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Protein

Vesicle-associated membrane protein-associated protein B

Gene

Vapb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein-associated protein B
Short name:
VAMP-B
Short name:
VAMP-associated protein B
Short name:
VAP-B
Alternative name(s):
VAMP-associated protein 33b
Gene namesi
Name:Vapb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1928744 Vapb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 218CytoplasmicSequence analysisAdd BLAST217
Transmembranei219 – 239Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002134742 – 243Vesicle-associated membrane protein-associated protein BAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei156PhosphoserineBy similarity1
Modified residuei159PhosphoserineCombined sources1
Modified residuei206PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9QY76
MaxQBiQ9QY76
PaxDbiQ9QY76
PRIDEiQ9QY76

PTM databases

iPTMnetiQ9QY76
PhosphoSitePlusiQ9QY76

Interactioni

Subunit structurei

Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2 (By similarity). Interacts (via MSP domain) with ZFYVE27 (PubMed:24251978). Interacts with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts with STARD3 (via FFAT motif) (By similarity). Interacts with STARD3NL (via FFAT motif) (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QY76, 3 interactors
STRINGi10090.ENSMUSP00000064699

Structurei

3D structure databases

ProteinModelPortaliQ9QY76
SMRiQ9QY76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 124MSPPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili161 – 196Sequence analysisAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
HOGENOMiHOG000293182
HOVERGENiHBG028551
InParanoidiQ9QY76
PhylomeDBiQ9QY76

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
IPR030226 VapB
PANTHERiPTHR10809 PTHR10809, 1 hit
PTHR10809:SF12 PTHR10809:SF12, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
PIRSFiPIRSF019693 VAMP-associated, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QY76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTVPR
60 70 80 90 100
RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS
110 120 130 140 150
DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI IPTSASKTEA
160 170 180 190 200
PAAAKSLTSP LDDTEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRVRK
210 220 230 240
AMPSNSPVAA LAATGKEEGL SARLLALVVL FFIVGVIIGK IAL
Length:243
Mass (Da):26,946
Last modified:January 23, 2007 - v3
Checksum:i9D88CBC31701C84E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BH80Q8BH80_MOUSE
Vesicle-associated membrane protein...
Vapb mCG_13760
243Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115504 mRNA Translation: AAF23077.1
CCDSiCCDS17146.1
UniGeneiMm.260456

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115504 mRNA Translation: AAF23077.1
CCDSiCCDS17146.1
UniGeneiMm.260456

3D structure databases

ProteinModelPortaliQ9QY76
SMRiQ9QY76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QY76, 3 interactors
STRINGi10090.ENSMUSP00000064699

PTM databases

iPTMnetiQ9QY76
PhosphoSitePlusiQ9QY76

Proteomic databases

EPDiQ9QY76
MaxQBiQ9QY76
PaxDbiQ9QY76
PRIDEiQ9QY76

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1928744 Vapb

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
HOGENOMiHOG000293182
HOVERGENiHBG028551
InParanoidiQ9QY76
PhylomeDBiQ9QY76

Miscellaneous databases

ChiTaRSiVapb mouse
PROiPR:Q9QY76
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
IPR030226 VapB
PANTHERiPTHR10809 PTHR10809, 1 hit
PTHR10809:SF12 PTHR10809:SF12, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
PIRSFiPIRSF019693 VAMP-associated, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAPB_MOUSE
AccessioniPrimary (citable) accession number: Q9QY76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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