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Entry version 120 (07 Oct 2020)
Sequence version 2 (16 Dec 2008)
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Protein

Multiple epidermal growth factor-like domains protein 8

Gene

Megf8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of hedgehog signaling.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 8
Short name:
Multiple EGF-like domains protein 8
Alternative name(s):
Epidermal growth factor-like protein 4
Short name:
EGF-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Megf8
Synonyms:Egfl4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
621190, Megf8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 2590ExtracellularSequence analysisAdd BLAST2563
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2591 – 2611HelicalSequence analysisAdd BLAST21
Topological domaini2612 – 2788CytoplasmicSequence analysisAdd BLAST177

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005563128 – 2788Multiple epidermal growth factor-like domains protein 8Add BLAST2761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 57By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 152By similarity
Disulfide bondi146 ↔ 158By similarity
Disulfide bondi174 ↔ 184By similarity
Disulfide bondi178 ↔ 191By similarity
Disulfide bondi193 ↔ 202By similarity
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1078 ↔ 1091By similarity
Disulfide bondi1085 ↔ 1100By similarity
Disulfide bondi1102 ↔ 1114By similarity
Disulfide bondi1163 ↔ 1171By similarity
Disulfide bondi1165 ↔ 1179By similarity
Disulfide bondi1182 ↔ 1191By similarity
Disulfide bondi1194 ↔ 1208By similarity
Disulfide bondi1211 ↔ 1224By similarity
Disulfide bondi1213 ↔ 1231By similarity
Disulfide bondi1233 ↔ 1242By similarity
Disulfide bondi1245 ↔ 1259By similarity
Disulfide bondi1263 ↔ 1302By similarity
Glycosylationi1271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1336 ↔ 1367By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1353PhosphothreonineCombined sources1
Disulfide bondi1407 ↔ 1421By similarity
Disulfide bondi1415 ↔ 1433By similarity
Disulfide bondi1435 ↔ 1444By similarity
Glycosylationi2009N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2125 ↔ 2138By similarity
Disulfide bondi2132 ↔ 2147By similarity
Glycosylationi2157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2196 ↔ 2204By similarity
Disulfide bondi2198 ↔ 2213By similarity
Disulfide bondi2216 ↔ 2225By similarity
Disulfide bondi2228 ↔ 2242By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QYP0

PRoteomics IDEntifications database

More...
PRIDEi
Q9QYP0

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9QYP0, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QYP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QYP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9QYP0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000027831

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QYP0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 140CUB 1PROSITE-ProRule annotationAdd BLAST111
Domaini138 – 168EGF-like 1PROSITE-ProRule annotationAdd BLAST31
Domaini170 – 203EGF-like 2PROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati241 – 287Kelch 1Add BLAST47
Repeati290 – 338Kelch 2Add BLAST49
Repeati346 – 399Kelch 3Add BLAST54
Repeati402 – 453Kelch 4Add BLAST52
Repeati459 – 511Kelch 5Add BLAST53
Repeati525 – 575Kelch 6Add BLAST51
Domaini561 – 613PSI 1Add BLAST53
Domaini847 – 899PSI 2Add BLAST53
Domaini900 – 947PSI 3Add BLAST48
Domaini1074 – 1115EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1163 – 1210Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST48
Domaini1211 – 1261Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST51
Domaini1263 – 1405CUB 2PROSITE-ProRule annotationAdd BLAST143
Domaini1403 – 1445EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Repeati1522 – 1570Kelch 7Add BLAST49
Repeati1580 – 1626Kelch 8Add BLAST47
Repeati1632 – 1678Kelch 9Add BLAST47
Repeati1684 – 1734Kelch 10Add BLAST51
Repeati1739 – 1786Kelch 11Add BLAST48
Repeati1795 – 1840Kelch 12Add BLAST46
Domaini1819 – 1859PSI 4Add BLAST41
Domaini1867 – 1922PSI 5Add BLAST56
Domaini2003 – 2061PSI 6Add BLAST59
Domaini2063 – 2120PSI 7Add BLAST58
Domaini2121 – 2159EGF-like 5PROSITE-ProRule annotationAdd BLAST39
Domaini2196 – 2244Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST49
Domaini2323 – 2386Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2471 – 2486Pro-richAdd BLAST16
Compositional biasi2682 – 2776Gly-richAdd BLAST95

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1388, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QYP0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QYP0

TreeFam database of animal gene trees

More...
TreeFami
TF321873

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 4 hits
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 6 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 4 hits
PS50027, EGF_LAM_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QYP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGGALAAA LALAFAVLGP LSHKVLAGDC KGQRQVLREA PGFVTDGAGN
60 70 80 90 100
YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPQGPLLA
110 120 130 140 150
SLSGSTRPPP IEASSGKMLL HLFSDANYNL LGFNASFRFS LCPGGCQNHG
160 170 180 190 200
QCKSPGVCVC EPGWGGPDCG LQECSAYCGS HGTCASTLGP CRCEPGFLGR
210 220 230 240 250
ACDLHLWENQ GAGWWHSVSA GDPAFSARVG AAGAFLSPPG LLAVFGGQDL
260 270 280 290 300
NKALGDLVLY NFSTNTWESW DLTPAPAARH SHVAVAWAGF LVLMGGELAN
310 320 330 340 350
GLLTNDVWAF SPLGGGHWEL LAPPASSSSG PPGLAGHAAA LVDDIWLYVS
360 370 380 390 400
GGRTQHDLFS SGLFRFRLDH TSRGYWEQVI PAGGRPPAAT GHSMVFHAPS
410 420 430 440 450
RTLLVHGGHR PSTARFSVRV NSTELFHVDR RVWTTLKGRD GLQGPRERAF
460 470 480 490 500
HTASVLGNYM VVYGGNVHTH YQEEKCYEDG IFFYHLGCHQ WVSGAELAPP
510 520 530 540 550
GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL MAYKVPPFVF
560 570 580 590 600
QAPALDYHLD YCSMYTDHSV CSRDPECSWC QGACQSAPPP GTPSGACPAA
610 620 630 640 650
SCLGLGRLLS DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR
660 670 680 690 700
GEQISGTVGW WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV
710 720 730 740 750
SIVRSTTITL TPSAETDVSL VYRGFIYPML PGGPGGPGAE DVAVWARAQR
760 770 780 790 800
LHVLARMARG PDTENMEEVG RWVAQQEKET RRLQRPGSSR LFPLPGRGNK
810 820 830 840 850
YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL EPYRSLACSS
860 870 880 890 900
YSSCLGCLAD QGCGWCLNSA TCHLRQGRAH CEDDGNGESL LVLVPALCPL
910 920 930 940 950
CEEHRDCHAC TQDPFCEWHQ STNRKGDAAC SRRGRGRGAL KNPEECPPLC
960 970 980 990 1000
SQRLTCEDCL ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE
1010 1020 1030 1040 1050
PRCRSCHGFL TCHECLQSHE CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS
1060 1070 1080 1090 1100
LWVGEGLGLP VALPARWAYA RCPDVDECRL GLARCHPRAT CLNTPLSYEC
1110 1120 1130 1140 1150
HCQRGYQGDG ITHCNRTCLE DCGHGVCSGP PDFTCVCDLG WTSDLPPPTP
1160 1170 1180 1190 1200
APGPPAPRCS RDCGCNFHSH CRRRGPGYCD ECQDWTWGEH CERCRPGSFG
1210 1220 1230 1240 1250
NATGSGGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQICSPGYY
1260 1270 1280 1290 1300
GDPRAGGSCF RECGGRALLT NVSSVALGSR RFGGLLPPGG GTARAGPGLS
1310 1320 1330 1340 1350
YCVWVVSATE ALQPCAPGTL CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF
1360 1370 1380 1390 1400
LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL SGLLVLHWEA NGSSSWGFNA
1410 1420 1430 1440 1450
SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA GPHCRMALCP
1460 1470 1480 1490 1500
ENCNAHTGAG ICNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS
1510 1520 1530 1540 1550
ADTASRFLHR LGHTMVEGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT
1560 1570 1580 1590 1600
QMLAGAEDGG PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GITCDFWVLN
1610 1620 1630 1640 1650
LTTLQWRQEK APQSIELPAV AGHTLTARRG LSLLLVGGYS PENGFNQQLL
1660 1670 1680 1690 1700
EYQLATTWVS GAQSGTPPTG LYGHSAVYHE ATDSLYVFGG FRFHVELAAP
1710 1720 1730 1740 1750
SPELYSLHCP DRTWSLLAPS QGAKPRPRLF HASALLGDTM VVLGGRSDPD
1760 1770 1780 1790 1800
EFSSDVLLYQ VNCNTWLLPD LTRPAFVGSP MEESVAHAVA AVGSRLYISG
1810 1820 1830 1840 1850
GFGGVALGRL LALTLPPDPC RLLPSPEACN QSGACTWCHG ACLSGDQAHR
1860 1870 1880 1890 1900
LGCGVPPCSP MPRSPEECRR LRTCSECLAR HPRTLQPGDG EASVPRCKWC
1910 1920 1930 1940 1950
TNCPEGACIG RNGSCTSEND CRINQREVFW AGNCSEAACG AADCEQCTRE
1960 1970 1980 1990 2000
GKCMWTRQFK RTGETRRILS VQPTYDWTCF SHSLLNVSPM PVESSPPLPC
2010 2020 2030 2040 2050
PTPCHLLPNC TSCLASKGAD GGWQHCVWSS SLQQCLSPSY LPLRCMAGGC
2060 2070 2080 2090 2100
GRLLRGPESC SLGCAQATQC ALCLRRPHCG WCAWGGQDGG GHCMEGGLSG
2110 2120 2130 2140 2150
PRDGLTCGRP GASWAFLSCP PEDECANGHH DCNETQNCHD QPHGYECSCK
2160 2170 2180 2190 2200
TGYTMDNVTG VCRPVCAQGC VNGSCVEPDH CRCHFGFVGR NCSTECRCNR
2210 2220 2230 2240 2250
HSECAGVGAR DHCLLCRNHT KGSHCEQCLP LFVGSALGGG TCRPCHAFCR
2260 2270 2280 2290 2300
GNSHVCVSRK ELEMARREPE KYSLDPEEIE AWVAEGPSED EAVCVNCQNN
2310 2320 2330 2340 2350
SYGDRCESCL HGYFLLDGKC TKCQCNGHAD TCNEQDGTGC PCQNNTETGV
2360 2370 2380 2390 2400
CQGSSPSDRR DCYKYQCAKC RESFHGSPLG GQQCYRLISV EQECCLDPTS
2410 2420 2430 2440 2450
QTNCFHEPKR RALGPGRTVL FGVQPKFTNV DIRLTLDVTF GAVDLYVSTS
2460 2470 2480 2490 2500
YDTFVVRVAP DTGVHTVHIQ PPPPPPPPPP PADGVPRVAS DLGGLGTGSG
2510 2520 2530 2540 2550
SGSPVEPRVR EVWPRGLITY VTVTEPSAVL VVRSVRDRLV ITYPHEHHAL
2560 2570 2580 2590 2600
KSSRFYLLLL GVGDPNGPGA NGSADSQGLL FFRQDQAHID LFVFFSVFFS
2610 2620 2630 2640 2650
CFFLFLSLCV LLWKAKQALD QRQEQRRHLQ EMTKMASRPF AKVTVCFPPD
2660 2670 2680 2690 2700
PAGPAPAWKP AGLPPPAFRR SEPFLAPLLL TGAGGPWGPM GGGCCPPALP
2710 2720 2730 2740 2750
ATTAGLRAGP ITLEPTEDGM AGVATLLLQL PGGPHAPNGA CLGSALVTLR
2760 2770 2780
HRLHEYCGGS GGAGGSGHGG GGGRKGLLSQ DNLTSMSL
Length:2,788
Mass (Da):297,554
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CFB8141F3E03C10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R9PXW3R9PXW3_RAT
Multiple epidermal growth factor-li...
Megf8
2,789Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR03001918 Genomic DNA No translation available.
AABR03001941 Genomic DNA No translation available.
AABR03004237 Genomic DNA No translation available.
AB011534 mRNA Translation: BAA88689.1

Genome annotation databases

UCSC genome browser

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UCSCi
RGD:621190, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03001918 Genomic DNA No translation available.
AABR03001941 Genomic DNA No translation available.
AABR03004237 Genomic DNA No translation available.
AB011534 mRNA Translation: BAA88689.1

3D structure databases

SMRiQ9QYP0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9QYP0, 1 interactor
STRINGi10116.ENSRNOP00000027831

PTM databases

GlyGeniQ9QYP0, 6 sites
iPTMnetiQ9QYP0
PhosphoSitePlusiQ9QYP0

Proteomic databases

PaxDbiQ9QYP0
PRIDEiQ9QYP0

Genome annotation databases

UCSCiRGD:621190, rat

Organism-specific databases

RGDi621190, Megf8

Phylogenomic databases

eggNOGiKOG1388, Eukaryota
InParanoidiQ9QYP0
PhylomeDBiQ9QYP0
TreeFamiTF321873

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9QYP0

Family and domain databases

CDDicd00041, CUB, 1 hit
Gene3Di2.120.10.80, 4 hits
2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits
SUPFAMiSSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 6 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 4 hits
PS50027, EGF_LAM_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEGF8_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QYP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 16, 2008
Last modified: October 7, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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