Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kallikrein-11

Gene

Klk11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Charge relay systemBy similarity1
Active sitei136Charge relay systemBy similarity1
Active sitei229Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.257

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-11 (EC:3.4.21.-)
Alternative name(s):
Hippostasin
Serine protease 20
Gene namesi
Name:Klk11
Synonyms:Prss20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929977 Klk11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
PropeptideiPRO_000022418545 – 47Activation peptideSequence analysis3
ChainiPRO_000022418648 – 276Kallikrein-11Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 189PROSITE-ProRule annotation
Disulfide bondi73 ↔ 89PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 235PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 214PROSITE-ProRule annotation
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 250PROSITE-ProRule annotation
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9QYN3
PRIDEiQ9QYN3

PTM databases

iPTMnetiQ9QYN3
PhosphoSitePlusiQ9QYN3

Expressioni

Tissue specificityi

Expressed in brain and prostate (isoform 1) and prostate (isoform 2).1 Publication

Gene expression databases

BgeeiENSMUSG00000067616 Expressed in 41 organ(s), highest expression level in esophagus
CleanExiMM_KLK11
ExpressionAtlasiQ9QYN3 baseline and differential
GenevisibleiQ9QYN3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079101

Structurei

3D structure databases

ProteinModelPortaliQ9QYN3
SMRiQ9QYN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 274Peptidase S1PROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9QYN3
KOiK09620
OMAiENAYPGN
OrthoDBiEOG091G0DF7
PhylomeDBiQ9QYN3
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q9QYN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRLKSDWKL STETREPGAR PALLQARMIL RLIALALVTG HVGGETRIIK
60 70 80 90 100
GYECRPHSQP WQVALFQKTR LLCGATLIAP KWLLTAAHCR KPHYVILLGE
110 120 130 140 150
HNLEKTDGCE QRRMATESFP HPDFNNSLPN KDHRNDIMLV KMSSPVFFTR
160 170 180 190 200
AVQPLTLSPH CVAAGTSCLI SGWGTTSSPQ LRLPHSLRCA NVSIIEHKEC
210 220 230 240 250
EKAYPGNITD TMLCASVRKE GKDSCQGDSG GPLVCNGSLQ GIISWGQDPC
260 270
AVTRKPGVYT KVCKYFNWIH EVMRNN
Length:276
Mass (Da):30,754
Last modified:May 1, 2000 - v1
Checksum:i90BDC03A8AB178D6
GO
Isoform 1 (identifier: Q9QYN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:249
Mass (Da):27,604
Checksum:iF9FF9CB457D727D5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0173181 – 27Missing in isoform 1. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016226 mRNA Translation: BAA88825.1
AB016227 mRNA Translation: BAA36955.1
AK009360 mRNA Translation: BAB26241.2
AK009720 mRNA Translation: BAB26461.2
CCDSiCCDS39935.1 [Q9QYN3-2]
CCDS52227.1 [Q9QYN3-1]
RefSeqiNP_001170844.1, NM_001177373.1 [Q9QYN3-1]
NP_064358.1, NM_019974.2 [Q9QYN3-2]
UniGeneiMm.154276

Genome annotation databases

EnsembliENSMUST00000080211; ENSMUSP00000079101; ENSMUSG00000067616 [Q9QYN3-1]
ENSMUST00000171458; ENSMUSP00000132721; ENSMUSG00000067616 [Q9QYN3-2]
GeneIDi56538
KEGGimmu:56538
UCSCiuc009gnm.1 mouse [Q9QYN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016226 mRNA Translation: BAA88825.1
AB016227 mRNA Translation: BAA36955.1
AK009360 mRNA Translation: BAB26241.2
AK009720 mRNA Translation: BAB26461.2
CCDSiCCDS39935.1 [Q9QYN3-2]
CCDS52227.1 [Q9QYN3-1]
RefSeqiNP_001170844.1, NM_001177373.1 [Q9QYN3-1]
NP_064358.1, NM_019974.2 [Q9QYN3-2]
UniGeneiMm.154276

3D structure databases

ProteinModelPortaliQ9QYN3
SMRiQ9QYN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079101

Protein family/group databases

MEROPSiS01.257

PTM databases

iPTMnetiQ9QYN3
PhosphoSitePlusiQ9QYN3

Proteomic databases

PaxDbiQ9QYN3
PRIDEiQ9QYN3

Protocols and materials databases

DNASUi56538
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080211; ENSMUSP00000079101; ENSMUSG00000067616 [Q9QYN3-1]
ENSMUST00000171458; ENSMUSP00000132721; ENSMUSG00000067616 [Q9QYN3-2]
GeneIDi56538
KEGGimmu:56538
UCSCiuc009gnm.1 mouse [Q9QYN3-1]

Organism-specific databases

CTDi11012
MGIiMGI:1929977 Klk11

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9QYN3
KOiK09620
OMAiENAYPGN
OrthoDBiEOG091G0DF7
PhylomeDBiQ9QYN3
TreeFamiTF331065

Miscellaneous databases

PROiPR:Q9QYN3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067616 Expressed in 41 organ(s), highest expression level in esophagus
CleanExiMM_KLK11
ExpressionAtlasiQ9QYN3 baseline and differential
GenevisibleiQ9QYN3 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLK11_MOUSE
AccessioniPrimary (citable) accession number: Q9QYN3
Secondary accession number(s): Q9QYN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again