Casr

Functionⁱ

G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (By similarity). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (PubMed:7493018). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity).By similarity1 Publication

Activity regulationⁱ

In resting state, adopts an open conformation, anion-binding promoting the inactive configuration. Upon aromatic amino acid-binding, the groove in the extracellular venus flytrap module is closed, thereby inducing the formation of a novel homodimer interface between subunits. Calcium ions stabilize the active state by enhancing homodimer interactions between membrane-proximal domains to fully activate the receptor.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	81	Calcium; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	84	CalciumBy similarity	1
Metal bindingⁱ	87	Calcium; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	88	Calcium; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	100	CalciumBy similarity	1
Metal bindingⁱ	145	CalciumBy similarity	1
Binding siteⁱ	147	Aromatic amino acidBy similarity	1
Binding siteⁱ	168	Aromatic amino acid; via carbonyl oxygenBy similarity	1
Binding siteⁱ	170	Aromatic amino acidBy similarity	1
Metal bindingⁱ	231	CalciumBy similarity	1
Metal bindingⁱ	234	CalciumBy similarity	1
Binding siteⁱ	297	Aromatic amino acidBy similarity	1
Metal bindingⁱ	557	Calcium; via carbonyl oxygenBy similarity	1

GO - Molecular functionⁱ

amino acid binding Source: UniProtKB
calcium ion binding Source: UniProtKB
drug binding Source: MGI
G-protein coupled receptor activity Source: UniProtKB
integrin binding Source: MGI
ion channel binding Source: MGI
magnesium ion binding Source: MGI
polyamine binding Source: MGI
protein homodimerization activity Source: UniProtKB
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
apoptotic process Source: Ensembl
bile acid secretion Source: Ensembl
branching morphogenesis of an epithelial tube Source: MGI
calcium ion import Source: MGI
calcium ion transport Source: MGI
cellular calcium ion homeostasis Source: UniProtKB
cellular response to glucose stimulus Source: Ensembl
cellular response to hepatocyte growth factor stimulus Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to low-density lipoprotein particle stimulus Source: Ensembl
cellular response to peptide Source: Ensembl
cellular response to vitamin D Source: Ensembl
chloride transmembrane transport Source: Ensembl
detection of calcium ion Source: UniProtKB
fat pad development Source: Ensembl
G-protein coupled receptor signaling pathway Source: UniProtKB
JNK cascade Source: MGI
ossification Source: MGI
phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
positive regulation of ATPase activity
Source: MGI
Inferred from direct assayⁱ
- 17823248
positive regulation of calcium ion import Source: MGI
positive regulation of cell proliferation Source: MGI
positive regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 18794335
positive regulation of insulin secretion Source: MGI
positive regulation of positive chemotaxis Source: MGI
positive regulation of vasoconstriction Source: MGI
regulation of calcium ion transport
Source: MGI
Inferred from direct assayⁱ
- 17823248
response to fibroblast growth factor Source: Ensembl
response to ischemia Source: Ensembl
vasodilation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-416476 G alpha (q) signalling events R-MMU-418594 G alpha (i) signalling events R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Reactomeⁱ

R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Extracellular calcium-sensing receptor Short name: CaSR Alternative name(s): Parathyroid cell calcium-sensing receptor Short name: PCaR1
Gene namesⁱ	Name:CasrImported Synonyms:Gprc2a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 16

Organism-specific databases

MGIⁱ	MGI:1351351 Casr

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 612	ExtracellularSequence analysisAdd BLAST	593
Transmembraneⁱ	613 – 635	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	636 – 649	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	650 – 670	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	671 – 681	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	682 – 700	Helical; Name=3Sequence analysisAdd BLAST	19
Topological domainⁱ	701 – 724	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	725 – 745	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	746 – 769	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	770 – 792	Helical; Name=5Sequence analysisAdd BLAST	23
Topological domainⁱ	793 – 805	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	806 – 828	Helical; Name=6Sequence analysisAdd BLAST	23
Topological domainⁱ	829 – 836	ExtracellularSequence analysis	8
Transmembraneⁱ	837 – 862	Helical; Name=7Sequence analysisAdd BLAST	26
Topological domainⁱ	863 – 1079	CytoplasmicSequence analysisAdd BLAST	217

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Heterozygous mice show benign and modest elevations of serum calcium, magnesium and parathyroid hormone levels as well as hypocalciuria. Homozygous mice show neonatal severe hyperparathyroidism, had markedly elevated serum calcium and parathyroid hormone levels, parathyroid hyperplasia, bone abnormalities, retarded growth and premature death.1 Publication

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	54

GuidetoPHARMACOLOGYⁱ

54

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000012947	20 – 1079	Extracellular calcium-sensing receptorAdd BLAST		1060

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	60 ↔ 101	By similarity
Glycosylationⁱ	90	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	129	InterchainBy similarity
Glycosylationⁱ	130	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	131	InterchainBy similarity
Disulfide bondⁱ	236 ↔ 561	By similarity
Glycosylationⁱ	261	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	287	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	358 ↔ 395	By similarity
Glycosylationⁱ	386	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	437 ↔ 449	By similarity
Glycosylationⁱ	446	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	468	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	488	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	541	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	542 ↔ 562	By similarity
Disulfide bondⁱ	546 ↔ 565	By similarity
Disulfide bondⁱ	568 ↔ 582	By similarity
Disulfide bondⁱ	585 ↔ 598	By similarity
Glycosylationⁱ	594	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	920	PhosphoserineCombined sources	1
Modified residueⁱ	1062	PhosphoserineCombined sources	1

Post-translational modificationⁱ

N-glycosylated.By similarity

Ubiquitinated by RNF19A; which induces proteasomal degradation.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9QY96
PRIDEⁱ	Q9QY96

PTM databases

iPTMnetⁱ	Q9QY96
PhosphoSitePlusⁱ	Q9QY96

Expressionⁱ

Tissue specificityⁱ

Epidermis, kidney and cartilage.4 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000051980 Expressed in 84 organ(s), highest expression level in spinal cord
CleanExⁱ	MM_CASR
Genevisibleⁱ	Q9QY96 MM

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked. Interacts with VCP and RNF19A (By similarity). Interacts with ARRB1 (By similarity).By similarity

GO - Molecular functionⁱ

integrin binding Source: MGI
ion channel binding Source: MGI
protein homodimerization activity Source: UniProtKB
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000069080

STRINGⁱ

10090.ENSMUSP00000069080

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QY96
SMRⁱ	Q9QY96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	22 – 188	Ligand-binding 1 (LB1)By similarityAdd BLAST	167
Regionⁱ	66 – 70	Anion bindingBy similarity	5
Regionⁱ	189 – 324	Ligand-binding 2 (LB2)By similarityAdd BLAST	136
Regionⁱ	415 – 417	Anion bindingBy similarity	3
Regionⁱ	542 – 612	Cysteine-rich (CR)By similarityAdd BLAST	71
Regionⁱ	880 – 900	Interaction with RNF19ABy similarityAdd BLAST	21

Domainⁱ

The extracellular regions of the homodimer interact in a side-by-side fashion while facing opposite directions. Each extracellular region consists of three domains, LB1 (ligand-binding 1), LB2 and CR (cysteine-rich). The two lobe-shaped domains LB1 and LB2 form a venus flytrap module. In the inactive configuration, the venus flytrap modules of both protomers are in the open conformation associated with the resting state (open-open) and the interdomain cleft is empty. In addition, each protomer contains three anions, which reinforce the inactive conformation, and one calcium ion. In the active configuration, both protomers of extracellular regions have the closed conformation associated with agonist-binding (closed-closed). The ligand-binding cleft of each protomer is solely occupied by an aromatic amino-acid. Calcium is bound at four novel sites, including one at the homodimer interface. Agonist-binding induces large conformational changes within the extracellular region homodimer: first, the venus flytrap module of each protomer undergoes domain closure. Second, the LB2 regions of the two protomers approach each other, resulting in an expansion of the homodimer interactions involving LB2 domains. Third, the CR regions of the two subunits interact to form a large homodimer interface that is unique to the active state. The CR regions are brought into close contact by the motion involving LB2 since the two domains are rigidly associated within each subunit.By similarity

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118974
HOVERGENⁱ	HBG052876
InParanoidⁱ	Q9QY96
KEGG Orthology (KO) More...KOⁱ	K04612
OMAⁱ	GYTCLLA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01NA
TreeFamⁱ	TF331269

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR028082 Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform A (identifier: Q9QY96-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWFGYCLAL LALTWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD 
        60         70         80         90        100
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPALLPN MTLGYRIFDT 
       110        120        130        140        150
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGVS 
       160        170        180        190        200
TAVANLLGLF YIPQVSYASS SRLLSNKNQF KSFLRTIPND EHQATAMADI 
       210        220        230        240        250
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE 
       260        270        280        290        300
EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA 
       310        320        330        340        350
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE 
       360        370        380        390        400
FWEETFNCHL QDGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN 
       410        420        430        440        450
INSVETPYMD YEHLRISYNV YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA 
       460        470        480        490        500
DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD ECGDLVGNYS IINWHLSPED 
       510        520        530        540        550
GSIVFKEVGY YNVYAKKGER LFINEGKILW SGFSREVPFS NCSRDCQAGT 
       560        570        580        590        600
RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA 
       610        620        630        640        650
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL 
       660        670        680        690        700
SYLLLFSLLC CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN 
       710        720        730        740        750
RVLLVFEAKI PTSFHRKWWG LNLQFLLVFL CTFMQIVICI IWLYTAPPSS 
       760        770        780        790        800
YRNHELEDEI IFITCHEGSL MALGSLIGYT CLLAAICFFF AFKSRKLPEN 
       810        820        830        840        850
FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA ILAASFGLLA 
       860        870        880        890        900
CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS 
       910        920        930        940        950
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLALTQ QEQQQQPLTL 
       960        970        980        990       1000
QPQQQQQPQQ PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE 
      1010       1020       1030       1040       1050
AQKSNDTLNR HQALLPLQCA EADSEMTIQE TGLQGPMVGD HQPEIESPDE 
      1060       1070 
MSPALVMSTS RSFVISGGGS SVTENILHS

Length:1,079

Mass (Da):120,903

Last modified:October 3, 2012 - v2

Checksum:ⁱ8AEF586CDCD93CB3

GO

Isoform B (identifier: Q9QY96-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
461-537: Missing.

« Hide

        10         20         30         40         50
MAWFGYCLAL LALTWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD 
        60         70         80         90        100
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPALLPN MTLGYRIFDT 
       110        120        130        140        150
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGVS 
       160        170        180        190        200
TAVANLLGLF YIPQVSYASS SRLLSNKNQF KSFLRTIPND EHQATAMADI 
       210        220        230        240        250
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE 
       260        270        280        290        300
EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA 
       310        320        330        340        350
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE 
       360        370        380        390        400
FWEETFNCHL QDGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN 
       410        420        430        440        450
INSVETPYMD YEHLRISYNV YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA 
       460        470        480        490        500
DIKKVEAWQV PFSNCSRDCQ AGTRKGIIEG EPTCCFECVE CPDGEYSGET 
       510        520        530        540        550
DASACDKCPD DFWSNENHTS CIAKEIEFLA WTEPFGIALT LFAVLGIFLT 
       560        570        580        590        600
AFVLGVFIKF RNTPIVKATN RELSYLLLFS LLCCFSSSLF FIGEPQDWTC 
       610        620        630        640        650
RLRQPAFGIS FVLCISCILV KTNRVLLVFE AKIPTSFHRK WWGLNLQFLL 
       660        670        680        690        700
VFLCTFMQIV ICIIWLYTAP PSSYRNHELE DEIIFITCHE GSLMALGSLI 
       710        720        730        740        750
GYTCLLAAIC FFFAFKSRKL PENFNEAKFI TFSMLIFFIV WISFIPAYAS 
       760        770        780        790        800
TYGKFVSAVE VIAILAASFG LLACIFFNKV YIILFKPSRN TIEEVRSSTA 
       810        820        830        840        850
AHAFKVAARA TLRRPNISRK RSSSLGGSTG SIPSSSISSK SNSEDRFPQP 
       860        870        880        890        900
ERQKQQQPLA LTQQEQQQQP LTLQPQQQQQ PQQPRCKQKV IFGSGTVTFS 
       910        920        930        940        950
LSFDEPQKNA MAHRNSMRQN SLEAQKSNDT LNRHQALLPL QCAEADSEMT 
       960        970        980        990       1000
IQETGLQGPM VGDHQPEIES PDEMSPALVM STSRSFVISG GGSSVTENIL 

HS

Show »

Length:1,002

Mass (Da):111,996

Checksum:ⁱ94BF8B687C0FD877

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	45	A → S in AAD40638 (PubMed:10652312).Curated	1
Sequence conflictⁱ	304	L → P in AAF00193 (PubMed:10579354).Curated	1
Sequence conflictⁱ	410	D → G in AAD28371 (PubMed:10625662).Curated	1
Sequence conflictⁱ	410	D → G in AAD28372 (PubMed:10625662).Curated	1
Sequence conflictⁱ	566	V → A in AAD40638 (PubMed:10652312).Curated	1
Sequence conflictⁱ	595	H → Y in AAD28371 (PubMed:10625662).Curated	1
Sequence conflictⁱ	595	H → Y in AAD28372 (PubMed:10625662).Curated	1
Sequence conflictⁱ	610	E → V in BAA77688 (Ref. 7) Curated	1
Sequence conflictⁱ	814	F → L in BAA77688 (Ref. 7) Curated	1
Sequence conflictⁱ	889	L → I in AAD40638 (PubMed:10652312).Curated	1
Sequence conflictⁱ	906 – 908	TGS → SGW in AAD40638 (PubMed:10652312).Curated	3
Sequence conflictⁱ	909	I → N in AAD28371 (PubMed:10625662).Curated	1
Sequence conflictⁱ	909	I → N in AAD28372 (PubMed:10625662).Curated	1
Sequence conflictⁱ	1057	M → V in AAD28371 (PubMed:10625662).Curated	1
Sequence conflictⁱ	1057	M → V in AAD28372 (PubMed:10625662).Curated	1
Sequence conflictⁱ	1064	V → A in AAD40638 (PubMed:10652312).Curated	1
Sequence conflictⁱ	1076	I → V in AAD40638 (PubMed:10652312).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002036	461 – 537	Missing in isoform B. CuratedAdd BLAST		77

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF110178 mRNA Translation: AAD28371.1 AF110179 mRNA Translation: AAD28372.1 AF128842 mRNA Translation: AAD40638.1 AC074229 Genomic DNA No translation available. CH466521 Genomic DNA Translation: EDK97924.1 AF068900 mRNA Translation: AAC19388.1 AB027140 mRNA Translation: BAA77688.1 AF002015 Genomic DNA Translation: AAC53252.1 AF159565 mRNA Translation: AAF00193.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28154.1 [Q9QY96-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_038831.2, NM_013803.3 [Q9QY96-1] XP_006521792.1, XM_006521729.2 [Q9QY96-1] XP_006521793.1, XM_006521730.2 [Q9QY96-1] XP_006521794.1, XM_006521731.3 [Q9QY96-1] XP_006521795.1, XM_006521732.2 [Q9QY96-1]
UniGeneⁱ	Mm.103619 Mm.393142

Genome annotation databases

Ensemblⁱ	ENSMUST00000063597; ENSMUSP00000069080; ENSMUSG00000051980 [Q9QY96-1] ENSMUST00000114847; ENSMUSP00000110496; ENSMUSG00000051980 [Q9QY96-2] ENSMUST00000172826; ENSMUSP00000133500; ENSMUSG00000051980 [Q9QY96-1]
GeneIDⁱ	12374
KEGGⁱ	mmu:12374
UCSC genome browser More...UCSCⁱ	uc007zcp.1 mouse [Q9QY96-1] uc012afg.1 mouse [Q9QY96-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QY96	Uncharacterized protein (Fragment)		MOUSE		783	UniRef100_Q9QY96
UPI0003D77550		MOUSE		883

Protein	Similar proteins		Species	Score	Length	Source
Q9QY96	Extracellular calcium-sensing receptor	)	HUMAN		1078	UniRef90_P41180
Extracellular calcium-sensing receptor		BOVIN		1085
Extracellular calcium-sensing receptor		PIG		1079
Extracellular calcium-sensing receptor		RAT		1079
extracellular calcium-sensing receptor isoform X1		DIPOR		1112
+200
Q9QY96-2	Uncharacterized protein		FELCA		1004	UniRef90_Q9QY96-2
Calcium sensing receptor		CALJA		1002
Extracellular calcium-sensing receptor		HUMAN		1001
CASR isoform 4		PANTR		1001
Calcium sensing receptor		SAIBB		1001
+18

Protein	Similar proteins		Species	Score	Length	Source
Q9QY96	Extracellular calcium-sensing receptor	)	HUMAN		1078	UniRef50_P41180
Extracellular calcium-sensing receptor		BOVIN		1085
Extracellular calcium-sensing receptor		PIG		1079
Extracellular calcium-sensing receptor		RAT		1079
extracellular calcium-sensing receptor isoform X1		DIPOR		1112
+360
Q9QY96-2	Uncharacterized protein		FELCA		1004	UniRef50_Q9QY96-2
Calcium sensing receptor		CALJA		1002
Uncharacterized protein		RHIRO		1001
Uncharacterized protein		RHIBE		1001
Uncharacterized protein		NOMLE		1001
+22

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF110178 mRNA Translation: AAD28371.1 AF110179 mRNA Translation: AAD28372.1 AF128842 mRNA Translation: AAD40638.1 AC074229 Genomic DNA No translation available. CH466521 Genomic DNA Translation: EDK97924.1 AF068900 mRNA Translation: AAC19388.1 AB027140 mRNA Translation: BAA77688.1 AF002015 Genomic DNA Translation: AAC53252.1 AF159565 mRNA Translation: AAF00193.1
CCDSⁱ	CCDS28154.1 [Q9QY96-1]
RefSeqⁱ	NP_038831.2, NM_013803.3 [Q9QY96-1] XP_006521792.1, XM_006521729.2 [Q9QY96-1] XP_006521793.1, XM_006521730.2 [Q9QY96-1] XP_006521794.1, XM_006521731.3 [Q9QY96-1] XP_006521795.1, XM_006521732.2 [Q9QY96-1]
UniGeneⁱ	Mm.103619 Mm.393142

3D structure databases

ProteinModelPortalⁱ	Q9QY96
SMRⁱ	Q9QY96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000069080

STRINGⁱ

10090.ENSMUSP00000069080

Chemistry databases

GuidetoPHARMACOLOGYⁱ	54

GuidetoPHARMACOLOGYⁱ

54

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q9QY96
PhosphoSitePlusⁱ	Q9QY96

Proteomic databases

PaxDbⁱ	Q9QY96
PRIDEⁱ	Q9QY96

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	12374
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000063597; ENSMUSP00000069080; ENSMUSG00000051980 [Q9QY96-1] ENSMUST00000114847; ENSMUSP00000110496; ENSMUSG00000051980 [Q9QY96-2] ENSMUST00000172826; ENSMUSP00000133500; ENSMUSG00000051980 [Q9QY96-1]
GeneIDⁱ	12374
KEGGⁱ	mmu:12374
UCSCⁱ	uc007zcp.1 mouse [Q9QY96-1] uc012afg.1 mouse [Q9QY96-2]

Organism-specific databases

CTDⁱ	846
MGIⁱ	MGI:1351351 Casr

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
GeneTreeⁱ	ENSGT00760000118974
HOVERGENⁱ	HBG052876
InParanoidⁱ	Q9QY96
KOⁱ	K04612
OMAⁱ	GYTCLLA
OrthoDBⁱ	EOG091G01NA
TreeFamⁱ	TF331269

Enzyme and pathway databases

Reactomeⁱ	R-MMU-416476 G alpha (q) signalling events R-MMU-418594 G alpha (i) signalling events R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Reactomeⁱ

R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9QY96
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000051980 Expressed in 84 organ(s), highest expression level in spinal cord
CleanExⁱ	MM_CASR
Genevisibleⁱ	Q9QY96 MM

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR028082 Peripla_BP_I
Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CASR_MOUSE
Accessionⁱ	Q9QY96Primary (citable) accession number: Q9QY96 Secondary accession number(s): G3UX06 Q9R1Y2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	October 3, 2012
	Last modified:	October 10, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9QY96 (CASR_MOUSE)

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Extracellular calcium-sensing receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Chemistry databases

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Keywords - PTMi

Proteomic databases

PTM databases

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Gene expression databases

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GO - Molecular functioni

Protein-protein interaction databases

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3D structure databases

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Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

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Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Protocols and materials databases

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Enzyme and pathway databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ