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Protein

Plakophilin-3

Gene

Pkp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in junctional plaques.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-3
Gene namesi
Name:Pkp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891830 Pkp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642881 – 797Plakophilin-3Add BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Omega-N-methylarginineBy similarity1
Modified residuei123PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei183PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei250PhosphothreonineBy similarity1
Modified residuei261Omega-N-methylarginineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei331PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QY23
PeptideAtlasiQ9QY23
PRIDEiQ9QY23

PTM databases

iPTMnetiQ9QY23
PhosphoSitePlusiQ9QY23

Expressioni

Gene expression databases

BgeeiENSMUSG00000054065 Expressed in 184 organ(s), highest expression level in zone of skin
CleanExiMM_PKP3
ExpressionAtlasiQ9QY23 baseline and differential
GenevisibleiQ9QY23 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QY23, 2 interactors
STRINGi10090.ENSMUSP00000101654

Structurei

3D structure databases

ProteinModelPortaliQ9QY23
SMRiQ9QY23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati305 – 348ARM 1Add BLAST44
Repeati351 – 390ARM 2Add BLAST40
Repeati393 – 432ARM 3Add BLAST40
Repeati449 – 487ARM 4Add BLAST39
Repeati491 – 536ARM 5Add BLAST46
Repeati596 – 637ARM 6Add BLAST42
Repeati645 – 684ARM 7Add BLAST40
Repeati689 – 730ARM 8Add BLAST42

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOGENOMiHOG000115567
HOVERGENiHBG106682
InParanoidiQ9QY23
OMAiNARNKDE
OrthoDBiEOG091G01WL
PhylomeDBiQ9QY23
TreeFamiTF321877

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028434 Plakophilin-3
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF1 PTHR10372:SF1, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 4 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QY23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQEGNFLLSA LQPETGVCSL ALPSDLQLDR RGAEGPEADR LRAARVQEQV
60 70 80 90 100
RARLLQLGQQ SRHNGSAELD GSAESARGMP RGQYHTMQTG FSSRSQGMSG
110 120 130 140 150
DKTSTFRPIA KPAYSPASWS SRSAVDLTCS RRLSSAHNGG SAFGAVGYGG
160 170 180 190 200
TQPTPPMPTR PVSFHERGGA ASRADYDTLS LRSLRLGPGG LDDRYSVVSE
210 220 230 240 250
QLEPAAASTY RAYAYERQAS SGSSRAGGLD WPEATEGPPS RTIRAPAMRT
260 270 280 290 300
LQRFQSSHRS RGGTGSVSGA GLEPVARAPS VRSLSLSLAD SGHLPDVRGL
310 320 330 340 350
DSYTGHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHRCYSD
360 370 380 390 400
AAAKKQARSL QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNVDNKLALV
410 420 430 440 450
EENGIFELLR TLREQDDELR KNVTGILWNL SSSDHLKDRL ARDTLEQLTD
460 470 480 490 500
LVLSPLSGAG GPPLIQQNAS EAEIFYNATG FLRNLSSASQ ATRQKMRECH
510 520 530 540 550
GLVDALVTYI NHALDVGKCE DKSVENAVCV LRNLSYRLYD EMPPSALQRL
560 570 580 590 600
EGRGRRDMAG APPGEMVGCF TPQSRRLREL PLTADALTFA EVSKDPKGLE
610 620 630 640 650
WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA
660 670 680 690 700
LEQERILNPL LDRVRTADHN QLRSLTGLIR NLSRNARNKD EMSTKVVSHL
710 720 730 740 750
IEKLPGSVGE KCPPAEVLVN IIAVLNNLVV ASPIAARDLL YFDGLRKLVF
760 770 780 790
IKKKRDSPDS EKSSRAASSL LANLWQYSKL HRDFRAKGYR KEDFLGP
Length:797
Mass (Da):87,333
Last modified:June 12, 2007 - v2
Checksum:iC2ECF73BDE7323B1
GO
Isoform 2 (identifier: Q9QY23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MQEGNFLLSALQ → MEPTAGSRTRMEPRRNCPTAGTSRMSQGASGGQTSGK

Note: No experimental confirmation available.
Show »
Length:822
Mass (Da):89,822
Checksum:i2FF8611C988EB4D0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CY75E0CY75_MOUSE
Plakophilin-3
Pkp3
215Annotation score:
E0CYP0E0CYP0_MOUSE
Plakophilin-3
Pkp3
87Annotation score:
E0CY06E0CY06_MOUSE
Plakophilin-3
Pkp3
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182R → P in AAD55892 (PubMed:10381383).Curated1
Sequence conflicti216E → K in AAD55892 (PubMed:10381383).Curated1
Sequence conflicti459A → P in AAD55892 (PubMed:10381383).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0261391 – 12MQEGN…LSALQ → MEPTAGSRTRMEPRRNCPTA GTSRMSQGASGGQTSGK in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136719 mRNA Translation: AAD55892.1
BC090668 mRNA Translation: AAH90668.1
BC106141 mRNA Translation: AAI06142.1
BC139775 mRNA Translation: AAI39776.1
CCDSiCCDS21999.1 [Q9QY23-1]
CCDS52437.1 [Q9QY23-2]
RefSeqiNP_001156396.1, NM_001162924.1 [Q9QY23-2]
NP_062736.2, NM_019762.2 [Q9QY23-1]
UniGeneiMm.350037

Genome annotation databases

EnsembliENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065 [Q9QY23-1]
ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065 [Q9QY23-2]
GeneIDi56460
KEGGimmu:56460
UCSCiuc009kjh.2 mouse [Q9QY23-2]
uc009kji.2 mouse [Q9QY23-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136719 mRNA Translation: AAD55892.1
BC090668 mRNA Translation: AAH90668.1
BC106141 mRNA Translation: AAI06142.1
BC139775 mRNA Translation: AAI39776.1
CCDSiCCDS21999.1 [Q9QY23-1]
CCDS52437.1 [Q9QY23-2]
RefSeqiNP_001156396.1, NM_001162924.1 [Q9QY23-2]
NP_062736.2, NM_019762.2 [Q9QY23-1]
UniGeneiMm.350037

3D structure databases

ProteinModelPortaliQ9QY23
SMRiQ9QY23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QY23, 2 interactors
STRINGi10090.ENSMUSP00000101654

PTM databases

iPTMnetiQ9QY23
PhosphoSitePlusiQ9QY23

Proteomic databases

PaxDbiQ9QY23
PeptideAtlasiQ9QY23
PRIDEiQ9QY23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065 [Q9QY23-1]
ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065 [Q9QY23-2]
GeneIDi56460
KEGGimmu:56460
UCSCiuc009kjh.2 mouse [Q9QY23-2]
uc009kji.2 mouse [Q9QY23-1]

Organism-specific databases

CTDi11187
MGIiMGI:1891830 Pkp3

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOGENOMiHOG000115567
HOVERGENiHBG106682
InParanoidiQ9QY23
OMAiNARNKDE
OrthoDBiEOG091G01WL
PhylomeDBiQ9QY23
TreeFamiTF321877

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiPkp3 mouse
PROiPR:Q9QY23
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054065 Expressed in 184 organ(s), highest expression level in zone of skin
CleanExiMM_PKP3
ExpressionAtlasiQ9QY23 baseline and differential
GenevisibleiQ9QY23 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028434 Plakophilin-3
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF1 PTHR10372:SF1, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 4 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKP3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY23
Secondary accession number(s): A4QPD8, Q0VGP3, Q3KQL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 12, 2007
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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