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Protein

DnaJ homolog subfamily C member 7

Gene

Dnajc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 7
Alternative name(s):
Cytoplasmic CAR retention protein
Short name:
CCRP
MDj11
Tetratricopeptide repeat protein 2
Short name:
TPR repeat protein 2
Gene namesi
Name:Dnajc7
Synonyms:Ttc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1928373 Dnajc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000710592 – 494DnaJ homolog subfamily C member 7Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei393PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9QYI3
MaxQBiQ9QYI3
PaxDbiQ9QYI3
PRIDEiQ9QYI3

2D gel databases

REPRODUCTION-2DPAGEiQ9QYI3

PTM databases

iPTMnetiQ9QYI3
PhosphoSitePlusiQ9QYI3

Expressioni

Tissue specificityi

Widely expressed with high levels in liver, skeletal muscle, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000014195 Expressed in 293 organ(s), highest expression level in bone marrow
CleanExiMM_DNAJC7
ExpressionAtlasiQ9QYI3 baseline and differential
GenevisibleiQ9QYI3 MM

Interactioni

Subunit structurei

Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1 (By similarity). Interacts with NR1I3; this complex may also include HSP90 Interacts with HSPA8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207919, 4 interactors
IntActiQ9QYI3, 1 interactor
STRINGi10090.ENSMUSP00000014339

Structurei

3D structure databases

ProteinModelPortaliQ9QYI3
SMRiQ9QYI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 61TPR 1Add BLAST34
Repeati62 – 95TPR 2Add BLAST34
Repeati96 – 129TPR 3Add BLAST34
Repeati142 – 175TPR 4Add BLAST34
Repeati210 – 243TPR 5Add BLAST34
Repeati256 – 289TPR 6Add BLAST34
Repeati294 – 327TPR 7Add BLAST34
Repeati328 – 361TPR 8Add BLAST34
Domaini381 – 451JPROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0550 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00890000139418
HOVERGENiHBG051376
InParanoidiQ9QYI3
KOiK09527
OMAiPRKWQLM
OrthoDBiEOG091G0898
PhylomeDBiQ9QYI3
TreeFamiTF105166

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF13181 TPR_8, 2 hits
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00028 TPR, 8 hits
SUPFAMiSSF46565 SSF46565, 1 hit
SSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QYI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATAECDVV MAATEPELLE DEDAKREAES FKEQGNAYYA KKDYNEAYNY
60 70 80 90 100
YTKAIDMCPN NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL
110 120 130 140 150
REGKCHLSLG NAMAACRSFQ RALELDHKNA QAQQEFKNAN AVMEYEKIAE
160 170 180 190 200
VDFEKRDFRK VVFCMDRALE FAPACHRFKI LKAECLAMLG RYPEAQFVAS
210 220 230 240 250
DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA PDHEKACVAC
260 270 280 290 300
RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR
310 320 330 340 350
GTVNSKLRQL EDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQFEEAVRD
360 370 380 390 400
YEKVYQTEKT KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA
410 420 430 440 450
YRKRALMHHP DRHSGASAEV QKEEEKKFKE VGEAFTILSD PKKKTRYDSG
460 470 480 490
QDLDEEGMNM GDFDANNIFK AFFGGPGGFS FEASGPGNFY FQFG
Length:494
Mass (Da):56,476
Last modified:April 13, 2004 - v2
Checksum:i8D82EBFA19C556B9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A5E1A2A5E1_MOUSE
DnaJ homolog subfamily C member 7
Dnajc7
147Annotation score:
F7BTP8F7BTP8_MOUSE
DnaJ homolog subfamily C member 7
Dnajc7
259Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86 – 87QQ → HE in BAB27893 (PubMed:16141072).Curated2
Sequence conflicti118S → I in BAA88309 (PubMed:11147971).Curated1
Sequence conflicti136F → L in AAQ91291 (PubMed:14573755).Curated1
Sequence conflicti192Y → F in BAC36133 (PubMed:16141072).Curated1
Sequence conflicti285I → V in BAB27893 (PubMed:16141072).Curated1
Sequence conflicti489F → L in BAA88309 (PubMed:11147971).Curated1
Sequence conflicti489F → L in AAQ91291 (PubMed:14573755).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028861 mRNA Translation: BAA88309.1
AK011384 mRNA Translation: BAB27584.1
AK011875 mRNA Translation: BAB27893.1
AK076032 mRNA Translation: BAC36133.1
AK145506 mRNA Translation: BAE26476.1
AK166872 mRNA Translation: BAE39083.1
AY323828 mRNA Translation: AAQ91291.1
BC023681 mRNA Translation: AAH23681.1
BC055729 mRNA Translation: AAH55729.1
CCDSiCCDS25428.1
RefSeqiNP_062769.2, NM_019795.4
UniGeneiMm.402409

Genome annotation databases

EnsembliENSMUST00000014339; ENSMUSP00000014339; ENSMUSG00000014195
GeneIDi56354
KEGGimmu:56354
UCSCiuc007lls.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028861 mRNA Translation: BAA88309.1
AK011384 mRNA Translation: BAB27584.1
AK011875 mRNA Translation: BAB27893.1
AK076032 mRNA Translation: BAC36133.1
AK145506 mRNA Translation: BAE26476.1
AK166872 mRNA Translation: BAE39083.1
AY323828 mRNA Translation: AAQ91291.1
BC023681 mRNA Translation: AAH23681.1
BC055729 mRNA Translation: AAH55729.1
CCDSiCCDS25428.1
RefSeqiNP_062769.2, NM_019795.4
UniGeneiMm.402409

3D structure databases

ProteinModelPortaliQ9QYI3
SMRiQ9QYI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207919, 4 interactors
IntActiQ9QYI3, 1 interactor
STRINGi10090.ENSMUSP00000014339

PTM databases

iPTMnetiQ9QYI3
PhosphoSitePlusiQ9QYI3

2D gel databases

REPRODUCTION-2DPAGEiQ9QYI3

Proteomic databases

EPDiQ9QYI3
MaxQBiQ9QYI3
PaxDbiQ9QYI3
PRIDEiQ9QYI3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014339; ENSMUSP00000014339; ENSMUSG00000014195
GeneIDi56354
KEGGimmu:56354
UCSCiuc007lls.1 mouse

Organism-specific databases

CTDi7266
MGIiMGI:1928373 Dnajc7

Phylogenomic databases

eggNOGiKOG0550 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00890000139418
HOVERGENiHBG051376
InParanoidiQ9QYI3
KOiK09527
OMAiPRKWQLM
OrthoDBiEOG091G0898
PhylomeDBiQ9QYI3
TreeFamiTF105166

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRSiDnajc7 mouse
PROiPR:Q9QYI3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014195 Expressed in 293 organ(s), highest expression level in bone marrow
CleanExiMM_DNAJC7
ExpressionAtlasiQ9QYI3 baseline and differential
GenevisibleiQ9QYI3 MM

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF13181 TPR_8, 2 hits
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00028 TPR, 8 hits
SUPFAMiSSF46565 SSF46565, 1 hit
SSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNJC7_MOUSE
AccessioniPrimary (citable) accession number: Q9QYI3
Secondary accession number(s): Q3TKR1
, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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