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Protein

Alpha-adducin

Gene

Add1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-MMU-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-adducin
Alternative name(s):
Erythrocyte adducin subunit alpha
Gene namesi
Name:Add1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87918 Add1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185311 – 735Alpha-adducinAdd BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei59PhosphoserineCombined sources1
Modified residuei64PhosphoserineBy similarity1
Modified residuei331PhosphothreonineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei353PhosphoserineBy similarity1
Modified residuei355PhosphoserineCombined sources1
Modified residuei358PhosphothreonineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei429PhosphothreonineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei445Phosphothreonine; by ROCK2By similarity1
Modified residuei464PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei480Phosphothreonine; by ROCK2By similarity1
Modified residuei481Phosphoserine; by PKABy similarity1
Modified residuei586PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei610PhosphothreonineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei614PhosphothreonineCombined sources1
Modified residuei705PhosphoserineBy similarity1
Modified residuei708PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1
Modified residuei714Phosphoserine; by PKCBy similarity1
Modified residuei724Phosphoserine; by PKA and PKCBy similarity1
Isoform 2 (identifier: Q9QYC0-2)
Modified residuei600PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei610PhosphothreonineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei614PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9QYC0
PaxDbiQ9QYC0
PeptideAtlasiQ9QYC0
PRIDEiQ9QYC0

PTM databases

iPTMnetiQ9QYC0
PhosphoSitePlusiQ9QYC0
SwissPalmiQ9QYC0

Expressioni

Gene expression databases

BgeeiENSMUSG00000029106 Expressed in 287 organ(s), highest expression level in blood
CleanExiMM_ADD1
ExpressionAtlasiQ9QYC0 baseline and differential
GenevisibleiQ9QYC0 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197981, 9 interactors
IntActiQ9QYC0, 7 interactors
MINTiQ9QYC0
STRINGi10090.ENSMUSP00000109979

Structurei

3D structure databases

ProteinModelPortaliQ9QYC0
SMRiQ9QYC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni715 – 732Interaction with calmodulinSequence analysisAdd BLAST18

Domaini

Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3699 Eukaryota
COG0235 LUCA
GeneTreeiENSGT00390000016462
HOGENOMiHOG000116349
HOVERGENiHBG004180
InParanoidiQ9QYC0
KOiK18622
OMAiSFQKQQR
OrthoDBiEOG091G0324
PhylomeDBiQ9QYC0
TreeFamiTF313003

Family and domain databases

Gene3Di3.40.225.10, 1 hit
InterProiView protein in InterPro
IPR027766 ADD1
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
PANTHERiPTHR10672:SF4 PTHR10672:SF4, 1 hit
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QYC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGDTRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN
60 70 80 90 100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTA
110 120 130 140 150
SVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA
160 170 180 190 200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKV
210 220 230 240 250
NLQGDIVDRG STNLGVNQAG FTLHSAVYAA RPDAKCIVHI HTPAGAAVSA
260 270 280 290 300
MKCGLLPISP EALSLGDVAY HDYHGILVDE EEKILIQKNL GPKSKVLILR
310 320 330 340 350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLDPGKYK
360 370 380 390 400
AKSRSPGTPA GEGSGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL
410 420 430 440 450
RERSKKYSDV EVPASVTGHS FASDGDSGTC SPLRHSFQKQ QREKTRWLHS
460 470 480 490 500
GRGDDASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ
510 520 530 540 550
EMRNKIREQN LQDIKTAGPQ SQVLCGVMMD RSLVQGELVT ASKAIIEKEY
560 570 580 590 600
QPHVIVSTTG PNPFNTLTDR ELEEYRREVE RKQKGSEENL DETREQKEKS
610 620 630 640 650
PPDQSAVPNT PPSTPVKLEE DLPQEPTSRD DSDATTFKPT PPDLSPDEPS
660 670 680 690 700
EALAFPAVEE EAHASPDPTQ PPAEADPEPA SAPTPGAEEV ASPATEEGSP
710 720 730
MDPGSDGSPG KSPSKKKKKF RTPSFLKKSK KKSDS
Length:735
Mass (Da):80,647
Last modified:December 1, 2000 - v2
Checksum:iE6AAA7F6273A33DD
GO
Isoform 2 (identifier: Q9QYC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-632: DLPQEPTSRDDS → AGDGCAKEYLLP
     633-735: Missing.

Show »
Length:632
Mass (Da):69,887
Checksum:iEA5ED051D13C6B38
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGR0F8WGR0_MOUSE
Alpha-adducin
Add1
663Annotation score:
E9Q1K3E9Q1K3_MOUSE
Alpha-adducin
Add1
660Annotation score:
F8WHZ9F8WHZ9_MOUSE
Alpha-adducin
Add1
662Annotation score:
F6RDR0F6RDR0_MOUSE
Alpha-adducin
Add1
160Annotation score:
A0A0J9YVI4A0A0J9YVI4_MOUSE
Alpha-adducin
Add1
248Annotation score:
F6V4G5F6V4G5_MOUSE
Alpha-adducin
Add1
135Annotation score:
D3Z0T1D3Z0T1_MOUSE
Alpha-adducin
Add1
141Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234A → T in AAF29504 (PubMed:10845937).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000177621 – 632DLPQE…SRDDS → AGDGCAKEYLLP in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_000178633 – 735Missing in isoform 2. CuratedAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096839 mRNA Translation: AAF24971.1
AF189771 mRNA Translation: AAF29504.1
CCDSiCCDS19216.1 [Q9QYC0-1]
CCDS39069.1 [Q9QYC0-2]
RefSeqiNP_001019629.2, NM_001024458.4 [Q9QYC0-1]
NP_001095914.1, NM_001102444.2
NP_001318009.1, NM_001331080.1 [Q9QYC0-1]
NP_001318016.1, NM_001331087.1 [Q9QYC0-2]
NP_038485.1, NM_013457.4 [Q9QYC0-2]
XP_017176104.1, XM_017320615.1 [Q9QYC0-2]
UniGeneiMm.289106

Genome annotation databases

EnsembliENSMUST00000114338; ENSMUSP00000109977; ENSMUSG00000029106 [Q9QYC0-2]
ENSMUST00000114340; ENSMUSP00000109979; ENSMUSG00000029106 [Q9QYC0-1]
GeneIDi11518
KEGGimmu:11518
UCSCiuc008xcp.1 mouse [Q9QYC0-2]
uc008xcr.1 mouse [Q9QYC0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096839 mRNA Translation: AAF24971.1
AF189771 mRNA Translation: AAF29504.1
CCDSiCCDS19216.1 [Q9QYC0-1]
CCDS39069.1 [Q9QYC0-2]
RefSeqiNP_001019629.2, NM_001024458.4 [Q9QYC0-1]
NP_001095914.1, NM_001102444.2
NP_001318009.1, NM_001331080.1 [Q9QYC0-1]
NP_001318016.1, NM_001331087.1 [Q9QYC0-2]
NP_038485.1, NM_013457.4 [Q9QYC0-2]
XP_017176104.1, XM_017320615.1 [Q9QYC0-2]
UniGeneiMm.289106

3D structure databases

ProteinModelPortaliQ9QYC0
SMRiQ9QYC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197981, 9 interactors
IntActiQ9QYC0, 7 interactors
MINTiQ9QYC0
STRINGi10090.ENSMUSP00000109979

PTM databases

iPTMnetiQ9QYC0
PhosphoSitePlusiQ9QYC0
SwissPalmiQ9QYC0

Proteomic databases

EPDiQ9QYC0
PaxDbiQ9QYC0
PeptideAtlasiQ9QYC0
PRIDEiQ9QYC0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114338; ENSMUSP00000109977; ENSMUSG00000029106 [Q9QYC0-2]
ENSMUST00000114340; ENSMUSP00000109979; ENSMUSG00000029106 [Q9QYC0-1]
GeneIDi11518
KEGGimmu:11518
UCSCiuc008xcp.1 mouse [Q9QYC0-2]
uc008xcr.1 mouse [Q9QYC0-1]

Organism-specific databases

CTDi118
MGIiMGI:87918 Add1

Phylogenomic databases

eggNOGiKOG3699 Eukaryota
COG0235 LUCA
GeneTreeiENSGT00390000016462
HOGENOMiHOG000116349
HOVERGENiHBG004180
InParanoidiQ9QYC0
KOiK18622
OMAiSFQKQQR
OrthoDBiEOG091G0324
PhylomeDBiQ9QYC0
TreeFamiTF313003

Enzyme and pathway databases

ReactomeiR-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-MMU-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRSiAdd1 mouse
PROiPR:Q9QYC0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029106 Expressed in 287 organ(s), highest expression level in blood
CleanExiMM_ADD1
ExpressionAtlasiQ9QYC0 baseline and differential
GenevisibleiQ9QYC0 MM

Family and domain databases

Gene3Di3.40.225.10, 1 hit
InterProiView protein in InterPro
IPR027766 ADD1
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
PANTHERiPTHR10672:SF4 PTHR10672:SF4, 1 hit
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADDA_MOUSE
AccessioniPrimary (citable) accession number: Q9QYC0
Secondary accession number(s): Q9JLE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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