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Protein

Tetraspanin-3

Gene

Tspan3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-3
Short name:
Tspan-3
Alternative name(s):
OSP-associated protein 1
Short name:
OAP-1
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
Gene namesi
Name:Tspan3
Synonyms:Tm4sf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1928098 Tspan3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 50ExtracellularSequence analysisAdd BLAST18
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 85CytoplasmicSequence analysisAdd BLAST14
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 212ExtracellularSequence analysisAdd BLAST106
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192401 – 253Tetraspanin-3Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QY33
PRIDEiQ9QY33

PTM databases

iPTMnetiQ9QY33
PhosphoSitePlusiQ9QY33
SwissPalmiQ9QY33

Expressioni

Gene expression databases

BgeeiENSMUSG00000032324 Expressed in 276 organ(s), highest expression level in hypothalamus
CleanExiMM_TSPAN3
ExpressionAtlasiQ9QY33 baseline and differential
GenevisibleiQ9QY33 MM

Interactioni

Subunit structurei

Interacts with claudin-11/CLDN11 and integrins.1 Publication

Protein-protein interaction databases

CORUMiQ9QY33
STRINGi10090.ENSMUSP00000034876

Structurei

3D structure databases

ProteinModelPortaliQ9QY33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230654
HOVERGENiHBG104967
InParanoidiQ9QY33
KOiK17293
OMAiDLYSEGC
OrthoDBiEOG091G0INM
PhylomeDBiQ9QY33
TreeFamiTF316345

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QY33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT
60 70 80 90 100
LFPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVFIL LLVFVTEVVV
110 120 130 140 150
VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN SDAASRAIDY VQRQLHCCGI
160 170 180 190 200
HNYSDWENTD WFKETKNQSV PLSCCRETAK SCNGSLANPS DLYAEGCEAL
210 220 230 240 250
VVKKLQEILM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG

TYA
Length:253
Mass (Da):28,049
Last modified:May 1, 2000 - v1
Checksum:i8A7378F76263019A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQ19A0A1L1SQ19_MOUSE
Tetraspanin
Tspan3
201Annotation score:
A0A1L1SRJ4A0A1L1SRJ4_MOUSE
Tetraspanin
Tspan3
256Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220A → R in AAG49145 (PubMed:11309411).Curated1
Sequence conflicti226G → A in AAG49145 (PubMed:11309411).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133427 mRNA Translation: AAF15362.1
AF242591 mRNA Translation: AAG49145.1
CCDSiCCDS23207.1
RefSeqiNP_062767.3, NM_019793.3
UniGeneiMm.28484

Genome annotation databases

EnsembliENSMUST00000034876; ENSMUSP00000034876; ENSMUSG00000032324
GeneIDi56434
KEGGimmu:56434
UCSCiuc009psx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133427 mRNA Translation: AAF15362.1
AF242591 mRNA Translation: AAG49145.1
CCDSiCCDS23207.1
RefSeqiNP_062767.3, NM_019793.3
UniGeneiMm.28484

3D structure databases

ProteinModelPortaliQ9QY33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ9QY33
STRINGi10090.ENSMUSP00000034876

PTM databases

iPTMnetiQ9QY33
PhosphoSitePlusiQ9QY33
SwissPalmiQ9QY33

Proteomic databases

PaxDbiQ9QY33
PRIDEiQ9QY33

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034876; ENSMUSP00000034876; ENSMUSG00000032324
GeneIDi56434
KEGGimmu:56434
UCSCiuc009psx.2 mouse

Organism-specific databases

CTDi10099
MGIiMGI:1928098 Tspan3

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230654
HOVERGENiHBG104967
InParanoidiQ9QY33
KOiK17293
OMAiDLYSEGC
OrthoDBiEOG091G0INM
PhylomeDBiQ9QY33
TreeFamiTF316345

Miscellaneous databases

ChiTaRSiTspan3 mouse
PROiPR:Q9QY33
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032324 Expressed in 276 organ(s), highest expression level in hypothalamus
CleanExiMM_TSPAN3
ExpressionAtlasiQ9QY33 baseline and differential
GenevisibleiQ9QY33 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY33
Secondary accession number(s): Q9EQG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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