAI15926.1
CCDSiCCDS19936.1
RefSeqiNP_444346.3, NM_053116.4
UniGeneiMm.137403

3D structure databases

ProteinModelPortaliQ9QYS1
SMRiQ9QYS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031681

PTM databases

PhosphoSitePlusiQ9QYS1

Proteomic databases

PaxDbiQ9QYS1
PRIDEiQ9QYS1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031681; ENSMUSP00000031681; ENSMUSG00000029671
GeneIDi93735
KEGGimmu:93735
UCSCiuc009bax.2 mouse

Organism-specific databases

CTDi51384
MGIiMGI:2136018 Wnt16

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ9QYS1
KOiK01558
OMAiFIWCCYV
OrthoDBiEOG091G0OFF
TreeFamiTF105310

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Miscellaneous databases

PROiPR:Q9QYS1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029671 Expressed in 111 organ(s), highest expression level in kidney interstitium
CleanExiMM_WNT16
ExpressionAtlasiQ9QYS1 baseline and differential
GenevisibleiQ9QYS1 MM

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013304 Wnt16
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01895 WNT16PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT16_MOUSE
AccessioniPrimary (citable) accession number: Q9QYS1
Secondary accession number(s): Q14BF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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