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Protein

DnaJ homolog subfamily A member 2

Gene

Dnaja2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Zinc 1By similarity1
Metal bindingi146Zinc 1By similarity1
Metal bindingi159Zinc 2By similarity1
Metal bindingi162Zinc 2By similarity1
Metal bindingi186Zinc 2By similarity1
Metal bindingi189Zinc 2By similarity1
Metal bindingi202Zinc 1By similarity1
Metal bindingi205Zinc 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 2
Alternative name(s):
mDj3
Gene namesi
Name:Dnaja2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1931882 Dnaja2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710121 – 409DnaJ homolog subfamily A member 2Add BLAST409
PropeptideiPRO_0000396758410 – 412Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineCombined sources1
Modified residuei78PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei152N6-acetyllysineCombined sources1
Modified residuei391PhosphotyrosineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei409Cysteine methyl esterBy similarity1
Lipidationi409S-farnesyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Methylation, Phosphoprotein, Prenylation, Ubl conjugation

Proteomic databases

EPDiQ9QYJ0
MaxQBiQ9QYJ0
PaxDbiQ9QYJ0
PeptideAtlasiQ9QYJ0
PRIDEiQ9QYJ0

PTM databases

iPTMnetiQ9QYJ0
PhosphoSitePlusiQ9QYJ0
SwissPalmiQ9QYJ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000031701 Expressed in 298 organ(s), highest expression level in ear
CleanExiMM_DNAJA2
GenevisibleiQ9QYJ0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207986, 6 interactors
IntActiQ9QYJ0, 10 interactors
MINTiQ9QYJ0
STRINGi10090.ENSMUSP00000034138

Structurei

3D structure databases

ProteinModelPortaliQ9QYJ0
SMRiQ9QYJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 70JAdd BLAST63
Repeati143 – 150CXXCXGXG motif8
Repeati159 – 166CXXCXGXG motif8
Repeati186 – 193CXXCXGXG motif8
Repeati202 – 209CXXCXGXG motif8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 214CR-typeAdd BLAST85

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0712 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133716
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiQ9QYJ0
KOiK09503
OMAiNALCTKC
OrthoDBiEOG091G0CAC
PhylomeDBiQ9QYJ0
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd10719 DnaJ_zf, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01152 DnaJ, 1 hit
InterProiView protein in InterPro
IPR012724 DnaJ
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR001305 HSP_DnaJ_Cys-rich_dom
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
SSF57938 SSF57938, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51188 ZF_CR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QYJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI
60 70 80 90 100
SFAYEVLSNP EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM
110 120 130 140 150
GNQSRSRNGR RRGEDMMHPL KVSLEDLYNG KTTKLQLSKN VLCSACSGQG
160 170 180 190 200
GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ QMQSVCSDCN GEGEVINEKD
210 220 230 240 250
RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA PGVEPGDIVL
260 270 280 290 300
LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD ARQIVVKYPP
310 320 330 340 350
GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE
360 370 380 390 400
LEDLLPSRPE VPNVIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS
410
SHHGPGVQCA HQ
Length:412
Mass (Da):45,746
Last modified:May 1, 2000 - v1
Checksum:i98130EC0925CB42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028853 mRNA Translation: BAA88301.1
AK077672 mRNA Translation: BAC36946.1
AK083208 mRNA Translation: BAC38809.1
BC003420 mRNA Translation: AAH03420.1
CCDSiCCDS22500.1
RefSeqiNP_062768.1, NM_019794.4
UniGeneiMm.475573

Genome annotation databases

EnsembliENSMUST00000034138; ENSMUSP00000034138; ENSMUSG00000031701
GeneIDi56445
KEGGimmu:56445
UCSCiuc009mqa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028853 mRNA Translation: BAA88301.1
AK077672 mRNA Translation: BAC36946.1
AK083208 mRNA Translation: BAC38809.1
BC003420 mRNA Translation: AAH03420.1
CCDSiCCDS22500.1
RefSeqiNP_062768.1, NM_019794.4
UniGeneiMm.475573

3D structure databases

ProteinModelPortaliQ9QYJ0
SMRiQ9QYJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207986, 6 interactors
IntActiQ9QYJ0, 10 interactors
MINTiQ9QYJ0
STRINGi10090.ENSMUSP00000034138

PTM databases

iPTMnetiQ9QYJ0
PhosphoSitePlusiQ9QYJ0
SwissPalmiQ9QYJ0

Proteomic databases

EPDiQ9QYJ0
MaxQBiQ9QYJ0
PaxDbiQ9QYJ0
PeptideAtlasiQ9QYJ0
PRIDEiQ9QYJ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034138; ENSMUSP00000034138; ENSMUSG00000031701
GeneIDi56445
KEGGimmu:56445
UCSCiuc009mqa.1 mouse

Organism-specific databases

CTDi10294
MGIiMGI:1931882 Dnaja2

Phylogenomic databases

eggNOGiKOG0712 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133716
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiQ9QYJ0
KOiK09503
OMAiNALCTKC
OrthoDBiEOG091G0CAC
PhylomeDBiQ9QYJ0
TreeFamiTF105141

Enzyme and pathway databases

ReactomeiR-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Miscellaneous databases

ChiTaRSiDnaja2 mouse
PROiPR:Q9QYJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031701 Expressed in 298 organ(s), highest expression level in ear
CleanExiMM_DNAJA2
GenevisibleiQ9QYJ0 MM

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd10719 DnaJ_zf, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01152 DnaJ, 1 hit
InterProiView protein in InterPro
IPR012724 DnaJ
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR001305 HSP_DnaJ_Cys-rich_dom
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
SSF57938 SSF57938, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51188 ZF_CR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNJA2_MOUSE
AccessioniPrimary (citable) accession number: Q9QYJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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