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UniProtKB - Q9QY31 (SNAI3_MOUSE)
Protein
Zinc finger protein SNAI3
Gene
Snai3
Organism
Mus musculus (Mouse)
Status
Functioni
Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 147 – 169 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 178 – 200 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 204 – 226 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 254 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein SNAI3Alternative name(s): Protein snail homolog 3 Snail-related gene from muscle cells Zinc finger protein 293 |
Gene namesi | Name:Snai3 Synonyms:Smuc, Zfp293 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353563, Snai3 |
VEuPathDBi | HostDB:ENSMUSG00000006587 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: MGI
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000330038 | 1 – 287 | Zinc finger protein SNAI3Add BLAST | 287 |
Proteomic databases
PaxDbi | Q9QY31 |
PRIDEi | Q9QY31 |
ProteomicsDBi | 261591 |
PTM databases
PhosphoSitePlusi | Q9QY31 |
Expressioni
Tissue specificityi
Highly expressed in skeletal muscle and thymus. Lower expression in heart, lung and spleen.1 Publication
Developmental stagei
Expressed at 7 dpc, higher expression observed in stages 15 dpc and 18 dpc.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000006587, Expressed in oocyte and 128 other tissues |
Genevisiblei | Q9QY31, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000006762 |
Miscellaneous databases
RNActi | Q9QY31, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | SNAG domainBy similarityAdd BLAST | 20 |
Domaini
Binds E-box via C2H2-type zinc finger domain.
Sequence similaritiesi
Belongs to the snail C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 147 – 169 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 178 – 200 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 204 – 226 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 254 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154511 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | Q9QY31 |
OMAi | PWDRSSA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9QY31 |
TreeFami | TF315515 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
Q9QY31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRSFLVKTH SSHRVPNYGK LETLREANGS CSACKELAGS RHLPDEEAPC
60 70 80 90 100
NPSDPLQPWD STSAVACISL PLLPNHRETL GVSGPEPQET SWVGPRAAQA
110 120 130 140 150
PSVTLKDSFT LPPLLVLPTR WPPILGPDGA LNEHLRAEGT SRVPGSFECI
160 170 180 190 200
HCHRPYHTLA GLARHQQLHC HLPTGRAFTC RYCDKEYASL GALKMHIRTH
210 220 230 240 250
TLPCICKVCG KAFSRPWLLQ GHIRTHTGEK PYTCSHCSRA FADRSNLRAH
260 270 280
LQTHVGTKKY RCAVCPKAFS RMSLLARHEE AGCCPGP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 | N → S in AAI00727 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 169 | H → Y in BAC40828 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133714 mRNA Translation: AAF22956.1 AF195655 mRNA Translation: AAQ13827.1 AK042234 mRNA Translation: BAC31201.1 AK089285 mRNA Translation: BAC40828.1 AK153633 mRNA Translation: BAE32128.1 AK154585 mRNA Translation: BAE32693.1 BC100724 mRNA Translation: AAI00725.1 BC100726 mRNA Translation: AAI00727.1 BC100727 mRNA Translation: AAI00728.1 |
CCDSi | CCDS22739.1 |
RefSeqi | NP_038942.1, NM_013914.2 |
Genome annotation databases
Ensembli | ENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587 |
GeneIDi | 30927 |
KEGGi | mmu:30927 |
UCSCi | uc009nsw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133714 mRNA Translation: AAF22956.1 AF195655 mRNA Translation: AAQ13827.1 AK042234 mRNA Translation: BAC31201.1 AK089285 mRNA Translation: BAC40828.1 AK153633 mRNA Translation: BAE32128.1 AK154585 mRNA Translation: BAE32693.1 BC100724 mRNA Translation: AAI00725.1 BC100726 mRNA Translation: AAI00727.1 BC100727 mRNA Translation: AAI00728.1 |
CCDSi | CCDS22739.1 |
RefSeqi | NP_038942.1, NM_013914.2 |
3D structure databases
SMRi | Q9QY31 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000006762 |
PTM databases
PhosphoSitePlusi | Q9QY31 |
Proteomic databases
PaxDbi | Q9QY31 |
PRIDEi | Q9QY31 |
ProteomicsDBi | 261591 |
Protocols and materials databases
Antibodypediai | 17289, 129 antibodies from 26 providers |
DNASUi | 30927 |
Genome annotation databases
Ensembli | ENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587 |
GeneIDi | 30927 |
KEGGi | mmu:30927 |
UCSCi | uc009nsw.1, mouse |
Organism-specific databases
CTDi | 333929 |
MGIi | MGI:1353563, Snai3 |
VEuPathDBi | HostDB:ENSMUSG00000006587 |
Phylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154511 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | Q9QY31 |
OMAi | PWDRSSA |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9QY31 |
TreeFami | TF315515 |
Miscellaneous databases
BioGRID-ORCSi | 30927, 1 hit in 63 CRISPR screens |
ChiTaRSi | Snai3, mouse |
PROi | PR:Q9QY31 |
RNActi | Q9QY31, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006587, Expressed in oocyte and 128 other tissues |
Genevisiblei | Q9QY31, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SNAI3_MOUSE | |
Accessioni | Q9QY31Primary (citable) accession number: Q9QY31 Secondary accession number(s): Q3U3U2, Q496S5, Q8C244 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families