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Protein

Vitamin K-dependent gamma-carboxylase

Gene

Ggcx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Miscellaneous

The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO2, O2 and reduced vitamin K are cosubstrates.

Catalytic activityi

[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O = [peptidyl]-glutamate + CO2 + O2 + phylloquinol.

GO - Molecular functioni

  • gamma-glutamyl carboxylase activity Source: MGI
  • vitamin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

ReactomeiR-MMU-159740 Gamma-carboxylation of protein precursors

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin K-dependent gamma-carboxylase (EC:4.1.1.90)
Alternative name(s):
Gamma-glutamyl carboxylase
Peptidyl-glutamate 4-carboxylase
Vitamin K gamma glutamyl carboxylase
Gene namesi
Name:Ggcx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1927655 Ggcx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 60CytoplasmicSequence analysisAdd BLAST59
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 113LumenalSequence analysisAdd BLAST32
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 136CytoplasmicSequence analysis2
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 292LumenalSequence analysisAdd BLAST135
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 361CytoplasmicSequence analysisAdd BLAST48
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 757LumenalSequence analysisAdd BLAST375

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001918242 – 757Vitamin K-dependent gamma-carboxylaseAdd BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Disulfide bondi99 ↔ 450By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

MaxQBiQ9QYC7
PaxDbiQ9QYC7
PRIDEiQ9QYC7

PTM databases

iPTMnetiQ9QYC7
PhosphoSitePlusiQ9QYC7

Expressioni

Gene expression databases

BgeeiENSMUSG00000053460 Expressed in 161 organ(s), highest expression level in fibroblast
CleanExiMM_GGCX
ExpressionAtlasiQ9QYC7 baseline and differential
GenevisibleiQ9QYC7 MM

Interactioni

Subunit structurei

Monomer. May interact with CALU.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070109

Structurei

3D structure databases

SMRiQ9QYC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHG2 Eukaryota
ENOG410XR5Q LUCA
GeneTreeiENSGT00390000014909
HOGENOMiHOG000007593
HOVERGENiHBG012798
InParanoidiQ9QYC7
KOiK10106
OMAiYWNYFLI
OrthoDBiEOG091G07P8
PhylomeDBiQ9QYC7
TreeFamiTF323879

Family and domain databases

InterProiView protein in InterPro
IPR011020 HTTM
IPR011051 RmlC_Cupin_sf
IPR007782 VKG_COase
PANTHERiPTHR12639 PTHR12639, 1 hit
PfamiView protein in Pfam
PF05090 VKG_Carbox, 1 hit
SMARTiView protein in SMART
SM00752 HTTM, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9QYC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVHRGSALV APASDKVQKN KSAQTSGLKQ GSRMEKILGF EWTDLSSWQS
60 70 80 90 100
VVTLLNKPTD PANLAVFRFL FAFLMLLDIP QERGLSSLDR KYLDGLDVCR
110 120 130 140 150
FPLLDALRPL PLDWMYLVYT IMFLGALGMM LGLCYRLSCV LFLLPYWYVF
160 170 180 190 200
LLDKTSWNNH SYLYGLLAFQ LTFMDANHYW SVDGLLNARK KNAHVPLWNY
210 220 230 240 250
TVLRGQIFIV YFIAGVKKLD ADWVGGYSME HLSRHWLFSP FKLVLSEELT
260 270 280 290 300
SLLVVHWCGL LLDLSAGFLL FFDASRPVGL FFVSYFHCMN SQLFSIGMFP
310 320 330 340 350
YVMLASSPLF CSAEWPRKLV ARCPKRLQEL LPTKAAPRPS ASCVYKRSRG
360 370 380 390 400
KAGPKPGLRH QLGAIFTLLY LLEQLFLPYS HFLTQGYNNW TNGLYGYSWD
410 420 430 440 450
MMVHSRSHQH VKITYRDGLT GELGYLNPGV FTQSRRWKDH ADMLKQYATC
460 470 480 490 500
LSLLLPKYNV TEPQIYFDIW VSINDRFQQR LFDPRVDIVQ AVWSPFQRTP
510 520 530 540 550
WVQPLLMDLS PWRTKLQDIK SSLDNHTEVV FIADFPGLHL ENFVSEDLGN
560 570 580 590 600
TSIQLLQGEV TVELVAEQKN QTLQEGEKMQ LPAGEYHKVY TVSSSPSCYM
610 620 630 640 650
YVYVNTTEVA LEQDLAYLQE LKEKVENGSE TGPLPPELQP LLEGEVKGGP
660 670 680 690 700
EPTPLVQTFL RRQRKLQEIE RRRNSPFHER FLRFVLRKLY VFRRSFLMTR
710 720 730 740 750
ISLRNLLLGR PSLEQLAQEV TYANLRPFEP VDESSASNTD SSNHPSEPDS

EHVHSEF
Length:757
Mass (Da):87,195
Last modified:May 1, 2000 - v1
Checksum:i178CDDCEE5CFBA34
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RPG7A0A0U1RPG7_MOUSE
Vitamin K-dependent gamma-carboxyla...
Ggcx
45Annotation score:
A0A0U1RPT2A0A0U1RPT2_MOUSE
Vitamin K-dependent gamma-carboxyla...
Ggcx
125Annotation score:
A0A0U1RPU0A0A0U1RPU0_MOUSE
Vitamin K-dependent gamma-carboxyla...
Ggcx
55Annotation score:
A0A0U1RNG6A0A0U1RNG6_MOUSE
Vitamin K-dependent gamma-carboxyla...
Ggcx
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti525N → K in BAC28319 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087938 mRNA Translation: AAF21291.1
AK033496 mRNA Translation: BAC28319.1
AK036577 mRNA Translation: BAC29487.1
AK135425 mRNA Translation: BAE22528.1
CCDSiCCDS20242.1
RefSeqiNP_062776.1, NM_019802.5
UniGeneiMm.19937

Genome annotation databases

EnsembliENSMUST00000065906; ENSMUSP00000070109; ENSMUSG00000053460
ENSMUST00000194207; ENSMUSP00000141277; ENSMUSG00000103019
GeneIDi56316
KEGGimmu:56316
UCSCiuc009cio.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087938 mRNA Translation: AAF21291.1
AK033496 mRNA Translation: BAC28319.1
AK036577 mRNA Translation: BAC29487.1
AK135425 mRNA Translation: BAE22528.1
CCDSiCCDS20242.1
RefSeqiNP_062776.1, NM_019802.5
UniGeneiMm.19937

3D structure databases

SMRiQ9QYC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070109

PTM databases

iPTMnetiQ9QYC7
PhosphoSitePlusiQ9QYC7

Proteomic databases

MaxQBiQ9QYC7
PaxDbiQ9QYC7
PRIDEiQ9QYC7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065906; ENSMUSP00000070109; ENSMUSG00000053460
ENSMUST00000194207; ENSMUSP00000141277; ENSMUSG00000103019
GeneIDi56316
KEGGimmu:56316
UCSCiuc009cio.2 mouse

Organism-specific databases

CTDi2677
MGIiMGI:1927655 Ggcx

Phylogenomic databases

eggNOGiENOG410IHG2 Eukaryota
ENOG410XR5Q LUCA
GeneTreeiENSGT00390000014909
HOGENOMiHOG000007593
HOVERGENiHBG012798
InParanoidiQ9QYC7
KOiK10106
OMAiYWNYFLI
OrthoDBiEOG091G07P8
PhylomeDBiQ9QYC7
TreeFamiTF323879

Enzyme and pathway databases

ReactomeiR-MMU-159740 Gamma-carboxylation of protein precursors

Miscellaneous databases

PROiPR:Q9QYC7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053460 Expressed in 161 organ(s), highest expression level in fibroblast
CleanExiMM_GGCX
ExpressionAtlasiQ9QYC7 baseline and differential
GenevisibleiQ9QYC7 MM

Family and domain databases

InterProiView protein in InterPro
IPR011020 HTTM
IPR011051 RmlC_Cupin_sf
IPR007782 VKG_COase
PANTHERiPTHR12639 PTHR12639, 1 hit
PfamiView protein in Pfam
PF05090 VKG_Carbox, 1 hit
SMARTiView protein in SMART
SM00752 HTTM, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVKGC_MOUSE
AccessioniPrimary (citable) accession number: Q9QYC7
Secondary accession number(s): Q3UXN5, Q8CCB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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