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Protein

DnaJ homolog subfamily B member 1

Gene

Dnajb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-3371568 Attenuation phase
R-MMU-3371571 HSF1-dependent transactivation
R-MMU-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 1
Alternative name(s):
Heat shock 40 kDa protein 1
Short name:
HSP40
Short name:
Heat shock protein 40
Gene namesi
Name:Dnajb1
Synonyms:Hsp40, Hspf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1931874 Dnajb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710171 – 340DnaJ homolog subfamily B member 1Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QYJ3
MaxQBiQ9QYJ3
PaxDbiQ9QYJ3
PRIDEiQ9QYJ3

PTM databases

iPTMnetiQ9QYJ3
PhosphoSitePlusiQ9QYJ3

Expressioni

Inductioni

By heat shock.By similarity

Gene expression databases

BgeeiENSMUSG00000005483
CleanExiMM_DNAJB1
ExpressionAtlasiQ9QYJ3 baseline and differential
GenevisibleiQ9QYJ3 MM

Interactioni

Subunit structurei

Interacts with DNAJC3. Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219875, 1 interactor
IntActiQ9QYJ3, 2 interactors
MINTiQ9QYJ3
STRINGi10090.ENSMUSP00000005620

Structurei

3D structure databases

ProteinModelPortaliQ9QYJ3
SMRiQ9QYJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 70JPROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00760000118947
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiQ9QYJ3
KOiK09507
OMAiGAYTYQF
OrthoDBiEOG091G0DLS
PhylomeDBiQ9QYJ3
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QYJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDYYQTLG LARGASDDEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE
60 70 80 90 100
AYDVLSDPRK REIFDRYGEE GLKGGSPSGG SSGGANGTSF SYTFHGDPHA
110 120 130 140 150
MFAEFFGGRN PFDTFFGQRN GEEGMDIDDT FSSFPMGMGG FTNMNFGRSR
160 170 180 190 200
PSQEPTRKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE
210 220 230 240 250
DKILTIEVKR GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD
260 270 280 290 300
GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE
310 320 330 340
GLPLPKTPEK RGDLVIEFEV IFPERIPVSS RTILEQVLPI
Length:340
Mass (Da):38,167
Last modified:January 23, 2007 - v3
Checksum:iF775BFBA4A5D324E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028272 mRNA Translation: BAA88083.1
AB028273 Genomic DNA Translation: BAA95672.1
BC012962 mRNA Translation: AAH12962.1
CCDSiCCDS22456.1
RefSeqiNP_061278.1, NM_018808.3
UniGeneiMm.282092
Mm.420989
Mm.478920

Genome annotation databases

EnsembliENSMUST00000005620; ENSMUSP00000005620; ENSMUSG00000005483
GeneIDi81489
KEGGimmu:81489
UCSCiuc009mkp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDNJB1_MOUSE
AccessioniPrimary (citable) accession number: Q9QYJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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