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Entry version 169 (05 Jun 2019)
Sequence version 2 (03 Oct 2012)
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Protein

Protein jagged-2

Gene

Jag2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-MMU-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Jag2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098270 Jag2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 1082ExtracellularSequence analysisAdd BLAST1059
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1083 – 1103HelicalSequence analysisAdd BLAST21
Topological domaini1104 – 1247CytoplasmicSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000763024 – 1247Protein jagged-2Add BLAST1224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi198 ↔ 207By similarity
Disulfide bondi211 ↔ 223By similarity
Disulfide bondi231 ↔ 240By similarity
Disulfide bondi245 ↔ 256By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi276 ↔ 287By similarity
Disulfide bondi282 ↔ 293By similarity
Disulfide bondi295 ↔ 304By similarity
Disulfide bondi311 ↔ 323By similarity
Disulfide bondi317 ↔ 333By similarity
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi351 ↔ 362By similarity
Disulfide bondi356 ↔ 371By similarity
Disulfide bondi373 ↔ 382By similarity
Disulfide bondi389 ↔ 400By similarity
Disulfide bondi394 ↔ 409By similarity
Disulfide bondi411 ↔ 420By similarity
Disulfide bondi427 ↔ 438By similarity
Disulfide bondi432 ↔ 447By similarity
Disulfide bondi449 ↔ 458By similarity
Disulfide bondi465 ↔ 475By similarity
Disulfide bondi469 ↔ 484By similarity
Disulfide bondi486 ↔ 495By similarity
Disulfide bondi502 ↔ 513By similarity
Disulfide bondi507 ↔ 522By similarity
Disulfide bondi524 ↔ 533By similarity
Disulfide bondi540 ↔ 551By similarity
Disulfide bondi545 ↔ 560By similarity
Disulfide bondi562 ↔ 571By similarity
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi589 ↔ 612Sequence analysis
Disulfide bondi606 ↔ 622Sequence analysis
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi640 ↔ 651By similarity
Disulfide bondi645 ↔ 660By similarity
Disulfide bondi662 ↔ 671By similarity
Disulfide bondi678 ↔ 689By similarity
Disulfide bondi683 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity
Disulfide bondi716 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 747By similarity
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi755 ↔ 766By similarity
Disulfide bondi760 ↔ 775By similarity
Disulfide bondi777 ↔ 786By similarity
Disulfide bondi793 ↔ 804By similarity
Disulfide bondi798 ↔ 813By similarity
Disulfide bondi815 ↔ 824By similarity
Disulfide bondi831 ↔ 842By similarity
Disulfide bondi836 ↔ 851By similarity
Disulfide bondi853 ↔ 862By similarity
Glycosylationi1060N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1125PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9QYE5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9QYE5

PeptideAtlas

More...
PeptideAtlasi
Q9QYE5

PRoteomics IDEntifications database

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PRIDEi
Q9QYE5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QYE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QYE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found to be highest in fetal thymus, epidermis, foregut dorsal root ganglia and inner ear. In 2-weeK-old mice, abundant in heart, lung, thymus, skeletal muscle, brain and testis. Expression overlaps partially with Notch1 expression.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 13 dpc, found in paravertebral vessels and dorsal root ganglia. At 14 dpc, in oropharyngeal epithelium, developing thymus and in the muscles of the tongue. By 15 dpc, in many tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000002799 Expressed in 265 organ(s), highest expression level in primary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9QYE5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9QYE5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
200855, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000075224

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QYE5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 240DSLPROSITE-ProRule annotationAdd BLAST45
Domaini241 – 274EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini275 – 305EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini307 – 345EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini347 – 383EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini385 – 421EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini423 – 459EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini461 – 496EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini498 – 534EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini536 – 572EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini574 – 634EGF-like 10; atypicalPROSITE-ProRule annotationAdd BLAST61
Domaini636 – 672EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini674 – 710EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini712 – 748EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini751 – 787EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini789 – 825EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini827 – 863EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113124

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9QYE5

KEGG Orthology (KO)

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KOi
K21635

Database of Orthologous Groups

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OrthoDBi
72177at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351835

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR033108 Jag2
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom

The PANTHER Classification System

More...
PANTHERi
PTHR24049:SF18 PTHR24049:SF18, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 9 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 3 hits
PF07657 MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02059 JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00215 VWC_out, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 16 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QYE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRARGWGRLP RRLLLLLVLC VQATRPMGYF ELQLSALRNV NGELLSGACC
60 70 80 90 100
DGDGRTTRAG GCGRDECDTY VRVCLKEYQA KVTPTGPCSY GYGATPVLGG
110 120 130 140 150
NSFYLPPAGA AGDRARARSR TGGHQDPGLV VIPFQFAWPR SFTLIVEAWD
160 170 180 190 200
WDNDTTPDEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE
210 220 230 240 250
NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN
260 270 280 290 300
LLHGGCTVPG ECRCSYGWQG KFCDECVPYP GCVHGSCVEP WHCDCETNWG
310 320 330 340 350
GLLCDKDLNY CGSHHPCVNG GTCINAEPDQ YLCACPDGYL GKNCERAEHA
360 370 380 390 400
CASNPCANGG SCHEVPSGFE CHCPSGWNGP TCALDIDECA SNPCAAGGTC
410 420 430 440 450
VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCL
460 470 480 490 500
PGWKGINCQI NINDCHGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELEYD
510 520 530 540 550
KCASSPCRRG GICEDLVDGF RCHCPRGLSG LHCEVDMDLC EPSPCLNGAR
560 570 580 590 600
CYNLEGDYYC ACPEDFGGKN CSVPRDTCPG GACRVIDGCG FEAGSRARGV
610 620 630 640 650
APSGICGPHG HCVSLPGGNF SCICDSGFTG TYCHENIDDC MGQPCRNGGT
660 670 680 690 700
CIDEVDSFRC FCPSGWEGEL CDINPNDCLP DPCHSRGRCY DLVNDFYCAC
710 720 730 740 750
DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCTIA
760 770 780 790 800
KNSSCVPNPC VNGGTCVGSG DSFSCICRDG WEGRTCTHNT NDCNPLPCYN
810 820 830 840 850
GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR
860 870 880 890 900
CSCPPGRSGP RCQEVVIFTR PCWSRGMSFP HGSSWMEDCN SCRCLDGHRD
910 920 930 940 950
CSKVWCGWKP CLLSGQPSDP SAQCPPGQQC QEKAVGQCLQ PPCENWGECT
960 970 980 990 1000
AEEPLPPSTP CQPRSSHLDN NCARLTLRFN RDQVPQGTTV GAICSGIRAL
1010 1020 1030 1040 1050
PATRAAAHDR LLLLLCDRAS SGASAVEVAV SFSPARDLPD SSLIQSTAHA
1060 1070 1080 1090 1100
IVAAITQRGN SSLLLAVTEV KVETVVMGGS STGLLVPVLC SVFSVLWLAC
1110 1120 1130 1140 1150
VVICVWWTRK RRKERERSRL PRDESANNQW APLNPIRNPI ERPGGSGLGT
1160 1170 1180 1190 1200
GGHKDILYQC KNFTPPPRRA GEALPGPAGH GAGGEDEEDE ELSRGDGDSP
1210 1220 1230 1240
EAEKFISHKF TKDPSCSLGR PARWAPGPKV DNRAVRSTKD VRRAGRE
Length:1,247
Mass (Da):134,745
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1352B1856946EA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VLS8A0A1Y7VLS8_MOUSE
Protein jagged-2
Jag2
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti302L → M in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti378N → S in AAF16411 (Ref. 1) Curated1
Sequence conflicti378N → S in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti378N → S in CAA74835 (PubMed:9486542).Curated1
Sequence conflicti461N → T in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti469 – 478CQHGGTCKDL → VSAWGHLQGP in AAC14010 (PubMed:9341252).Curated10
Sequence conflicti492G → V in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti546L → F in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti549A → V in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti735 – 738RCAC → PAR in CAA74835 (PubMed:9486542).Curated4
Sequence conflicti809N → H in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti812R → A in AAC14010 (PubMed:9341252).Curated1
Sequence conflicti1030V → M in AAF16411 (Ref. 1) Curated1
Sequence conflicti1126A → T in AAF16411 (Ref. 1) Curated1
Sequence conflicti1223R → C in AAF16411 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF038572 mRNA Translation: AAF16411.1
AC160929 Genomic DNA No translation available.
AF010137 mRNA Translation: AAC14010.1
Y14495 mRNA Translation: CAA74835.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS26200.1

NCBI Reference Sequences

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RefSeqi
NP_034718.2, NM_010588.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799

Database of genes from NCBI RefSeq genomes

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GeneIDi
16450

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:16450

UCSC genome browser

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UCSCi
uc007pfl.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038572 mRNA Translation: AAF16411.1
AC160929 Genomic DNA No translation available.
AF010137 mRNA Translation: AAC14010.1
Y14495 mRNA Translation: CAA74835.1
CCDSiCCDS26200.1
RefSeqiNP_034718.2, NM_010588.2

3D structure databases

SMRiQ9QYE5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi200855, 1 interactor
STRINGi10090.ENSMUSP00000075224

PTM databases

iPTMnetiQ9QYE5
PhosphoSitePlusiQ9QYE5

Proteomic databases

MaxQBiQ9QYE5
PaxDbiQ9QYE5
PeptideAtlasiQ9QYE5
PRIDEiQ9QYE5

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
16450
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075827; ENSMUSP00000075224; ENSMUSG00000002799
GeneIDi16450
KEGGimmu:16450
UCSCiuc007pfl.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3714
MGIiMGI:1098270 Jag2

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00940000160944
HOGENOMiHOG000113124
InParanoidiQ9QYE5
KOiK21635
OrthoDBi72177at2759
TreeFamiTF351835

Enzyme and pathway databases

ReactomeiR-MMU-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-MMU-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9QYE5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000002799 Expressed in 265 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ9QYE5 baseline and differential
GenevisibleiQ9QYE5 MM

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR033108 Jag2
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PANTHERiPTHR24049:SF18 PTHR24049:SF18, 1 hit
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 9 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 3 hits
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 16 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJAG2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QYE5
Secondary accession number(s): F8VPV5, O55139, O70219
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 3, 2012
Last modified: June 5, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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