Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (05 Jun 2019)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

Celsr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2Curated
Alternative name(s):
Multiple epidermal growth factor-like domains protein 3
Short name:
Multiple EGF-like domains protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celsr2Imported
Synonyms:Megf3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
69237 Celsr2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 1605ExtracellularSequence analysisAdd BLAST1605
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1606 – 1626Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini1627 – 1641CytoplasmicSequence analysisAdd BLAST15
Transmembranei1642 – 1662Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini1663ExtracellularSequence analysis1
Transmembranei1664 – 1684Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1685 – 1705CytoplasmicSequence analysisAdd BLAST21
Transmembranei1706 – 1726Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1727 – 1744ExtracellularSequence analysisAdd BLAST18
Transmembranei1745 – 1765Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1766 – 1789CytoplasmicSequence analysisAdd BLAST24
Transmembranei1790 – 1810Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1811 – 1816ExtracellularSequence analysis6
Transmembranei1817 – 1837Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1838 – 2144CytoplasmicSequence analysisAdd BLAST307

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000070345‹1 – 2144Cadherin EGF LAG seven-pass G-type receptor 2Add BLAST›2144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi457 ↔ 468By similarity
Disulfide bondi462 ↔ 499By similarity
Disulfide bondi501 ↔ 510By similarity
Disulfide bondi517 ↔ 528By similarity
Disulfide bondi522 ↔ 537By similarity
Disulfide bondi539 ↔ 548By similarity
Disulfide bondi557 ↔ 568By similarity
Disulfide bondi562 ↔ 578By similarity
Disulfide bondi580 ↔ 590By similarity
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi770 ↔ 796By similarity
Glycosylationi790N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi803 ↔ 814By similarity
Disulfide bondi808 ↔ 823By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei816(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi825 ↔ 834By similarity
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi986 ↔ 1016By similarity
Disulfide bondi1022 ↔ 1033By similarity
Disulfide bondi1027 ↔ 1042By similarity
Modified residuei1035(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi1044 ↔ 1053By similarity
Glycosylationi1052N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1057 ↔ 1068By similarity
Disulfide bondi1062 ↔ 1080By similarity
Disulfide bondi1082 ↔ 1091By similarity
Disulfide bondi1112 ↔ 1124By similarity
Disulfide bondi1114 ↔ 1131By similarity
Glycosylationi1125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1133 ↔ 1146By similarity
Disulfide bondi1149 ↔ 1161By similarity
Disulfide bondi1151 ↔ 1168By similarity
Disulfide bondi1170 ↔ 1179By similarity
Disulfide bondi1182 ↔ 1194By similarity
Glycosylationi1249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1570N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9QYP2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QYP2

PRoteomics IDEntifications database

More...
PRIDEi
Q9QYP2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QYP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QYP2

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q9QYP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain. High expression in cerebellum and olfactory bulb. Weaker expression in cerebral cortex, hippocampus and brain stem.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000027263

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QYP2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 40Cadherin 1PROSITE-ProRule annotationAdd BLAST›40
Domaini41 – 146Cadherin 2PROSITE-ProRule annotationAdd BLAST106
Domaini147 – 248Cadherin 3PROSITE-ProRule annotationAdd BLAST102
Domaini253 – 371Cadherin 4PROSITE-ProRule annotationAdd BLAST119
Domaini453 – 511EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini513 – 549EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini553 – 591EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini592 – 796Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini799 – 835EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini839 – 1016Laminin G-like 2PROSITE-ProRule annotationAdd BLAST178
Domaini1018 – 1053EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1054 – 1092EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1108 – 1147EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1149 – 1196Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini1541 – 1593GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1968 – 1973Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4289 Eukaryota
ENOG410XTGH LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231346

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QYP2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QYP2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 2 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 3 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 4 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QYP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EDQVSYTLAI TARDNGIPQK SDTTYLEILV NDVNDNAPQF LRDSYQGSVY
60 70 80 90 100
EDVPPFTSVL QISATDRDSG LNGRVFYTFQ GGDDGDGDFI VESTSGIVRT
110 120 130 140 150
LRRLDRENVA QYILRAYAVD KGMPPARTPM EVTVTVLDVN DNPPVFEQDE
160 170 180 190 200
FDVFVEENSP IGLAVARVTA TDPDEGTNAQ IMYQIVEGNI PEVFQLDIFS
210 220 230 240 250
GELTALVDLD YEDRPEYILV IQATSAPLVS RATVHVRLLD RNDNPPVLGN
260 270 280 290 300
FEILFNNYVT NRSSSFPGGA IGRVPAHDPD ISDSLTYSFE RGNELSLVLL
310 320 330 340 350
NASTGELRLS RALDNNRPLE AIMSVLVSDG VHSVTAQCSL RVTIITDEML
360 370 380 390 400
THSITLRLED MSPERFLSPL LGLFIQAVAA TLATPPDHVV VFNVQRDTDA
410 420 430 440 450
PGGHILNVSL SVGQPPGPGG GPPFLPSEDL QERLYLNRSL LTAISAQRVL
460 470 480 490 500
PFDDNICLRE PCENYMRCVS VLRFDSSAPF IASSSVLFRP IHPVGGLRCR
510 520 530 540 550
CPPGFTGDYC ETEVDLCYSR PCGPHGHCRS REGGYTCLCR DGYTGEHCEV
560 570 580 590 600
SARSGRCTPG VCKNGGTCVN LLVGGFKCDC PSGDFEKPFC QVTTRSFPAR
610 620 630 640 650
SFITFRGLRQ RFHFTLALSF ATKERDGLLL YNGRFNEKHD FVALEVIQEQ
660 670 680 690 700
VQLTFSAGES TTTVSPFVPG GVSDGQWHTV QLKYYNKPLL GQTGLPQGPS
710 720 730 740 750
EQKVAVVSVD GCDTGVALRF GAMLGNYSCA AQGTQGGSKK SLDLTGPLLL
760 770 780 790 800
GGVPDLPESF PVRMRHFVGC MKNLQVDSRH VDMADFIANN GTVPGCPTKK
810 820 830 840 850
NVCDSNTCHN GGTCVNQWDA FSCECPLGFG GKSCAQEMAN PQRFLGSSLV
860 870 880 890 900
AWHGLSLPIS QPWHLSLMFR TRQADGVLLQ AVTRGRSTIT LQLRAGHVVL
910 920 930 940 950
SVEGTGLQAS SLRLEPGRAN DGDWHHAQLS LGASGGPGHA ILSFDYGQQK
960 970 980 990 1000
AEGNLGPRLH GLHLSNMTVG GVPGPASSVA RGFRGCLQGV RVSETPEGVS
1010 1020 1030 1040 1050
SLDPSRGESI NVEPGCSWPD PCDSNPCPTN SYCSNDWDSY SCSCDPGYYG
1060 1070 1080 1090 1100
DNCTNVCDLN PCEHQSACTR KPSAPHGYIC ECLPNYLGPY CETRIDQPCP
1110 1120 1130 1140 1150
RGWWGHPTCG PCNCDVSKGF DPDCNKTSGE CHCKENHYRP PSSPTCLLCD
1160 1170 1180 1190 1200
CYPTGSLSRV CDPEDGQCPC KPGVIGRQCD RCDNPFAEVT TNGCEVNYDS
1210 1220 1230 1240 1250
CPRAIEAGIW WPRTRFGLPA AAPCPKGSFG TAVRHCDEHR GWLPPNLFNC
1260 1270 1280 1290 1300
TSVTFSELKG FAERLQRNES GLDSGRSQRL ALLLRNATQH TSGYFGSDVK
1310 1320 1330 1340 1350
VAYQLATRLL AHESAQRGFG LSATQDVHFT ENLLRVGSAL LDAANKRHWE
1360 1370 1380 1390 1400
LIQQTEGGTA WLLQHYEAYA SALAQNMRHT YLSPFTIVTP NIVISVVRLD
1410 1420 1430 1440 1450
KGNFAGTKLP RYEALRGERP PDLETTVILP ESVFREMPPM VRSAGPGEAQ
1460 1470 1480 1490 1500
ETEELARRQR RHPELSQGEA VASVIIYHTL AGLLPHNYDP DKRSLRVPKR
1510 1520 1530 1540 1550
PVINTPVVSI SVHDDEELLP RALDKPVTVQ FRLLETEERT KPICVFWNHS
1560 1570 1580 1590 1600
ILVSGTGGWS ARGCEVVFRN ESHVSCQCNH MTSFAVLMDV SRRENGEILP
1610 1620 1630 1640 1650
LKTLTYVALG VTLAALMITF LFLTLLRALR SNQHGIRRNL TAALGLAQLV
1660 1670 1680 1690 1700
FLLGINQADL PFACTVIAIL LHFLYLCTFS WALLEALHLY RALTEVRDVN
1710 1720 1730 1740 1750
ASPMRFYYML GWGVPAFITG LAVGLDPEGY GNPDFCWLSI YDTLIWSFAG
1760 1770 1780 1790 1800
PVAFAVSMSV FLYILSARAS CAAQRQGFEK KGPVSGLRSS FTVLLLLSAT
1810 1820 1830 1840 1850
WLLALLSVNS DTLLFHYLFA ACNCVQGPFI FLSYVVLSKE VRKALKFACS
1860 1870 1880 1890 1900
RKPSPDPALT TKSTLTSSYN CPSPYADGRL YQPYGDSAGS LHSASRSGKS
1910 1920 1930 1940 1950
QPSYIPFLLR EESTLNPGQV PPGLGDPSGL FMEGQAQQHD PDTDSDSDLS
1960 1970 1980 1990 2000
LEDDQSGSYA STHSSDSEEE EEEAAFPGEQ GWDSLLGPGA ERLPLHSTPK
2010 2020 2030 2040 2050
DGGPGSGKVP WPGDFGTTTK ENSGSGPLEE RPRENGDALT REGSLGPLPG
2060 2070 2080 2090 2100
PSTQPHKGIL KKKCLPTISE KSSLLRLPLE QGTGSSRGST ASEGSRNGPP
2110 2120 2130 2140
PRPPPRQSLQ EQLNGVMPIA MSIKAGTVDE DSSGSEFLFF NFLH
Length:2,144
Mass (Da):233,481
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EA898C1BA655ECA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8P3G3V8P3_RAT
Cadherin EGF LAG seven-pass G-type ...
Celsr2 rCG_28504
2,919Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011529 mRNA Translation: BAA88687.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:69237 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011529 mRNA Translation: BAA88687.1

3D structure databases

SMRiQ9QYP2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027263

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ9QYP2
PhosphoSitePlusiQ9QYP2
UniCarbKBiQ9QYP2

Proteomic databases

jPOSTiQ9QYP2
PaxDbiQ9QYP2
PRIDEiQ9QYP2

Genome annotation databases

UCSCiRGD:69237 rat

Organism-specific databases

RGDi69237 Celsr2

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
HOGENOMiHOG000231346
InParanoidiQ9QYP2
PhylomeDBiQ9QYP2

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 2 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 3 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 4 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QYP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: June 5, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again