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Protein

Ras GTPase-activating protein 3

Gene

Rasa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri679 – 715Btk-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 3
Alternative name(s):
GAP1(IP4BP)
Ins P4-binding protein
R-ras GAP
Gene namesi
Name:Rasa3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69365 Rasa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000566442 – 834Ras GTPase-activating protein 3Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei66PhosphotyrosineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei110PhosphothreonineBy similarity1
Modified residuei809PhosphoserineCombined sources1
Modified residuei833PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QYJ2
PRIDEiQ9QYJ2

PTM databases

iPTMnetiQ9QYJ2
PhosphoSitePlusiQ9QYJ2

Interactioni

Protein-protein interaction databases

BioGridi248025, 2 interactors
STRINGi10116.ENSRNOP00000061587

Structurei

3D structure databases

ProteinModelPortaliQ9QYJ2
SMRiQ9QYJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 96C2 1PROSITE-ProRule annotationAdd BLAST96
Domaini132 – 247C2 2PROSITE-ProRule annotationAdd BLAST116
Domaini330 – 524Ras-GAPPROSITE-ProRule annotationAdd BLAST195
Domaini576 – 677PHPROSITE-ProRule annotationAdd BLAST102

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri679 – 715Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2059 Eukaryota
ENOG410Y128 LUCA
HOGENOMiHOG000007183
HOVERGENiHBG055643
InParanoidiQ9QYJ2
KOiK12380
PhylomeDBiQ9QYJ2

Family and domain databases

CDDicd13371 PH_GAP1_mammal-like, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR037774 RASA3_PH
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif
PANTHERiPTHR10194 PTHR10194, 1 hit
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 2 hits
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVEEEGLRV FQSVRIKIGE AKNLPSYPGP NKMRDCYCTV NLDQEEVFRT
60 70 80 90 100
KIVEKSLCPF YGEDFYCEIP RSFRHLSFYI FDRDVFRRDS IIGKVAIQKE
110 120 130 140 150
DLQRYHNRDT WFQLQHVDAD SEVQGKVHLE LRLSEVITDT GVVCHKLAAR
160 170 180 190 200
IFECQGLPIV NGQCDPYATV TLAGPFRSEA KKTKVKKKTN NPQFDEVFYF
210 220 230 240 250
EVTRPCSYSK KSHFDFEEED VDKLEIRVDL WNASNLKFGD EFLGELRIPL
260 270 280 290 300
HVLRYASSYE AWYFLQPRDN GSKSVKPDDL GSLRLNVVYT EDHVFSSEYY
310 320 330 340 350
SPLRDLLLKS ADVEPVSASA AHILGEVCRD KQEAAIPLVR LLLHYGRVVP
360 370 380 390 400
FISAIASAEV KRTQDPNTIF RGNSLTSKCI DETMKLAGMH YLHVTLKPTI
410 420 430 440 450
EEICQSHKSC EIDPVKLKDG ENLENNMESL RQYVDRIFSV ITKSGVSCPT
460 470 480 490 500
VMCDIFFSLR EAAAKRFQDD LDVRYTAVSS FIFLRFFAPA ILSPNLFQLT
510 520 530 540 550
PHHTDPQTSR TLTLISKTIQ TLGSLSKSKS ASFKESYMAT FYEFFNEQKY
560 570 580 590 600
ADAVKNFLDL ISSSGRRDPK SIEQPILLKE GFMIKRAQGR KRFGMKNFKK
610 620 630 640 650
RWFRLTNHEF TYQKSKGDQP LCNIPIENIL AVERLEEESF RMKNMFQVIQ
660 670 680 690 700
PERALYIQAN NCVEAKDWID ILTKVSQCNQ KRLTVFHPSA YLNGHWLCCR
710 720 730 740 750
ASSDTAIGCT PCTGGLPANI QLDIDGDRET ERIYSLFNLY MGKLEKMQEA
760 770 780 790 800
CGSKSVYDGP EQEEYSTFII DDPQETYRTL KQVIAGVGTL EQEHAQYRRN
810 820 830
KFKKTRYGSQ EHPIGDKSFQ NYIRQQSEIS THSI
Length:834
Mass (Da):96,020
Last modified:November 28, 2006 - v2
Checksum:i04F9B79A3C2F946F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti778R → K in BAA89032 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86045 mRNA Translation: BAF31891.1
AB028626 mRNA Translation: BAA89032.1
RefSeqiNP_113762.1, NM_031574.1
UniGeneiRn.224604

Genome annotation databases

GeneIDi29372
KEGGirno:29372

Similar proteinsi

Entry informationi

Entry nameiRASA3_RAT
AccessioniPrimary (citable) accession number: Q9QYJ2
Secondary accession number(s): Q09YN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 28, 2006
Last modified: July 18, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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