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UniProtKB - Q9QYP0 (MEGF8_RAT)

Entry version 120 (07 Oct 2020)
Sequence version 2 (16 Dec 2008)
Previous versions | rss
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Protein

Multiple epidermal growth factor-like domains protein 8

Gene

Megf8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of hedgehog signaling.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 8
Short name:
Multiple EGF-like domains protein 8
Alternative name(s):
Epidermal growth factor-like protein 4
Short name:
EGF-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Megf8
Synonyms:Egfl4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		621190, Megf8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 2590ExtracellularSequence analysisAdd BLAST2563
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2591 – 2611HelicalSequence analysisAdd BLAST21
Topological domaini2612 – 2788CytoplasmicSequence analysisAdd BLAST177

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005563128 – 2788Multiple epidermal growth factor-like domains protein 8Add BLAST2761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 57By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 152By similarity
Disulfide bondi146 ↔ 158By similarity
Disulfide bondi174 ↔ 184By similarity
Disulfide bondi178 ↔ 191By similarity
Disulfide bondi193 ↔ 202By similarity
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1078 ↔ 1091By similarity
Disulfide bondi1085 ↔ 1100By similarity
Disulfide bondi1102 ↔ 1114By similarity
Disulfide bondi1163 ↔ 1171By similarity
Disulfide bondi1165 ↔ 1179By similarity
Disulfide bondi1182 ↔ 1191By similarity
Disulfide bondi1194 ↔ 1208By similarity
Disulfide bondi1211 ↔ 1224By similarity
Disulfide bondi1213 ↔ 1231By similarity
Disulfide bondi1233 ↔ 1242By similarity
Disulfide bondi1245 ↔ 1259By similarity
Disulfide bondi1263 ↔ 1302By similarity
Glycosylationi1271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1336 ↔ 1367By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1353PhosphothreonineCombined sources1
Disulfide bondi1407 ↔ 1421By similarity
Disulfide bondi1415 ↔ 1433By similarity
Disulfide bondi1435 ↔ 1444By similarity
Glycosylationi2009N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2125 ↔ 2138By similarity
Disulfide bondi2132 ↔ 2147By similarity
Glycosylationi2157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2196 ↔ 2204By similarity
Disulfide bondi2198 ↔ 2213By similarity
Disulfide bondi2216 ↔ 2225By similarity
Disulfide bondi2228 ↔ 2242By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QYP0

PRoteomics IDEntifications database

More...PRIDEi		Q9QYP0

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9QYP0, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QYP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QYP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9QYP0, 1 interactor

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000027831

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QYP0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 140CUB 1PROSITE-ProRule annotationAdd BLAST111
Domaini138 – 168EGF-like 1PROSITE-ProRule annotationAdd BLAST31
Domaini170 – 203EGF-like 2PROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati241 – 287Kelch 1Add BLAST47
Repeati290 – 338Kelch 2Add BLAST49
Repeati346 – 399Kelch 3Add BLAST54
Repeati402 – 453Kelch 4Add BLAST52
Repeati459 – 511Kelch 5Add BLAST53
Repeati525 – 575Kelch 6Add BLAST51
Domaini561 – 613PSI 1Add BLAST53
Domaini847 – 899PSI 2Add BLAST53
Domaini900 – 947PSI 3Add BLAST48
Domaini1074 – 1115EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1163 – 1210Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST48
Domaini1211 – 1261Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST51
Domaini1263 – 1405CUB 2PROSITE-ProRule annotationAdd BLAST143
Domaini1403 – 1445EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Repeati1522 – 1570Kelch 7Add BLAST49
Repeati1580 – 1626Kelch 8Add BLAST47
Repeati1632 – 1678Kelch 9Add BLAST47
Repeati1684 – 1734Kelch 10Add BLAST51
Repeati1739 – 1786Kelch 11Add BLAST48
Repeati1795 – 1840Kelch 12Add BLAST46
Domaini1819 – 1859PSI 4Add BLAST41
Domaini1867 – 1922PSI 5Add BLAST56
Domaini2003 – 2061PSI 6Add BLAST59
Domaini2063 – 2120PSI 7Add BLAST58
Domaini2121 – 2159EGF-like 5PROSITE-ProRule annotationAdd BLAST39
Domaini2196 – 2244Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST49
Domaini2323 – 2386Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2471 – 2486Pro-richAdd BLAST16
Compositional biasi2682 – 2776Gly-richAdd BLAST95

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1388, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QYP0

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9QYP0

TreeFam database of animal gene trees

More...TreeFami		TF321873

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.80, 4 hits
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 6 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 4 hits
PS50027, EGF_LAM_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QYP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGGALAAA LALAFAVLGP LSHKVLAGDC KGQRQVLREA PGFVTDGAGN 
        60         70         80         90        100
YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPQGPLLA 
       110        120        130        140        150
SLSGSTRPPP IEASSGKMLL HLFSDANYNL LGFNASFRFS LCPGGCQNHG 
       160        170        180        190        200
QCKSPGVCVC EPGWGGPDCG LQECSAYCGS HGTCASTLGP CRCEPGFLGR 
       210        220        230        240        250
ACDLHLWENQ GAGWWHSVSA GDPAFSARVG AAGAFLSPPG LLAVFGGQDL 
       260        270        280        290        300
NKALGDLVLY NFSTNTWESW DLTPAPAARH SHVAVAWAGF LVLMGGELAN 
       310        320        330        340        350
GLLTNDVWAF SPLGGGHWEL LAPPASSSSG PPGLAGHAAA LVDDIWLYVS 
       360        370        380        390        400
GGRTQHDLFS SGLFRFRLDH TSRGYWEQVI PAGGRPPAAT GHSMVFHAPS 
       410        420        430        440        450
RTLLVHGGHR PSTARFSVRV NSTELFHVDR RVWTTLKGRD GLQGPRERAF 
       460        470        480        490        500
HTASVLGNYM VVYGGNVHTH YQEEKCYEDG IFFYHLGCHQ WVSGAELAPP 
       510        520        530        540        550
GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL MAYKVPPFVF 
       560        570        580        590        600
QAPALDYHLD YCSMYTDHSV CSRDPECSWC QGACQSAPPP GTPSGACPAA 
       610        620        630        640        650
SCLGLGRLLS DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR 
       660        670        680        690        700
GEQISGTVGW WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV 
       710        720        730        740        750
SIVRSTTITL TPSAETDVSL VYRGFIYPML PGGPGGPGAE DVAVWARAQR 
       760        770        780        790        800
LHVLARMARG PDTENMEEVG RWVAQQEKET RRLQRPGSSR LFPLPGRGNK 
       810        820        830        840        850
YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL EPYRSLACSS 
       860        870        880        890        900
YSSCLGCLAD QGCGWCLNSA TCHLRQGRAH CEDDGNGESL LVLVPALCPL 
       910        920        930        940        950
CEEHRDCHAC TQDPFCEWHQ STNRKGDAAC SRRGRGRGAL KNPEECPPLC 
       960        970        980        990       1000
SQRLTCEDCL ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE 
      1010       1020       1030       1040       1050
PRCRSCHGFL TCHECLQSHE CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS 
      1060       1070       1080       1090       1100
LWVGEGLGLP VALPARWAYA RCPDVDECRL GLARCHPRAT CLNTPLSYEC 
      1110       1120       1130       1140       1150
HCQRGYQGDG ITHCNRTCLE DCGHGVCSGP PDFTCVCDLG WTSDLPPPTP 
      1160       1170       1180       1190       1200
APGPPAPRCS RDCGCNFHSH CRRRGPGYCD ECQDWTWGEH CERCRPGSFG 
      1210       1220       1230       1240       1250
NATGSGGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQICSPGYY 
      1260       1270       1280       1290       1300
GDPRAGGSCF RECGGRALLT NVSSVALGSR RFGGLLPPGG GTARAGPGLS 
      1310       1320       1330       1340       1350
YCVWVVSATE ALQPCAPGTL CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF 
      1360       1370       1380       1390       1400
LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL SGLLVLHWEA NGSSSWGFNA 
      1410       1420       1430       1440       1450
SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA GPHCRMALCP 
      1460       1470       1480       1490       1500
ENCNAHTGAG ICNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 
      1510       1520       1530       1540       1550
ADTASRFLHR LGHTMVEGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT 
      1560       1570       1580       1590       1600
QMLAGAEDGG PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GITCDFWVLN 
      1610       1620       1630       1640       1650
LTTLQWRQEK APQSIELPAV AGHTLTARRG LSLLLVGGYS PENGFNQQLL 
      1660       1670       1680       1690       1700
EYQLATTWVS GAQSGTPPTG LYGHSAVYHE ATDSLYVFGG FRFHVELAAP 
      1710       1720       1730       1740       1750
SPELYSLHCP DRTWSLLAPS QGAKPRPRLF HASALLGDTM VVLGGRSDPD 
      1760       1770       1780       1790       1800
EFSSDVLLYQ VNCNTWLLPD LTRPAFVGSP MEESVAHAVA AVGSRLYISG 
      1810       1820       1830       1840       1850
GFGGVALGRL LALTLPPDPC RLLPSPEACN QSGACTWCHG ACLSGDQAHR 
      1860       1870       1880       1890       1900
LGCGVPPCSP MPRSPEECRR LRTCSECLAR HPRTLQPGDG EASVPRCKWC 
      1910       1920       1930       1940       1950
TNCPEGACIG RNGSCTSEND CRINQREVFW AGNCSEAACG AADCEQCTRE 
      1960       1970       1980       1990       2000
GKCMWTRQFK RTGETRRILS VQPTYDWTCF SHSLLNVSPM PVESSPPLPC 
      2010       2020       2030       2040       2050
PTPCHLLPNC TSCLASKGAD GGWQHCVWSS SLQQCLSPSY LPLRCMAGGC 
      2060       2070       2080       2090       2100
GRLLRGPESC SLGCAQATQC ALCLRRPHCG WCAWGGQDGG GHCMEGGLSG 
      2110       2120       2130       2140       2150
PRDGLTCGRP GASWAFLSCP PEDECANGHH DCNETQNCHD QPHGYECSCK 
      2160       2170       2180       2190       2200
TGYTMDNVTG VCRPVCAQGC VNGSCVEPDH CRCHFGFVGR NCSTECRCNR 
      2210       2220       2230       2240       2250
HSECAGVGAR DHCLLCRNHT KGSHCEQCLP LFVGSALGGG TCRPCHAFCR 
      2260       2270       2280       2290       2300
GNSHVCVSRK ELEMARREPE KYSLDPEEIE AWVAEGPSED EAVCVNCQNN 
      2310       2320       2330       2340       2350
SYGDRCESCL HGYFLLDGKC TKCQCNGHAD TCNEQDGTGC PCQNNTETGV 
      2360       2370       2380       2390       2400
CQGSSPSDRR DCYKYQCAKC RESFHGSPLG GQQCYRLISV EQECCLDPTS 
      2410       2420       2430       2440       2450
QTNCFHEPKR RALGPGRTVL FGVQPKFTNV DIRLTLDVTF GAVDLYVSTS 
      2460       2470       2480       2490       2500
YDTFVVRVAP DTGVHTVHIQ PPPPPPPPPP PADGVPRVAS DLGGLGTGSG 
      2510       2520       2530       2540       2550
SGSPVEPRVR EVWPRGLITY VTVTEPSAVL VVRSVRDRLV ITYPHEHHAL 
      2560       2570       2580       2590       2600
KSSRFYLLLL GVGDPNGPGA NGSADSQGLL FFRQDQAHID LFVFFSVFFS 
      2610       2620       2630       2640       2650
CFFLFLSLCV LLWKAKQALD QRQEQRRHLQ EMTKMASRPF AKVTVCFPPD 
      2660       2670       2680       2690       2700
PAGPAPAWKP AGLPPPAFRR SEPFLAPLLL TGAGGPWGPM GGGCCPPALP 
      2710       2720       2730       2740       2750
ATTAGLRAGP ITLEPTEDGM AGVATLLLQL PGGPHAPNGA CLGSALVTLR 
      2760       2770       2780 
HRLHEYCGGS GGAGGSGHGG GGGRKGLLSQ DNLTSMSL
Length:2,788
Mass (Da):297,554
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CFB8141F3E03C10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R9PXW3R9PXW3_RAT
Multiple epidermal growth factor-li...
Megf8
2,789Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR03001918 Genomic DNA No translation available.
AABR03001941 Genomic DNA No translation available.
AABR03004237 Genomic DNA No translation available.
AB011534 mRNA Translation: BAA88689.1

Genome annotation databases

UCSC genome browser

More...UCSCi		RGD:621190, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03001918 Genomic DNA No translation available.
AABR03001941 Genomic DNA No translation available.
AABR03004237 Genomic DNA No translation available.
AB011534 mRNA Translation: BAA88689.1

3D structure databases

SMRiQ9QYP0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9QYP0, 1 interactor
STRINGi10116.ENSRNOP00000027831

PTM databases

GlyGeniQ9QYP0, 6 sites
iPTMnetiQ9QYP0
PhosphoSitePlusiQ9QYP0

Proteomic databases

PaxDbiQ9QYP0
PRIDEiQ9QYP0

Genome annotation databases

UCSCiRGD:621190, rat

Organism-specific databases

RGDi621190, Megf8

Phylogenomic databases

eggNOGiKOG1388, Eukaryota
InParanoidiQ9QYP0
PhylomeDBiQ9QYP0
TreeFamiTF321873

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9QYP0

Family and domain databases

CDDicd00041, CUB, 1 hit
Gene3Di2.120.10.80, 4 hits
2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR015915, Kelch-typ_b-propeller
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF12947, EGF_3, 1 hit
PF07645, EGF_CA, 1 hit
PF00053, Laminin_EGF, 4 hits
PF01437, PSI, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00181, EGF, 13 hits
SM00179, EGF_CA, 2 hits
SM00180, EGF_Lam, 4 hits
SM00423, PSI, 9 hits
SUPFAMiSSF117281, SSF117281, 2 hits
SSF49854, SSF49854, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 2 hits
PS00022, EGF_1, 6 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 1 hit
PS01248, EGF_LAM_1, 4 hits
PS50027, EGF_LAM_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEGF8_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QYP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 16, 2008
Last modified: October 7, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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