UniProtKB - Q9QY14 (FOXE3_MOUSE)
Protein
Forkhead box protein E3
Gene
Foxe3
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278). Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity).By similarity4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 64 – 158 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- camera-type eye development Source: MGI
- cell development Source: MGI
- cell differentiation Source: GO_Central
- ciliary body morphogenesis Source: UniProtKB
- cornea development in camera-type eye Source: UniProtKB
- eye development Source: MGI
- iris morphogenesis Source: UniProtKB
- lens development in camera-type eye Source: UniProtKB
- mRNA transcription by RNA polymerase II Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cell cycle arrest Source: UniProtKB
- negative regulation of lens fiber cell differentiation Source: UniProtKB
- positive regulation of epithelial cell proliferation Source: MGI
- positive regulation of lens epithelial cell proliferation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- trabecular meshwork development Source: UniProtKB
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein E3 |
Gene namesi | Name:Foxe3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353569, Foxe3 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens.2 Publications
Disruption phenotypei
Knockout mice are viable and fertile but show eye abnormalities; in some cases the eyes never open. Eyes are much smaller, the anterior chamber is not formed, and the pupil is markedly smaller. There are no abnormalities in brain development (PubMed:16199865). Mice show reduced smooth muscle cell (SMC) density and impaired SMC differentiation that is limited to the ascending aorta (PubMed:26854927).2 Publications
Keywords - Diseasei
Disease mutationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091830 | 1 – 288 | Forkhead box protein E3Add BLAST | 288 |
Proteomic databases
PaxDbi | Q9QY14 |
PRIDEi | Q9QY14 |
PTM databases
PhosphoSitePlusi | Q9QY14 |
Expressioni
Tissue specificityi
Expressed in the embryonic lens.3 Publications
Developmental stagei
Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins.3 Publications
Inductioni
Head ectoderm expression is induced by RAX and lens expression is induced by PAX6.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000044518, Expressed in lens of camera-type eye and 42 other tissues |
Genevisiblei | Q9QY14, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 206001, 2 interactors |
STRINGi | 10090.ENSMUSP00000050445 |
Miscellaneous databases
RNActi | Q9QY14, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 166 – 254 | Pro-richPROSITE-ProRule annotationAdd BLAST | 89 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000163987 |
HOGENOMi | CLU_023357_0_1_1 |
InParanoidi | Q9QY14 |
OMAi | PEPPCCA |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q9QY14 |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9QY14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP
60 70 80 90 100
GPGKRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF
110 120 130 140 150
YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN
160 170 180 190 200
GSFLRRRKRF KRAELPAPPP PPPPFPYAPF PPPPAPASAP PARLFRLDSL
210 220 230 240 250
LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA SERLGLPAPL
260 270 280
PAQPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 93 | F → L in dyl; negative regulation of lens epithelial cell proliferation; positive regulation of lens fiber cell differentiation; positive regulation of epithelial cell apoptotic process; loss of sequence-specific DNA binding. 3 Publications | 1 | |
Natural varianti | 98 | F → S in dyl; negative regulation of lens epithelial cell proliferation; positive regulation of lens fiber cell differentiation; positive regulation of epithelial cell apoptotic process; loss of sequence-specific DNA binding. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF142647 Genomic DNA Translation: AAF15997.1 |
CCDSi | CCDS18483.1 |
RefSeqi | NP_056573.1, NM_015758.2 |
Genome annotation databases
Ensembli | ENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518 |
GeneIDi | 30923 |
KEGGi | mmu:30923 |
UCSCi | uc008uef.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF142647 Genomic DNA Translation: AAF15997.1 |
CCDSi | CCDS18483.1 |
RefSeqi | NP_056573.1, NM_015758.2 |
3D structure databases
SMRi | Q9QY14 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 206001, 2 interactors |
STRINGi | 10090.ENSMUSP00000050445 |
PTM databases
PhosphoSitePlusi | Q9QY14 |
Proteomic databases
PaxDbi | Q9QY14 |
PRIDEi | Q9QY14 |
Protocols and materials databases
Antibodypediai | 18909, 204 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518 |
GeneIDi | 30923 |
KEGGi | mmu:30923 |
UCSCi | uc008uef.1, mouse |
Organism-specific databases
CTDi | 2301 |
MGIi | MGI:1353569, Foxe3 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000163987 |
HOGENOMi | CLU_023357_0_1_1 |
InParanoidi | Q9QY14 |
OMAi | PEPPCCA |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q9QY14 |
TreeFami | TF316127 |
Miscellaneous databases
BioGRID-ORCSi | 30923, 3 hits in 17 CRISPR screens |
PROi | PR:Q9QY14 |
RNActi | Q9QY14, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000044518, Expressed in lens of camera-type eye and 42 other tissues |
Genevisiblei | Q9QY14, MM |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXE3_MOUSE | |
Accessioni | Q9QY14Primary (citable) accession number: Q9QY14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot