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Protein

Unconventional myosin-Va

Gene

Myo5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi163 – 170ATPSequence analysis8

GO - Molecular functioni

  • actin filament binding Source: InterPro
  • ATP binding Source: RGD
  • ATP-dependent protein binding Source: RGD
  • calcium-dependent protein binding Source: RGD
  • calmodulin binding Source: UniProtKB-KW
  • microfilament motor activity Source: RGD
  • motor activity Source: RGD
  • protein dimerization activity Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • SNARE binding Source: RGD
  • syntaxin-1 binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Va
Alternative name(s):
Dilute myosin heavy chain, non-muscle
Gene namesi
Name:Myo5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3143 Myo5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Defects in Myo5a are a cause of Dilute-opisthotonus (dop). Dop rats have diluted coat color and are occasionally associated with severe neurological disorders.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001234582 – 1828Unconventional myosin-VaAdd BLAST1827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei600PhosphoserineCombined sources1
Modified residuei1032PhosphothreonineCombined sources1
Modified residuei1425PhosphoserineCombined sources1
Modified residuei1625PhosphoserineCombined sources1
Modified residuei1733PhosphothreonineSequence analysis1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9QYF3

PTM databases

iPTMnetiQ9QYF3
PhosphoSitePlusiQ9QYF3

Interactioni

Subunit structurei

May be a homodimer, which associates with multiple calmodulin or myosin light chains (By similarity). Interacts with RIPL2, the interaction is required for its role in dendrite formation (PubMed:19812310). Interacts with MLPH. Interacts with SYTL4 (By similarity). Interacts with MYRIP (By similarity). Interacts with RAB10; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (By similarity). Interacts with FMR1; this interaction occurs in association with polyribosome (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247098, 2 interactors
IntActiQ9QYF3, 2 interactors
MINTiQ9QYF3

Structurei

3D structure databases

ProteinModelPortaliQ9QYF3
SMRiQ9QYF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 60Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST53
Domaini69 – 763Myosin motorPROSITE-ProRule annotationAdd BLAST695
Domaini766 – 788IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini789 – 813IQ 2PROSITE-ProRule annotationAdd BLAST25
Domaini814 – 836IQ 3PROSITE-ProRule annotationAdd BLAST23
Domaini837 – 861IQ 4PROSITE-ProRule annotationAdd BLAST25
Domaini862 – 884IQ 5PROSITE-ProRule annotationAdd BLAST23
Domaini885 – 914IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini1507 – 1783DilutePROSITE-ProRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni643 – 665Actin-bindingSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili914 – 1239Sequence analysisAdd BLAST326
Coiled coili1314 – 1418Sequence analysisAdd BLAST105

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG052556
InParanoidiQ9QYF3
KOiK10357
PhylomeDBiQ9QYF3

Family and domain databases

CDDicd15478 Myo5a_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037988 Myo5a_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 6 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9QYF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASELYTKF ARVWIPDPEE VWKSAELLKD YKPGDKVLLL HLEEGKDLEY
60 70 80 90 100
RLDPKTSELP HLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFIDSKLIY
110 120 130 140 150
TYCGIVLVAI NPYEQLPIYG EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM
160 170 180 190 200
ARDERNQSII VSGESGAGKT VSAKYAMRYF ATVSGSASEA NVEEKVLASN
210 220 230 240 250
PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR TYLLEKSRVV
260 270 280 290 300
FQAEEERNYH IFYQLCASAK LPEFKMLRLG NADSFHYTKQ GGSPMIEGVD
310 320 330 340 350
DAKEMAHTRQ ACTLLGISES YQMGIFRILA GILHLGNVGF ASRDSDSCTI
360 370 380 390 400
PPKHEPLIIF CDLMGVDYEE MCHWLCHRKL ATATETYIKP ISKLQATNAR
410 420 430 440 450
DALAKHIYAK LFNWIVGHVN QALHSAVKQH SFIGVLDIYG FETFEINSFE
460 470 480 490 500
QFCINYANEK LQQQFNMHVF KLEQEEYMKE QIPWTLIDFY DNQPCINLIE
510 520 530 540 550
SKLGILDLLD EECKMPKGTD DTWAQKLYNT HLNKCALFEK PRMSNKAFII
560 570 580 590 600
KHFADKVEYQ CEGFLEKNKD TVFEEQIKVL KSSKFKMLPE LFQDDEKAIS
610 620 630 640 650
PTSATSSGRT PLTRVPVKPT KGRPGQTAKE HKKTVGLQFR NSLHLLMETL
660 670 680 690 700
NATTPHYVRC IKPNDFKFPF TFDEKRAVQQ LRACGVLETI RISAAGFPSR
710 720 730 740 750
WTYQEFFSRY RVLMKQKDVL GDRKQTCQNV LEKLILDKDK YQFGKTKIFF
760 770 780 790 800
RAGQVAYLEK LRADKLRAAC IRIQKTIRGW LLRKRYLCMQ RAAITVQRYV
810 820 830 840 850
RGYQARCYAK FLRRTKAATT IQKYWRMYVV RRKYKIRRAA TIVLQSYLRG
860 870 880 890 900
YLARNRYRKI LREHKAVIIQ KRVRGWLART HYKRTMKAII YLQCCFRRMM
910 920 930 940 950
AKRELKKLKI EARSVERYKK LHIGMENKIM QLQRKVDEQN KDYKCLMEKL
960 970 980 990 1000
TNLEGVYNSE TEKLRNDVER LQLSEEEAKV ATGRVLSLQE EIAKLRKDLE
1010 1020 1030 1040 1050
QTRSEKKSIE ERADKYKQET EQLVSNLKEE NTLLKQEKET LNHLMVEQAK
1060 1070 1080 1090 1100
EMTETMERKL VEETKQLELD LNDERLRYQN LLNEFSRLEE RYDDLKEEMT
1110 1120 1130 1140 1150
LMLNVPKPGH KRTDSTHSSN ESEYTFSSEF AETEDIAPRT EEPTEKKVPL
1160 1170 1180 1190 1200
DMSLFLKLQK RVTELGQEKQ LMQDELDRKE EQVLRSKAKG GERPQIRGAE
1210 1220 1230 1240 1250
LGYESLKRQE LESENKKLKN ELNELRKALS EKSAPEVNAP GAPAYRVLME
1260 1270 1280 1290 1300
QLTAVSEELD VRKEEVLILR SQLVSQKEAI QPKDDKNTMT DSTILLEDVQ
1310 1320 1330 1340 1350
KMKDKGEIAQ AYIGLKETNR LLESQLQSQK RSHENEAEAL RGEIQSLKEE
1360 1370 1380 1390 1400
NNRQQQLLAQ NLQLPPEARI EASLQHEITR LTNENLDLME QLEKQDKTVR
1410 1420 1430 1440 1450
KLKKQLKVFA KKIGELEVGQ MENISPGQII DEPIRPVNIP RKGKDFQGML
1460 1470 1480 1490 1500
EYKREDEQKL VKNLILELKP RGVAVNLISG LPAYILFMCV RHADYLDDDQ
1510 1520 1530 1540 1550
KVRSLLTSTI NSIKKVLKKR GDDFETVSFW LSNTCRFLHC LKQYSGEEGF
1560 1570 1580 1590 1600
MKHNTSRQNE HCLTNFDLAE YRQVLSDLAI QIYQQLVRVL ENILQPMIVS
1610 1620 1630 1640 1650
GMLEHETIQG VSGVKPTGLR KRTSSIADEG TYTLDSILRQ LNSFHSVMCQ
1660 1670 1680 1690 1700
HGMDPELIKQ VVKQMFYIVG AITLNNLLLR KDMCSWSKGM QIRYNVSQLE
1710 1720 1730 1740 1750
EWLRDKNLMN SGAKETLEPL IQAAQLLQVK KKTDDDAEAI CSMCNALTTA
1760 1770 1780 1790 1800
QIVKVLNLYT PVNEFEERVS VSFIRTIQVR LRDRKDSPQL LMDAKHIFPV
1810 1820
TFPFNPSSLA LETIQIPASL GLGFIARV
Length:1,828
Mass (Da):211,764
Last modified:May 1, 2000 - v1
Checksum:i5B3DE1C89AE36123
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K4Y7A0A0G2K4Y7_RAT
Unconventional myosin-Va
Myo5a
1,828Annotation score:
A0A0G2K9X3A0A0G2K9X3_RAT
Unconventional myosin-Va
Myo5a
1,817Annotation score:
A0A0G2K9S4A0A0G2K9S4_RAT
Unconventional myosin-Va
Myo5a
1,746Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035736 mRNA Translation: BAA88350.1
RefSeqiNP_071514.1, NM_022178.1
UniGeneiRn.44865

Genome annotation databases

GeneIDi25017
KEGGirno:25017
UCSCiRGD:3143 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035736 mRNA Translation: BAA88350.1
RefSeqiNP_071514.1, NM_022178.1
UniGeneiRn.44865

3D structure databases

ProteinModelPortaliQ9QYF3
SMRiQ9QYF3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247098, 2 interactors
IntActiQ9QYF3, 2 interactors
MINTiQ9QYF3

PTM databases

iPTMnetiQ9QYF3
PhosphoSitePlusiQ9QYF3

Proteomic databases

PRIDEiQ9QYF3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25017
KEGGirno:25017
UCSCiRGD:3143 rat

Organism-specific databases

CTDi4644
RGDi3143 Myo5a

Phylogenomic databases

HOVERGENiHBG052556
InParanoidiQ9QYF3
KOiK10357
PhylomeDBiQ9QYF3

Miscellaneous databases

PROiPR:Q9QYF3

Family and domain databases

CDDicd15478 Myo5a_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037988 Myo5a_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 6 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO5A_RAT
AccessioniPrimary (citable) accession number: Q9QYF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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