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Protein

Tomoregulin-2

Gene

Tmeff2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation (By similarity).By similarity

GO - Biological processi

Protein family/group databases

MEROPSiI01.969

Names & Taxonomyi

Protein namesi
Recommended name:
Tomoregulin-2
Short name:
TR-2
Alternative name(s):
Transmembrane protein with EGF-like and two follistatin-like domains
Gene namesi
Name:Tmeff2
ORF Names:MNCb-1026
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1861735 Tmeff2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 320ExtracellularSequence analysisAdd BLAST280
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 374CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40By similarityAdd BLAST40
ChainiPRO_000001658841 – 374Tomoregulin-2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 121PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Disulfide bondi103 ↔ 135PROSITE-ProRule annotation
Disulfide bondi182 ↔ 213PROSITE-ProRule annotation
Disulfide bondi186 ↔ 206PROSITE-ProRule annotation
Disulfide bondi195 ↔ 227PROSITE-ProRule annotation
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 278By similarity
Disulfide bondi273 ↔ 289By similarity
Disulfide bondi291 ↔ 300By similarity

Post-translational modificationi

N-glycosylated. Contains chondroitin sulfate glycosaminoglycans (By similarity).By similarity
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by a metalloproteinase ADAM (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QYM9
PeptideAtlasiQ9QYM9
PRIDEiQ9QYM9

PTM databases

PhosphoSitePlusiQ9QYM9

Expressioni

Tissue specificityi

Widely expressed in the brain. In the olfactory bulb expressed in mitral cell, granule, and glomerular layers. In the hippocampus expressed in hippocampal cornu ammonis, pyramidal layer, dentate gyrus, and substantia nigra pars compacta.1 Publication

Developmental stagei

First detected at E11, reaches a maximum at E15, and remains constant through E17.1 Publication

Gene expression databases

BgeeiENSMUSG00000026109 Expressed in 213 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiQ9QYM9 baseline and differential
GenevisibleiQ9QYM9 MM

Interactioni

Protein-protein interaction databases

IntActiQ9QYM9, 1 interactor
STRINGi10090.ENSMUSP00000080533

Structurei

3D structure databases

ProteinModelPortaliQ9QYM9
SMRiQ9QYM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 137Kazal-like 1PROSITE-ProRule annotationAdd BLAST53
Domaini176 – 229Kazal-like 2PROSITE-ProRule annotationAdd BLAST54
Domaini261 – 301EGF-likePROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni303 – 320Required for sheddingBy similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 235Poly-Thr5

Sequence similaritiesi

Belongs to the tomoregulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP0A Eukaryota
ENOG4110TEU LUCA
GeneTreeiENSGT00730000110884
HOGENOMiHOG000154541
HOVERGENiHBG053816
InParanoidiQ9QYM9
OMAiNCSGFDD
OrthoDBiEOG091G0AKU
PhylomeDBiQ9QYM9
TreeFamiTF330868

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS51465 KAZAL_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QYM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLWESPRQC SSWTLCEGFC WLLLLPVTLL IIARPVKLAA FPTSLSDCQT
60 70 80 90 100
PTGWNCSGYD DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNSDYV
110 120 130 140 150
PVCGSNGESY QNECYLRQAA CKQQSEILVV SEGSCATDTG SGSGDGVHEG
160 170 180 190 200
SGETSQKETS TCDICQFGAE CDEDAEDVWC VCNIDCSQTN FNPLCASDGK
210 220 230 240 250
SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG HYARTDYAEN
260 270 280 290 300
ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC
310 320 330 340 350
EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR
360 370
IHRQKQNTGH YSSDNTTRAS TRLI
Length:374
Mass (Da):41,415
Last modified:May 1, 2000 - v1
Checksum:i2C16FEF2C3A69385
GO
Isoform 2 (identifier: Q9QYM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-262: VHEGSGETSQ...KLEESAREHH → EKFSKVMLIL...TVLKGTIPVP

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):41,603
Checksum:iF5F7B4619E1CCFCC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1J9A0A0R4J1J9_MOUSE
Tomoregulin-2
Tmeff2
262Annotation score:

Sequence cautioni

The sequence BAA95049 differs from that shown. Reason: Frameshift at position 209.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014314147 – 262VHEGS…AREHH → EKFSKVMLILKPCTASSLEE TNSKEIILCNPSNTHLLKKN ENANLTCWSEPFLQAYGLMR TWNSRQREAAKGITETRFLP PPSAYCLGIFIGANVKINSE ALFRQWTVLKGTIPVP in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017270 mRNA Translation: BAA87898.1
AB041565 mRNA Translation: BAA95049.1 Frameshift.
AK029307 mRNA Translation: BAC26385.1
AK030053 mRNA Translation: BAC26760.1
AK076254 mRNA Translation: BAC36276.1
AK135038 mRNA Translation: BAE22393.1
BC034850 mRNA Translation: AAH34850.1
CCDSiCCDS14939.1 [Q9QYM9-1]
RefSeqiNP_062764.1, NM_019790.4 [Q9QYM9-1]
UniGeneiMm.245154
Mm.445120

Genome annotation databases

EnsembliENSMUST00000081851; ENSMUSP00000080533; ENSMUSG00000026109 [Q9QYM9-1]
GeneIDi56363
KEGGimmu:56363
UCSCiuc007axj.1 mouse [Q9QYM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017270 mRNA Translation: BAA87898.1
AB041565 mRNA Translation: BAA95049.1 Frameshift.
AK029307 mRNA Translation: BAC26385.1
AK030053 mRNA Translation: BAC26760.1
AK076254 mRNA Translation: BAC36276.1
AK135038 mRNA Translation: BAE22393.1
BC034850 mRNA Translation: AAH34850.1
CCDSiCCDS14939.1 [Q9QYM9-1]
RefSeqiNP_062764.1, NM_019790.4 [Q9QYM9-1]
UniGeneiMm.245154
Mm.445120

3D structure databases

ProteinModelPortaliQ9QYM9
SMRiQ9QYM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QYM9, 1 interactor
STRINGi10090.ENSMUSP00000080533

Protein family/group databases

MEROPSiI01.969

PTM databases

PhosphoSitePlusiQ9QYM9

Proteomic databases

PaxDbiQ9QYM9
PeptideAtlasiQ9QYM9
PRIDEiQ9QYM9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081851; ENSMUSP00000080533; ENSMUSG00000026109 [Q9QYM9-1]
GeneIDi56363
KEGGimmu:56363
UCSCiuc007axj.1 mouse [Q9QYM9-1]

Organism-specific databases

CTDi23671
MGIiMGI:1861735 Tmeff2

Phylogenomic databases

eggNOGiENOG410IP0A Eukaryota
ENOG4110TEU LUCA
GeneTreeiENSGT00730000110884
HOGENOMiHOG000154541
HOVERGENiHBG053816
InParanoidiQ9QYM9
OMAiNCSGFDD
OrthoDBiEOG091G0AKU
PhylomeDBiQ9QYM9
TreeFamiTF330868

Miscellaneous databases

PROiPR:Q9QYM9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026109 Expressed in 213 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiQ9QYM9 baseline and differential
GenevisibleiQ9QYM9 MM

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS51465 KAZAL_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTEFF2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYM9
Secondary accession number(s): Q3UY20, Q8CDH1, Q9JJE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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