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Protein

Centromere protein H

Gene

Cenph

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity).By similarity

GO - Molecular functioni

  • kinetochore binding Source: UniProtKB

GO - Biological processi

  • chromosome segregation Source: MGI
  • kinetochore assembly Source: InterPro
  • kinetochore organization Source: UniProtKB
  • mitotic cell cycle Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein H
Short name:
CENP-H
Gene namesi
Name:CenphImported
Synonyms:EnpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349448 Cenph

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894791 – 241Centromere protein HAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei62PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9QYM8
MaxQBiQ9QYM8
PaxDbiQ9QYM8
PeptideAtlasiQ9QYM8
PRIDEiQ9QYM8

PTM databases

PhosphoSitePlusiQ9QYM8

Expressioni

Tissue specificityi

Abundantly expressed in thymus, spleen, uterus, ovary, testis and muscle, and weakly expressed in small intestine, lung and stomach. Barely detectable expression in kidney, liver, skin and prostate gland. Not detected in brain, heart or adrenal gland. Also expressed weakly in various hematopoietic cell lines.1 Publication

Developmental stagei

Abundantly expressed between embryonic day 9.5 and 12.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000045273 Expressed in 172 organ(s), highest expression level in dorsal pancreas
CleanExiMM_CENPH
GenevisibleiQ9QYM8 MM

Interactioni

Subunit structurei

Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS (By similarity). Interacts directly with CENPK (By similarity). Interacts with KIF2C and NDC80 (By similarity). Interacts with TRIM36.By similarity1 Publication

Protein-protein interaction databases

BioGridi205039, 25 interactors
IntActiQ9QYM8, 25 interactors
STRINGi10090.ENSMUSP00000074988

Structurei

3D structure databases

ProteinModelPortaliQ9QYM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 186Sequence analysisAdd BLAST159

Sequence similaritiesi

Belongs to the CENP-H/MCM16 family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9S Eukaryota
ENOG410Y6WK LUCA
GeneTreeiENSGT00390000009578
HOGENOMiHOG000013068
HOVERGENiHBG081083
InParanoidiQ9QYM8
KOiK11500
OMAiKSMIDAN
OrthoDBiEOG091G1AJR
PhylomeDBiQ9QYM8
TreeFamiTF101134

Family and domain databases

InterProiView protein in InterPro
IPR040034 CENP-H
IPR008426 CENP-H_C
PANTHERiPTHR28662 PTHR28662, 1 hit
PfamiView protein in Pfam
PF05837 CENP-H, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QYM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEQPRERSE AGAEACEEKR GLSQAAEERI EDRISLLLRL RAQTKQQLLE
60 70 80 90 100
YKSMIDTNEE KTPEQIMQEK QIEVKIEELE NEIEDVKSNI EMKSLALSRM
110 120 130 140 150
KLSVALRDNM ENMGPENCVL TDDMKHILKL QKLIMKSQEE SSELEKKLLD
160 170 180 190 200
VRKKRLQLKQ ASRSKLLEIQ IEKNKQKEDV DKMENSEMIK TMKKKLQTEI
210 220 230 240
KITTVVQHTF QGLILASKTN WAEDPALRET VLQLEKDLNT L
Length:241
Mass (Da):28,135
Last modified:May 1, 2000 - v1
Checksum:iA56CD10AFE07D0AD
GO

Sequence cautioni

The sequence BAB27505 differs from that shown. Reason: Frameshift at position 195.Curated
The sequence BAB27810 differs from that shown. Reason: Frameshift at position 195.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239N → T in AAH25084 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017634 mRNA Translation: BAA88520.1
AK011264 mRNA Translation: BAB27505.1 Frameshift.
AK011738 mRNA Translation: BAB27810.1 Frameshift.
BC025084 mRNA Translation: AAH25084.1
CCDSiCCDS26738.1
RefSeqiNP_068686.1, NM_021886.1
UniGeneiMm.273502

Genome annotation databases

EnsembliENSMUST00000075550; ENSMUSP00000074988; ENSMUSG00000045273
GeneIDi26886
KEGGimmu:26886
UCSCiuc007rrn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017634 mRNA Translation: BAA88520.1
AK011264 mRNA Translation: BAB27505.1 Frameshift.
AK011738 mRNA Translation: BAB27810.1 Frameshift.
BC025084 mRNA Translation: AAH25084.1
CCDSiCCDS26738.1
RefSeqiNP_068686.1, NM_021886.1
UniGeneiMm.273502

3D structure databases

ProteinModelPortaliQ9QYM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205039, 25 interactors
IntActiQ9QYM8, 25 interactors
STRINGi10090.ENSMUSP00000074988

PTM databases

PhosphoSitePlusiQ9QYM8

Proteomic databases

EPDiQ9QYM8
MaxQBiQ9QYM8
PaxDbiQ9QYM8
PeptideAtlasiQ9QYM8
PRIDEiQ9QYM8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075550; ENSMUSP00000074988; ENSMUSG00000045273
GeneIDi26886
KEGGimmu:26886
UCSCiuc007rrn.1 mouse

Organism-specific databases

CTDi64946
MGIiMGI:1349448 Cenph

Phylogenomic databases

eggNOGiENOG410IG9S Eukaryota
ENOG410Y6WK LUCA
GeneTreeiENSGT00390000009578
HOGENOMiHOG000013068
HOVERGENiHBG081083
InParanoidiQ9QYM8
KOiK11500
OMAiKSMIDAN
OrthoDBiEOG091G1AJR
PhylomeDBiQ9QYM8
TreeFamiTF101134

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

PROiPR:Q9QYM8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045273 Expressed in 172 organ(s), highest expression level in dorsal pancreas
CleanExiMM_CENPH
GenevisibleiQ9QYM8 MM

Family and domain databases

InterProiView protein in InterPro
IPR040034 CENP-H
IPR008426 CENP-H_C
PANTHERiPTHR28662 PTHR28662, 1 hit
PfamiView protein in Pfam
PF05837 CENP-H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPH_MOUSE
AccessioniPrimary (citable) accession number: Q9QYM8
Secondary accession number(s): Q8R3K9, Q9D079, Q9D0N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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