UniProtKB - Q9QYN8 (HRH3_RAT)
Histamine H3 receptor
Hrh3
Functioni
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).
Miscellaneous
GO - Molecular functioni
- amine binding Source: RGD
- G protein-coupled acetylcholine receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: GO_Central
- heterocyclic compound binding Source: RGD
- histamine receptor activity Source: InterPro
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
- brain development Source: RGD
- chemical synaptic transmission Source: GO_Central
- cognition Source: RGD
- drinking behavior Source: RGD
- eating behavior Source: RGD
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- learning Source: RGD
- memory Source: RGD
- negative regulation of adenylate cyclase activity Source: RGD
- negative regulation of blood pressure Source: RGD
- negative regulation of gamma-aminobutyric acid secretion Source: RGD
- negative regulation of glutamate secretion Source: RGD
- negative regulation of serotonin secretion Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of epithelial cell proliferation Source: RGD
- regulation of neurotransmitter levels Source: InterPro
- regulation of norepinephrine secretion Source: RGD
- response to organic cyclic compound Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-390650, Histamine receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Histamine H3 receptorShort name: H3R Short name: HH3R |
Gene namesi | Name:Hrh3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620630, Hrh3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
- dendrite Source: GO_Central
- myelin sheath Source: RGD
- neuron projection Source: RGD
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 60 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 61 – 70 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 71 – 91 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 92 – 108 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 109 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 156 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 157 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 196 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 197 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 218 – 359 | CytoplasmicSequence analysisAdd BLAST | 142 | |
Transmembranei | 360 – 380 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 381 – 396 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 397 – 417 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 418 – 445 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4124 |
DrugCentrali | Q9QYN8 |
GuidetoPHARMACOLOGYi | 264 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069692 | 1 – 445 | Histamine H3 receptorAdd BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinPTM databases
GlyGeni | Q9QYN8, 1 site |
PhosphoSitePlusi | Q9QYN8 |
Expressioni
Tissue specificityi
Interactioni
Protein-protein interaction databases
BioGRIDi | 250072, 1 interactor |
Chemistry databases
BindingDBi | Q9QYN8 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 234 – 259 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 286 – 336 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 242 – 259 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 299 – 314 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q9QYN8 |
OMAi | APGCWGC |
PhylomeDBi | Q9QYN8 |
Family and domain databases
CDDi | cd15296, 7tmA_Histamine_H3R, 1 hit |
InterProi | View protein in InterPro IPR041998, 7tmA_HRH3 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003980, Histamine_H3_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01471, HISTAMINEH3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERAPPDGLM NASGTLAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL
60 70 80 90 100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW
110 120 130 140 150
TFGRGLCKLW LVVDYLLCAS SVFNIVLISY DRFLSVTRAV SYRAQQGDTR
160 170 180 190 200
RAVRKMALVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI
210 220 230 240 250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG PEPPPDAQPS
260 270 280 290 300
PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVEAGEAA LGGGSGGGAA
310 320 330 340 350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL
360 370 380 390 400
SRDKKVAKSL AIIVSIFGLC WAPYTLLMII RAACHGRCIP DYWYETSFWL
410 420 430 440
LWANSAVNPV LYPLCHYSFR RAFTKLLCPQ KLKVQPHGSL EQCWK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JU84 | A0A0G2JU84_RAT | Histamine H3 receptor | Hrh3 | 488 | Annotation score: | ||
Q2VJ17 | Q2VJ17_RAT | Histamine H3 receptor | Hrh3 | 465 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001888 | 274 – 321 | Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_001887 | 274 – 305 | Missing in isoform 2. 2 PublicationsAdd BLAST | 32 | |
Alternative sequenceiVSP_001889 | 393 – 445 | WYETS…EQCWK → CVERLGKLEASLLLPLWMFS GRWRRRKHVCELDVPWMFNQ ERQNCRGARGWIGRCGLPRP PPSVLQLPAEPRQLLLPAPP PGLGRWPCPACPVCTIRIWG WVVMG in isoform 4. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237919 mRNA Translation: AAF82086.1 AY009370 mRNA Translation: AAK02069.1 AB015646 mRNA Translation: BAA88765.1 AB015646 mRNA Translation: BAA88766.1 AB015646 mRNA Translation: BAA88767.1 AB015646 mRNA Translation: BAA88768.1 |
RefSeqi | NP_001257493.1, NM_001270564.1 [Q9QYN8-2] NP_001257494.1, NM_001270565.1 [Q9QYN8-3] NP_001257497.1, NM_001270568.1 [Q9QYN8-4] NP_445958.1, NM_053506.2 [Q9QYN8-1] |
Genome annotation databases
GeneIDi | 85268 |
KEGGi | rno:85268 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237919 mRNA Translation: AAF82086.1 AY009370 mRNA Translation: AAK02069.1 AB015646 mRNA Translation: BAA88765.1 AB015646 mRNA Translation: BAA88766.1 AB015646 mRNA Translation: BAA88767.1 AB015646 mRNA Translation: BAA88768.1 |
RefSeqi | NP_001257493.1, NM_001270564.1 [Q9QYN8-2] NP_001257494.1, NM_001270565.1 [Q9QYN8-3] NP_001257497.1, NM_001270568.1 [Q9QYN8-4] NP_445958.1, NM_053506.2 [Q9QYN8-1] |
3D structure databases
SMRi | Q9QYN8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250072, 1 interactor |
Chemistry databases
BindingDBi | Q9QYN8 |
ChEMBLi | CHEMBL4124 |
DrugCentrali | Q9QYN8 |
GuidetoPHARMACOLOGYi | 264 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9QYN8, 1 site |
PhosphoSitePlusi | Q9QYN8 |
Genome annotation databases
GeneIDi | 85268 |
KEGGi | rno:85268 |
Organism-specific databases
CTDi | 11255 |
RGDi | 620630, Hrh3 |
Phylogenomic databases
InParanoidi | Q9QYN8 |
OMAi | APGCWGC |
PhylomeDBi | Q9QYN8 |
Enzyme and pathway databases
Reactomei | R-RNO-390650, Histamine receptors |
Miscellaneous databases
PROi | PR:Q9QYN8 |
Family and domain databases
CDDi | cd15296, 7tmA_Histamine_H3R, 1 hit |
InterProi | View protein in InterPro IPR041998, 7tmA_HRH3 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003980, Histamine_H3_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01471, HISTAMINEH3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HRH3_RAT | |
Accessioni | Q9QYN8Primary (citable) accession number: Q9QYN8 Secondary accession number(s): Q9QYN6, Q9QYN7, Q9QYN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families