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Protein

Transmembrane protein 59

Gene

Tmem59

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.By similarity

GO - Molecular functioni

  • endopeptidase activity Source: MGI

GO - Biological processi

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 59
Alternative name(s):
Thymic dendritic cell-derived factor 1
Gene namesi
Name:Tmem59
Synonyms:ORF18, Tdcf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1929278 Tmem59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 238ExtracellularSequence analysisAdd BLAST203
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 323CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000000300436 – 323Transmembrane protein 59Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei303PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9QY73
MaxQBiQ9QY73
PaxDbiQ9QY73
PeptideAtlasiQ9QY73
PRIDEiQ9QY73

PTM databases

iPTMnetiQ9QY73
PhosphoSitePlusiQ9QY73
SwissPalmiQ9QY73

Expressioni

Gene expression databases

BgeeiENSMUSG00000028618 Expressed in 108 organ(s), highest expression level in female gonad
CleanExiMM_TMEM59
ExpressionAtlasiQ9QY73 baseline and differential

Interactioni

Subunit structurei

Interacts with ATG16L1 (via WD repeats).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030361

Structurei

3D structure databases

ProteinModelPortaliQ9QY73
SMRiQ9QY73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi263 – 281ATG16L1-binding motifBy similarityAdd BLAST19

Domaini

The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.By similarity

Sequence similaritiesi

Belongs to the TMEM59 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIST Eukaryota
ENOG410XTCW LUCA
GeneTreeiENSGT00390000008279
HOGENOMiHOG000015759
HOVERGENiHBG018206
InParanoidiQ9QY73
OMAiQEPTNLK
OrthoDBiEOG091G0EVN
PhylomeDBiQ9QY73
TreeFamiTF331226

Family and domain databases

InterProiView protein in InterPro
IPR022065 Uncharacterised_TMEM59
PANTHERiPTHR28652 PTHR28652, 1 hit
PfamiView protein in Pfam
PF12280 BSMAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9QY73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPKGKLWV QAQLGLPPLL LLTMALAGGS GTAAAEAFDS VLGDTASCHR
60 70 80 90 100
ACQLTYPLHT YPKEEELYAC QRGCRLFSIC QFVDDGLDLN RTKLECESAC
110 120 130 140 150
TEAYSQPDEQ YACHLGCQDQ LPFAELRQEQ LMSLMPRMHL LFPLTLVRSF
160 170 180 190 200
WSDMMDSAQS FITSSWTFYL QADDGKIVIF QSKPEIQYAP QLEQEPTNLR
210 220 230 240 250
ESSLSKMSYL QMRNSQAHRN YLEEEESDGF LRCLSLNSGW ILTTTLVLSV
260 270 280 290 300
MVLLWICCAA VATAVEQYVP PEKLSIYGDL EFMNEQKLSR YPAPSLVIVR
310 320
SQTEEHEEAG PLPTKVNLAH SEI
Length:323
Mass (Da):36,314
Last modified:September 26, 2001 - v2
Checksum:i0E9BF6B6E07C7D96
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVM2D3YVM2_MOUSE
Transmembrane protein 59
Tmem59
256Annotation score:
D6RI96D6RI96_MOUSE
Transmembrane protein 59
Tmem59
90Annotation score:
D3Z0H8D3Z0H8_MOUSE
Transmembrane protein 59
Tmem59
127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48C → V in AAF20283 (Ref. 1) Curated1
Sequence conflicti103A → T in AAF20283 (Ref. 1) Curated1
Sequence conflicti121L → W in AAF20283 (Ref. 1) Curated1
Sequence conflicti139H → Q in AAF20283 (Ref. 1) Curated1
Sequence conflicti221 – 222YL → DR in AAF20283 (Ref. 1) Curated2
Sequence conflicti248L → F in AAH45145 (PubMed:15489334).Curated1
Sequence conflicti264A → G in AAF20283 (Ref. 1) Curated1
Sequence conflicti277 – 300YGDLE…LVIVR → IGHFQFINQQNLTTYPPPPL LIVK in AAF20283 (Ref. 1) CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116911 mRNA Translation: AAF20283.1
AK003252 mRNA Translation: BAB22668.2
AK050162 mRNA Translation: BAC34103.1
AK145644 mRNA Translation: BAE26561.1
AK159761 mRNA Translation: BAE35352.1
AK166772 mRNA Translation: BAE39008.1
AK167058 mRNA Translation: BAE39221.1
BC002164 mRNA Translation: AAH02164.1
BC014732 mRNA Translation: AAH14732.1
BC018379 mRNA Translation: AAH18379.1
BC045145 mRNA Translation: AAH45145.1
BC058273 mRNA Translation: AAH58273.1
CCDSiCCDS18432.1
RefSeqiNP_083841.4, NM_029565.3
UniGeneiMm.291192

Genome annotation databases

EnsembliENSMUST00000030361; ENSMUSP00000030361; ENSMUSG00000028618
GeneIDi56374
KEGGimmu:56374
UCSCiuc008tzj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116911 mRNA Translation: AAF20283.1
AK003252 mRNA Translation: BAB22668.2
AK050162 mRNA Translation: BAC34103.1
AK145644 mRNA Translation: BAE26561.1
AK159761 mRNA Translation: BAE35352.1
AK166772 mRNA Translation: BAE39008.1
AK167058 mRNA Translation: BAE39221.1
BC002164 mRNA Translation: AAH02164.1
BC014732 mRNA Translation: AAH14732.1
BC018379 mRNA Translation: AAH18379.1
BC045145 mRNA Translation: AAH45145.1
BC058273 mRNA Translation: AAH58273.1
CCDSiCCDS18432.1
RefSeqiNP_083841.4, NM_029565.3
UniGeneiMm.291192

3D structure databases

ProteinModelPortaliQ9QY73
SMRiQ9QY73
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030361

PTM databases

iPTMnetiQ9QY73
PhosphoSitePlusiQ9QY73
SwissPalmiQ9QY73

Proteomic databases

EPDiQ9QY73
MaxQBiQ9QY73
PaxDbiQ9QY73
PeptideAtlasiQ9QY73
PRIDEiQ9QY73

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030361; ENSMUSP00000030361; ENSMUSG00000028618
GeneIDi56374
KEGGimmu:56374
UCSCiuc008tzj.2 mouse

Organism-specific databases

CTDi9528
MGIiMGI:1929278 Tmem59

Phylogenomic databases

eggNOGiENOG410IIST Eukaryota
ENOG410XTCW LUCA
GeneTreeiENSGT00390000008279
HOGENOMiHOG000015759
HOVERGENiHBG018206
InParanoidiQ9QY73
OMAiQEPTNLK
OrthoDBiEOG091G0EVN
PhylomeDBiQ9QY73
TreeFamiTF331226

Miscellaneous databases

PROiPR:Q9QY73
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028618 Expressed in 108 organ(s), highest expression level in female gonad
CleanExiMM_TMEM59
ExpressionAtlasiQ9QY73 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR022065 Uncharacterised_TMEM59
PANTHERiPTHR28652 PTHR28652, 1 hit
PfamiView protein in Pfam
PF12280 BSMAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM59_MOUSE
AccessioniPrimary (citable) accession number: Q9QY73
Secondary accession number(s): Q3TWB4, Q99LY8, Q9D1P9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: September 12, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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