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Protein

RING finger protein 11

Gene

Rnf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 140RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • protein autoubiquitination Source: MGI
  • ubiquitin-dependent protein catabolic process Source: MGI

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 11
Alternative name(s):
NEDD4 WW domain-binding protein 2
Sid 1669
Gene namesi
Name:Rnf11
Synonyms:N4wbp2, Sid1669
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1352759 Rnf11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40Y → A: Abolishes interaction with NEDD4. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000560512 – 154RING finger protein 11Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi4S-palmitoyl cysteineBy similarity1
Modified residuei14PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei135Phosphothreonine; by PKB/AKT1By similarity1

Post-translational modificationi

Ubiquitinated in the presence of ITCH, SMURF2 and UBE2D1, as well as WWP1.By similarity
Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome.By similarity
Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9QYK7
PaxDbiQ9QYK7
PeptideAtlasiQ9QYK7
PRIDEiQ9QYK7

PTM databases

iPTMnetiQ9QYK7
PhosphoSitePlusiQ9QYK7
SwissPalmiQ9QYK7

Expressioni

Gene expression databases

BgeeiENSMUSG00000028557 Expressed in 318 organ(s), highest expression level in blood
CleanExiMM_RNF11
ExpressionAtlasiQ9QYK7 baseline and differential
GenevisibleiQ9QYK7 MM

Interactioni

Subunit structurei

Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP (By similarity). After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with GGA1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Nedd4P469354EBI-4405826,EBI-773516

Protein-protein interaction databases

BioGridi205930, 9 interactors
IntActiQ9QYK7, 8 interactors
MINTiQ9QYK7
STRINGi10090.ENSMUSP00000030284

Structurei

3D structure databases

ProteinModelPortaliQ9QYK7
SMRiQ9QYK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 40PPxY motif4

Domaini

The PPxY motif mediates interaction with NEDD4.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 140RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00730000110988
HOGENOMiHOG000007448
HOVERGENiHBG058444
InParanoidiQ9QYK7
KOiK11980
OMAiHLDCIDN
OrthoDBiEOG091G0T50
PhylomeDBiQ9QYK7
TreeFamiTF318022

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QYK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNCLKSPTS DDISLLHESQ SDRASFGEGT EPDQEPPPPY QEQVPVPIYH
60 70 80 90 100
PTPSQTRLAT QLTEEEQIRI AQRIGLIQHL PKGVYDPGRD GSEKKIRECV
110 120 130 140 150
ICMMDFVYGD PIRFLPCMHI YHLDCIDDWL MRSFTCPSCM EPVDAALLSS

YETN
Length:154
Mass (Da):17,458
Last modified:May 1, 2000 - v1
Checksum:iEF192AB0C2D4BF87
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YLT8Z4YLT8_MOUSE
RING finger protein 11
Rnf11
144Annotation score:

Sequence cautioni

The sequence AAG44245 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024427 mRNA Translation: BAA84682.1
AF220206 mRNA Translation: AAG44245.1 Different initiation.
AL669905 Genomic DNA Translation: CAM13662.1
AL669905 Genomic DNA Translation: CAM13663.1
CH466527 Genomic DNA Translation: EDL30703.1
CH466527 Genomic DNA Translation: EDL30704.1
CH466527 Genomic DNA Translation: EDL30705.1
BC010299 mRNA Translation: AAH10299.1
BC028255 mRNA Translation: AAH28255.1
CCDSiCCDS18464.1
RefSeqiNP_038904.1, NM_013876.3
UniGeneiMm.392580
Mm.456388

Genome annotation databases

EnsembliENSMUST00000030284; ENSMUSP00000030284; ENSMUSG00000028557
ENSMUST00000064167; ENSMUSP00000063798; ENSMUSG00000028557
GeneIDi29864
KEGGimmu:29864
UCSCiuc008ucm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024427 mRNA Translation: BAA84682.1
AF220206 mRNA Translation: AAG44245.1 Different initiation.
AL669905 Genomic DNA Translation: CAM13662.1
AL669905 Genomic DNA Translation: CAM13663.1
CH466527 Genomic DNA Translation: EDL30703.1
CH466527 Genomic DNA Translation: EDL30704.1
CH466527 Genomic DNA Translation: EDL30705.1
BC010299 mRNA Translation: AAH10299.1
BC028255 mRNA Translation: AAH28255.1
CCDSiCCDS18464.1
RefSeqiNP_038904.1, NM_013876.3
UniGeneiMm.392580
Mm.456388

3D structure databases

ProteinModelPortaliQ9QYK7
SMRiQ9QYK7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205930, 9 interactors
IntActiQ9QYK7, 8 interactors
MINTiQ9QYK7
STRINGi10090.ENSMUSP00000030284

PTM databases

iPTMnetiQ9QYK7
PhosphoSitePlusiQ9QYK7
SwissPalmiQ9QYK7

Proteomic databases

MaxQBiQ9QYK7
PaxDbiQ9QYK7
PeptideAtlasiQ9QYK7
PRIDEiQ9QYK7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030284; ENSMUSP00000030284; ENSMUSG00000028557
ENSMUST00000064167; ENSMUSP00000063798; ENSMUSG00000028557
GeneIDi29864
KEGGimmu:29864
UCSCiuc008ucm.1 mouse

Organism-specific databases

CTDi26994
MGIiMGI:1352759 Rnf11

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00730000110988
HOGENOMiHOG000007448
HOVERGENiHBG058444
InParanoidiQ9QYK7
KOiK11980
OMAiHLDCIDN
OrthoDBiEOG091G0T50
PhylomeDBiQ9QYK7
TreeFamiTF318022

Miscellaneous databases

ChiTaRSiRnf11 mouse
PROiPR:Q9QYK7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028557 Expressed in 318 organ(s), highest expression level in blood
CleanExiMM_RNF11
ExpressionAtlasiQ9QYK7 baseline and differential
GenevisibleiQ9QYK7 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNF11_MOUSE
AccessioniPrimary (citable) accession number: Q9QYK7
Secondary accession number(s): B1AU36, B1AU37, Q9EQI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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