Snai3

Functionⁱ

Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	147 – 169	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	178 – 200	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	204 – 226	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	232 – 254	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	260 – 282	C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 10606664
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 10606664
metal ion binding Source: UniProtKB-KW
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 16735694
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10606664
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 16735694

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 10606664
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 10606664
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 16735694

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein SNAI3 Alternative name(s): Protein snail homolog 3 Snail-related gene from muscle cells Zinc finger protein 293
Gene namesⁱ	Name:Snai3 Synonyms:Smuc, Zfp293
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1353563 Snai3

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000330038	1 – 287	Zinc finger protein SNAI3Add BLAST		287

Proteomic databases

PaxDbⁱ	Q9QY31
PRIDEⁱ	Q9QY31

PTM databases

PhosphoSitePlusⁱ	Q9QY31

PhosphoSitePlusⁱ

Q9QY31

Expressionⁱ

Tissue specificityⁱ

Highly expressed in skeletal muscle and thymus. Lower expression in heart, lung and spleen.1 Publication

Developmental stageⁱ

Expressed at E7, higher expression observed in stages E15 and E18.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000006587 Expressed in 86 organ(s), highest expression level in oocyte
Genevisibleⁱ	Q9QY31 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000006762

STRINGⁱ

10090.ENSMUSP00000006762

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QY31
SMRⁱ	Q9QY31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST		20

Domainⁱ

Binds E-box via C2H2-type zinc finger domain.

Sequence similaritiesⁱ

Belongs to the snail C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	147 – 169	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	178 – 200	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	204 – 226	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	232 – 254	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	260 – 282	C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q9QY31
KEGG Orthology (KO) More...KOⁱ	K09217
OMAⁱ	EINGACS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q9QY31
TreeFamⁱ	TF315515

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9QY31-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRSFLVKTH SSHRVPNYGK LETLREANGS CSACKELAGS RHLPDEEAPC 
        60         70         80         90        100
NPSDPLQPWD STSAVACISL PLLPNHRETL GVSGPEPQET SWVGPRAAQA 
       110        120        130        140        150
PSVTLKDSFT LPPLLVLPTR WPPILGPDGA LNEHLRAEGT SRVPGSFECI 
       160        170        180        190        200
HCHRPYHTLA GLARHQQLHC HLPTGRAFTC RYCDKEYASL GALKMHIRTH 
       210        220        230        240        250
TLPCICKVCG KAFSRPWLLQ GHIRTHTGEK PYTCSHCSRA FADRSNLRAH 
       260        270        280 
LQTHVGTKKY RCAVCPKAFS RMSLLARHEE AGCCPGP

Length:287

Mass (Da):31,636

Last modified:May 1, 2000 - v1

Checksum:ⁱ02E42A6FE8BAFD48

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	75	N → S in AAI00727 (PubMed:15489334).Curated		1
Sequence conflictⁱ	169	H → Y in BAC40828 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF133714 mRNA Translation: AAF22956.1 AF195655 mRNA Translation: AAQ13827.1 AK042234 mRNA Translation: BAC31201.1 AK089285 mRNA Translation: BAC40828.1 AK153633 mRNA Translation: BAE32128.1 AK154585 mRNA Translation: BAE32693.1 BC100724 mRNA Translation: AAI00725.1 BC100726 mRNA Translation: AAI00727.1 BC100727 mRNA Translation: AAI00728.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22739.1
NCBI Reference Sequences More...RefSeqⁱ	NP_038942.1, NM_013914.2
UniGeneⁱ	Mm.103673

Genome annotation databases

Ensemblⁱ	ENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587
GeneIDⁱ	30927
KEGGⁱ	mmu:30927
UCSC genome browser More...UCSCⁱ	uc009nsw.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QY31	Zinc finger protein SNAI3		HUMAN		292	UniRef50_Q9QY31
Snail family transcriptional repressor 3		MONDO		296
Zinc finger protein SNAI3		FUKDA		334
Snail family transcriptional repressor 3		RAT		287
Zinc finger protein SNAI3		CRIGR		195
+42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF133714 mRNA Translation: AAF22956.1 AF195655 mRNA Translation: AAQ13827.1 AK042234 mRNA Translation: BAC31201.1 AK089285 mRNA Translation: BAC40828.1 AK153633 mRNA Translation: BAE32128.1 AK154585 mRNA Translation: BAE32693.1 BC100724 mRNA Translation: AAI00725.1 BC100726 mRNA Translation: AAI00727.1 BC100727 mRNA Translation: AAI00728.1
CCDSⁱ	CCDS22739.1
RefSeqⁱ	NP_038942.1, NM_013914.2
UniGeneⁱ	Mm.103673

3D structure databases

ProteinModelPortalⁱ	Q9QY31
SMRⁱ	Q9QY31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000006762

STRINGⁱ

10090.ENSMUSP00000006762

PTM databases

PhosphoSitePlusⁱ	Q9QY31

PhosphoSitePlusⁱ

Q9QY31

Proteomic databases

PaxDbⁱ	Q9QY31
PRIDEⁱ	Q9QY31

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587
GeneIDⁱ	30927
KEGGⁱ	mmu:30927
UCSCⁱ	uc009nsw.1 mouse

Organism-specific databases

CTDⁱ	333929
MGIⁱ	MGI:1353563 Snai3

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q9QY31
KOⁱ	K09217
OMAⁱ	EINGACS
OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q9QY31
TreeFamⁱ	TF315515

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9QY31
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000006587 Expressed in 86 organ(s), highest expression level in oocyte
Genevisibleⁱ	Q9QY31 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNAI3_MOUSE
Accessionⁱ	Q9QY31Primary (citable) accession number: Q9QY31 Secondary accession number(s): Q3U3U2, Q496S5, Q8C244
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QY31 (SNAI3_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger protein SNAI3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ