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Protein

Zinc finger protein SNAI3

Gene

Snai3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 169C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein SNAI3
Alternative name(s):
Protein snail homolog 3
Snail-related gene from muscle cells
Zinc finger protein 293
Gene namesi
Name:Snai3
Synonyms:Smuc, Zfp293
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1353563 Snai3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300381 – 287Zinc finger protein SNAI3Add BLAST287

Proteomic databases

PaxDbiQ9QY31
PRIDEiQ9QY31

PTM databases

PhosphoSitePlusiQ9QY31

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and thymus. Lower expression in heart, lung and spleen.1 Publication

Developmental stagei

Expressed at E7, higher expression observed in stages E15 and E18.1 Publication

Gene expression databases

BgeeiENSMUSG00000006587 Expressed in 86 organ(s), highest expression level in oocyte
GenevisibleiQ9QY31 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006762

Structurei

3D structure databases

ProteinModelPortaliQ9QY31
SMRiQ9QY31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Domaini

Binds E-box via C2H2-type zinc finger domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 169C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiQ9QY31
KOiK09217
OMAiEINGACS
OrthoDBiEOG091G0Q0V
PhylomeDBiQ9QY31
TreeFamiTF315515

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q9QY31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSFLVKTH SSHRVPNYGK LETLREANGS CSACKELAGS RHLPDEEAPC
60 70 80 90 100
NPSDPLQPWD STSAVACISL PLLPNHRETL GVSGPEPQET SWVGPRAAQA
110 120 130 140 150
PSVTLKDSFT LPPLLVLPTR WPPILGPDGA LNEHLRAEGT SRVPGSFECI
160 170 180 190 200
HCHRPYHTLA GLARHQQLHC HLPTGRAFTC RYCDKEYASL GALKMHIRTH
210 220 230 240 250
TLPCICKVCG KAFSRPWLLQ GHIRTHTGEK PYTCSHCSRA FADRSNLRAH
260 270 280
LQTHVGTKKY RCAVCPKAFS RMSLLARHEE AGCCPGP
Length:287
Mass (Da):31,636
Last modified:May 1, 2000 - v1
Checksum:i02E42A6FE8BAFD48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75N → S in AAI00727 (PubMed:15489334).Curated1
Sequence conflicti169H → Y in BAC40828 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133714 mRNA Translation: AAF22956.1
AF195655 mRNA Translation: AAQ13827.1
AK042234 mRNA Translation: BAC31201.1
AK089285 mRNA Translation: BAC40828.1
AK153633 mRNA Translation: BAE32128.1
AK154585 mRNA Translation: BAE32693.1
BC100724 mRNA Translation: AAI00725.1
BC100726 mRNA Translation: AAI00727.1
BC100727 mRNA Translation: AAI00728.1
CCDSiCCDS22739.1
RefSeqiNP_038942.1, NM_013914.2
UniGeneiMm.103673

Genome annotation databases

EnsembliENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587
GeneIDi30927
KEGGimmu:30927
UCSCiuc009nsw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133714 mRNA Translation: AAF22956.1
AF195655 mRNA Translation: AAQ13827.1
AK042234 mRNA Translation: BAC31201.1
AK089285 mRNA Translation: BAC40828.1
AK153633 mRNA Translation: BAE32128.1
AK154585 mRNA Translation: BAE32693.1
BC100724 mRNA Translation: AAI00725.1
BC100726 mRNA Translation: AAI00727.1
BC100727 mRNA Translation: AAI00728.1
CCDSiCCDS22739.1
RefSeqiNP_038942.1, NM_013914.2
UniGeneiMm.103673

3D structure databases

ProteinModelPortaliQ9QY31
SMRiQ9QY31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006762

PTM databases

PhosphoSitePlusiQ9QY31

Proteomic databases

PaxDbiQ9QY31
PRIDEiQ9QY31

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587
GeneIDi30927
KEGGimmu:30927
UCSCiuc009nsw.1 mouse

Organism-specific databases

CTDi333929
MGIiMGI:1353563 Snai3

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiQ9QY31
KOiK09217
OMAiEINGACS
OrthoDBiEOG091G0Q0V
PhylomeDBiQ9QY31
TreeFamiTF315515

Miscellaneous databases

PROiPR:Q9QY31
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006587 Expressed in 86 organ(s), highest expression level in oocyte
GenevisibleiQ9QY31 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNAI3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY31
Secondary accession number(s): Q3U3U2, Q496S5, Q8C244
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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