Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 152 (18 Sep 2019)
Sequence version 2 (09 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Microtubule-associated protein 1A

Gene

Map1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 1A
Short name:
MAP-1A
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map1a
Synonyms:Mtap1, Mtap1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1306776 Map1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727531 – 2776Microtubule-associated protein 1AAdd BLAST2776
ChainiPRO_00004183771 – 2542MAP1A heavy chainAdd BLAST2542
ChainiPRO_00002697272543 – 2776MAP1 light chain LC2Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei177PhosphotyrosineCombined sources1
Modified residuei319PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei384PhosphoserineCombined sources1
Modified residuei504PhosphothreonineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei604PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei633PhosphothreonineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei786PhosphoserineBy similarity1
Modified residuei873PhosphoserineCombined sources1
Modified residuei876PhosphoserineCombined sources1
Modified residuei877PhosphoserineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei893PhosphothreonineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei899PhosphoserineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei981PhosphoserineCombined sources1
Modified residuei991PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1008PhosphoserineCombined sources1
Modified residuei1014PhosphoserineBy similarity1
Modified residuei1023PhosphoserineCombined sources1
Modified residuei1062PhosphoserineCombined sources1
Modified residuei1068PhosphothreonineCombined sources1
Modified residuei1131PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1159PhosphoserineBy similarity1
Modified residuei1177PhosphoserineCombined sources1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1190PhosphoserineBy similarity1
Modified residuei1196PhosphoserineCombined sources1
Modified residuei1205PhosphoserineCombined sources1
Modified residuei1208PhosphoserineBy similarity1
Modified residuei1251PhosphoserineBy similarity1
Modified residuei1289PhosphoserineCombined sources1
Modified residuei1310PhosphoserineCombined sources1
Modified residuei1313PhosphoserineCombined sources1
Modified residuei1316PhosphoserineCombined sources1
Modified residuei1516PhosphoserineCombined sources1
Modified residuei1580PhosphoserineBy similarity1
Modified residuei1606PhosphoserineCombined sources1
Modified residuei1634PhosphoserineBy similarity1
Modified residuei1648PhosphoserineBy similarity1
Modified residuei1720PhosphoserineBy similarity1
Modified residuei1747PhosphoserineCombined sources1
Modified residuei1762PhosphoserineCombined sources1
Modified residuei1768PhosphoserineCombined sources1
Modified residuei1772PhosphoserineCombined sources1
Modified residuei1777PhosphothreonineCombined sources1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1789PhosphoserineCombined sources1
Modified residuei1902PhosphoserineBy similarity1
Modified residuei1928PhosphothreonineBy similarity1
Modified residuei1993PhosphoserineBy similarity1
Modified residuei2031PhosphothreonineBy similarity1
Modified residuei2048PhosphoserineBy similarity1
Modified residuei2082PhosphoserineCombined sources1
Modified residuei2209PhosphoserineBy similarity1
Modified residuei2226PhosphoserineBy similarity1
Modified residuei2230PhosphoserineBy similarity1
Modified residuei2233PhosphoserineBy similarity1
Modified residuei2234PhosphoserineBy similarity1
Modified residuei2425PhosphoserineBy similarity1
Modified residuei2623PhosphoserineBy similarity1
Modified residuei2637PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CSNK1D.By similarity
LC2 is generated from MAP1A by proteolytic processing. It is free to associate with both MAP1A and MAP1B (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9QYR6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QYR6

PRoteomics IDEntifications database

More...
PRIDEi
Q9QYR6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QYR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QYR6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9QYR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Both isoforms highly expressed in brain, and to a lesser extent in embryo. Isoform 1 is also expressed at a low level in other tissues including heart and muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027254 Expressed in 214 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9QYR6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QYR6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.

Interacts with guanylate kinase-like domain of DLG1, DLG2 and DLG4. Binds to CSNK1D (By similarity).

Interacts with TIAM2. MAP1 light chain LC2:

Interacts with ELAVL4 (PubMed:21288476).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201583, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q9QYR6, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9QYR6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000092223

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12776
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QYR6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati336 – 33813
Repeati415 – 41723
Repeati420 – 42233
Repeati424 – 42643
Repeati427 – 42953
Repeati431 – 43363
Repeati436 – 43873
Repeati440 – 44283
Repeati444 – 44693
Repeati449 – 451103
Repeati539 – 541113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni336 – 54111 X 3 AA approximate repeats of K-K-[DE]Add BLAST206

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi338 – 677Glu-richAdd BLAST340
Compositional biasi1748 – 2303Pro-richAdd BLAST556
Compositional biasi2530 – 2551Pro-richAdd BLAST22
Compositional biasi2747 – 2750Poly-Gln4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3592 Eukaryota
ENOG410XRYM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158701

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QYR6

KEGG Orthology (KO)

More...
KOi
K10429

Database of Orthologous Groups

More...
OrthoDBi
86642at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026074 MAP1
IPR015656 MAP1A
IPR036866 RibonucZ/Hydroxyglut_hydro

The PANTHER Classification System

More...
PANTHERi
PTHR13843 PTHR13843, 1 hit
PTHR13843:SF6 PTHR13843:SF6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56281 SSF56281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QYR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS
60 70 80 90 100
ALFAVNGFNI LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING
110 120 130 140 150
LLQRKVAELE EEQSQGSSSY SDWVKNLISP ELGVVFFNVP DKLRLPDASR
160 170 180 190 200
KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV SNTIEPLTLF HKMGVGRLDM
210 220 230 240 250
YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LANGKEAEIS VPYLTSITAL
260 270 280 290 300
VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA
310 320 330 340 350
AGAVPANLKP SKIKHRADSK ESLKAAPKTA MSKLAKREEV LEEGAKEARS
360 370 380 390 400
ELAKELAKSE KKAKEPSEKP PEKPSKPERV RTESSEALKA EKRKLIKDKV
410 420 430 440 450
GKKHLKEKIS KLEEKRDKEK KEIKKERKEL KKEEGRKEEK KDAKKDEKRK
460 470 480 490 500
DTKPELKKFS KPDLKPFTPE VRKTLYKAKA PGRLKVDKGR AARGEKELSS
510 520 530 540 550
EPRTPPAQKG AAPPPAASGH RELALSSPED LTQDFEELKR EERGLLAEPR
560 570 580 590 600
DTELGEKPLP ADASEQGRPS TAIQVTQPPA SVLEQEQVER EKEVVPDFPE
610 620 630 640 650
DKGSKNRAPD SGAEVEREKE TWEERKPREA ELTPENIAAA REESEPEVKE
660 670 680 690 700
DVIEKAELEE MEEVHPSDEE EEETKAESFY QKHMQEALKV IPKGREALGG
710 720 730 740 750
RELGFQGKAP EKETASFLSS LATPAGAAEH VSYIQDETIP GYSETEQTIS
760 770 780 790 800
DEEIHDEPDE RPAPPRFPTS TYDLSGPEGP GPFEASQSAE SAVPASSSKT
810 820 830 840 850
YGAPETELTY PPNMVAAPLA EEEHVSSATS ITECDKLSSF ATSVAEDQSV
860 870 880 890 900
ASLTAPQTEE TGKSSLLLDT VTSIPSSRTE ATQGLDYVPS AGTISPTSSL
910 920 930 940 950
EEDKGFKSPP CEDFSVTGES EKKGESVGRG LTGEKAVGKE EKNVTTSEKL
960 970 980 990 1000
SSQYAAVFGA PGHALHPGEP ALGEVEERCL SPDDSTVKMA SPPPSGPPSA
1010 1020 1030 1040 1050
AHTPFHQSPV EEKSEPQDFQ EDSWGDTKHA PGVSKEDAEE QTVKPGPEEA
1060 1070 1080 1090 1100
MSEEGKVPLS RSPQAQDTLG SLAGGQTGCT IQLLPEQDKA VVFETGEAGA
1110 1120 1130 1140 1150
ASGAGSLPGE VRTQEPAEPQ KDELLGFTDQ SFSPEDAESL SVLSVVSPDT
1160 1170 1180 1190 1200
AKQEATPRSP CTPKEQQLHK DLWPMVSPED TQSLSFSEES PSKETSLDIS
1210 1220 1230 1240 1250
SKQLSPESLG TLQFGELSLG KEEKGPLVKA EDNSCHLAPV SIPEPHTATV
1260 1270 1280 1290 1300
SPPTDEAAGE AGLTDESPAG NLPGSSFSHS ALSGDRKHSP GEITGPGGHF
1310 1320 1330 1340 1350
MTSDSSLTKS PESLSSPAME DLAMEWGGKA PGSEDRATEQ KEKELERKSE
1360 1370 1380 1390 1400
TLQQKDQILS EKAALVQRDS VMHQKDEALD EENKPGGQQD KTSEQKGRDL
1410 1420 1430 1440 1450
DKKDTAVELG KGPEPKGKDL YLEDQGLAEK DKALEQRGAA LQQTQAPEPR
1460 1470 1480 1490 1500
ARAQEHRDLE QKDEHLELRD KTPEEKDKVL VLEDRAPEHI IPQPTQTDRA
1510 1520 1530 1540 1550
PEHRSKVDKE QKDEASEEKE QVLEQKDWAR EKEGAALDQD NRAAGQKDGT
1560 1570 1580 1590 1600
LKEDKTQGQK SSFLEDKSTT PKEMTLDQKS PEKAKGVEQQ DGAVPEKTRA
1610 1620 1630 1640 1650
LGLEESPEEE GKAREQEEKY WKEQDVVQGW RETSPTRGEP VPAWEGKSPE
1660 1670 1680 1690 1700
QEVRYWRDRD ITLQQDAYWK ELSCERKVWF PHELDGQGAR PRYSEEREST
1710 1720 1730 1740 1750
FLDEGPNEQE ITPLQHTPRS PWASDFKDFQ EPLPQKGLEV ERWLAESPVG
1760 1770 1780 1790 1800
LPPEEEDKLT RSPFEIISPP ASPPEMTGQR VPSAPGQESP VPDTKSTPPT
1810 1820 1830 1840 1850
RNEPTTPSWL AEIPPWVPKD RPLPPAPLSP APAPPTPAPD PHAPAPFSWG
1860 1870 1880 1890 1900
IAEYDSVVAA VQEGAAELEG GPYSPLGKDY RKAEGEREGE GGAGAPDSSS
1910 1920 1930 1940 1950
FSSKVPEVTE SHTTRDAEQT EPEQREPTPY PDERSFQYAD IYEQMMLTGL
1960 1970 1980 1990 2000
GPACPTREPP LGASGDWPPH LSTKEEAAGR NKSAEKELSS AVSPPNLHSD
2010 2020 2030 2040 2050
TPTFSYASLA GPTIPPRQEP EPGPNVEPSF TPPAVPPRAP ISLSQDPSPP
2060 2070 2080 2090 2100
LNGSTTSCGP DRRTPSPKEA GRSHWDDGTN DSDLEKGARE QPEKETQSPS
2110 2120 2130 2140 2150
PHHPMPVGHP SLWPETEAHS SLSSDSHLGP VRPSLDFPAS AFGFSSLQPA
2160 2170 2180 2190 2200
PPQLPSPAEP RSAPCGSLAF SGDRALALVP GTPTRTRHDE YLEVTKAPSL
2210 2220 2230 2240 2250
DSSLPQLPSP SSPGAPLLSN LPRPASPALS EGSSSEATTP VISSVAERFP
2260 2270 2280 2290 2300
PGLEVAEQSS GELGPGNEPA AHSLWDLTPL SPAPLASRDL APAPAPAPAP
2310 2320 2330 2340 2350
SLPGNLGDGT LSCRPECSGE LTKKPSPFLS HSGDHEANGP GETSLNPPGF
2360 2370 2380 2390 2400
ATATAEKEEA EALHAWERGS WPEGAERSSR PDTLLSSEQR PGKSSGGPPC
2410 2420 2430 2440 2450
SLSSEVEAGP QGCATDPRPH CGELSPSFLN PPLPPSTDDS DLSTEEARLA
2460 2470 2480 2490 2500
GKGGRRRAGR PGATGGPCPM ADETPPTSAS DSGSSQSDSD VPPETEECPS
2510 2520 2530 2540 2550
ITAEAALDSD EDGDFLPVDK AGGVSGTHHP RPGHDPPPAP LPDPRPPPPR
2560 2570 2580 2590 2600
PDVCMADPEG LSSESGRVER LREKVQGRPG RKAPGRAKPA SPARRLDIRG
2610 2620 2630 2640 2650
KRSPTPGKGP VDRTSRALPR PRSTPSQVTS EEKDGHSPMS KGLVNGLKAG
2660 2670 2680 2690 2700
STALGSKGSS GPPVYVDLAY IPNHCSGKTA DQDFFRRVRA SYYVVSGNDP
2710 2720 2730 2740 2750
ANGEPSRAVL DALLEGKAQW GENLQVTLIP THDTEVTREW YQQTHEQQQQ
2760 2770
LNVLVLASSS TVVMQDESFP ACKIEF
Length:2,776
Mass (Da):300,140
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62A8CC584CCAB21A
GO
Isoform 2 (identifier: Q9QYR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → METTPELGLQ...LNPEPVLPTM

Show »
Length:3,000
Mass (Da):324,586
Checksum:i58EB524496EB49C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ARP8A2ARP8_MOUSE
Microtubule-associated protein 1A
Map1a Mtap1a
3,014Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti349R → C in BAE27940 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0032011M → METTPELGLQSLGAPPAQNP AEPLCEAGAAVAAARWDLRK YSLLIVIGDIGTESQLRAVR AHLEQGILSWNIDLSSFDLN QQLRLFITRHLAHFSSEVKG QRTLCHQSETLETIILVNPT ADSISSEVHHLLSSPSAHKL LILSGQTLEPEGDLILQSGT YSYQNFAQVLHKPEIAQLLS NRDPGIQAFLTVSCLGEGDW SHLGLSSSQETLHLRLNPEP VLPTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK147474 mRNA Translation: BAE27940.1
AK160546 mRNA Translation: BAE35863.1
AK163468 mRNA Translation: BAE37354.1
AL845466 Genomic DNA No translation available.
AF182211, AF182208, AF182209 Genomic DNA Translation: AAF06164.1
AF182211 Genomic DNA Translation: AAF06163.1
AF182213 mRNA Translation: AAD55790.1
AF182212 mRNA Translation: AAD55789.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50685.1 [Q9QYR6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001166977.1, NM_001173506.1 [Q9QYR6-1]
NP_115769.1, NM_032393.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110639; ENSMUSP00000106269; ENSMUSG00000027254 [Q9QYR6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17754

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17754

UCSC genome browser

More...
UCSCi
uc008lyj.2 mouse [Q9QYR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147474 mRNA Translation: BAE27940.1
AK160546 mRNA Translation: BAE35863.1
AK163468 mRNA Translation: BAE37354.1
AL845466 Genomic DNA No translation available.
AF182211, AF182208, AF182209 Genomic DNA Translation: AAF06164.1
AF182211 Genomic DNA Translation: AAF06163.1
AF182213 mRNA Translation: AAD55790.1
AF182212 mRNA Translation: AAD55789.1
CCDSiCCDS50685.1 [Q9QYR6-1]
RefSeqiNP_001166977.1, NM_001173506.1 [Q9QYR6-1]
NP_115769.1, NM_032393.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GNVX-ray2.60B1866-1891[»]
SMRiQ9QYR6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201583, 10 interactors
IntActiQ9QYR6, 6 interactors
MINTiQ9QYR6
STRINGi10090.ENSMUSP00000092223

PTM databases

iPTMnetiQ9QYR6
PhosphoSitePlusiQ9QYR6
SwissPalmiQ9QYR6

Proteomic databases

jPOSTiQ9QYR6
PaxDbiQ9QYR6
PRIDEiQ9QYR6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110639; ENSMUSP00000106269; ENSMUSG00000027254 [Q9QYR6-1]
GeneIDi17754
KEGGimmu:17754
UCSCiuc008lyj.2 mouse [Q9QYR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4130
MGIiMGI:1306776 Map1a

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00940000158701
InParanoidiQ9QYR6
KOiK10429
OrthoDBi86642at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9QYR6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027254 Expressed in 214 organ(s), highest expression level in brain
ExpressionAtlasiQ9QYR6 baseline and differential
GenevisibleiQ9QYR6 MM

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR015656 MAP1A
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR13843 PTHR13843, 1 hit
PTHR13843:SF6 PTHR13843:SF6, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP1A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QYR6
Secondary accession number(s): A2ARN9
, Q3TQM8, Q3TUV8, Q3UHB7, Q9QZH9, Q9QZI0, Q9QZI1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 9, 2007
Last modified: September 18, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again