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Protein

Insulin-like peptide INSL6

Gene

Insl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in sperm development and fertilization.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like peptide INSL6
Short name:
Insulin-like peptide 6
Cleaved into the following 2 chains:
Gene namesi
Name:Insl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1351595 Insl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001617723 – 191Insulin-like peptide INSL6Add BLAST169
PeptideiPRO_000001617823 – 51Insulin-like peptide INSL6 B chainSequence analysisAdd BLAST29
PropeptideiPRO_000001617953 – 161Connecting peptideSequence analysisAdd BLAST109
PeptideiPRO_0000016180166 – 191Insulin-like peptide INSL6 A chainSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 172By similarity
Disulfide bondi45 ↔ 185By similarity
Disulfide bondi171 ↔ 176By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9QY05
PRIDEiQ9QY05

PTM databases

iPTMnetiQ9QY05
PhosphoSitePlusiQ9QY05

Expressioni

Gene expression databases

BgeeiENSMUSG00000050957 Expressed in 145 organ(s), highest expression level in testis
CleanExiMM_INSL6
ExpressionAtlasiQ9QY05 baseline and differential
GenevisibleiQ9QY05 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054488

Structurei

3D structure databases

ProteinModelPortaliQ9QY05
SMRiQ9QY05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9YE Eukaryota
ENOG41117BC LUCA
GeneTreeiENSGT00510000049111
HOGENOMiHOG000113078
HOVERGENiHBG052136
InParanoidiQ9QY05
KOiK05255
OMAiFWGNHPQ
OrthoDBiEOG091G0SQ8
PhylomeDBiQ9QY05
TreeFamiTF343788

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR017100 Insulin-like_pep_6
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
PANTHERiPTHR12004:SF1 PTHR12004:SF1, 1 hit
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PIRSFiPIRSF037062 Insulin-like_peptide_6, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 2 hits
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QY05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQLCCSCLL WLGLLLTPFS REEEEESRPR KLCGRHLLIE VIKLCGQSDW
60 70 80 90 100
SRFEMEEQSP MTQFFPHYSR KGKAFNPHPS SSAWRRFTNP VPAGVSQKKG
110 120 130 140 150
THTWEPQSLP DYQFEKTELL PKARVFSYHS GKPYVKSVQL QKKSTNKMNT
160 170 180 190
FRSLFWGNHS QRKRRGFADK CCVIGCTKEE MAVACLPFVD F
Length:191
Mass (Da):22,215
Last modified:May 1, 2000 - v1
Checksum:iB47FFE245F031190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143807 mRNA Translation: AAD30158.2
BC028752 mRNA Translation: AAH28752.1
CCDSiCCDS29732.1
RefSeqiNP_038782.1, NM_013754.1
UniGeneiMm.306511

Genome annotation databases

EnsembliENSMUST00000052380; ENSMUSP00000054488; ENSMUSG00000050957
GeneIDi27356
KEGGimmu:27356
UCSCiuc008hdd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143807 mRNA Translation: AAD30158.2
BC028752 mRNA Translation: AAH28752.1
CCDSiCCDS29732.1
RefSeqiNP_038782.1, NM_013754.1
UniGeneiMm.306511

3D structure databases

ProteinModelPortaliQ9QY05
SMRiQ9QY05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054488

PTM databases

iPTMnetiQ9QY05
PhosphoSitePlusiQ9QY05

Proteomic databases

PaxDbiQ9QY05
PRIDEiQ9QY05

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052380; ENSMUSP00000054488; ENSMUSG00000050957
GeneIDi27356
KEGGimmu:27356
UCSCiuc008hdd.1 mouse

Organism-specific databases

CTDi11172
MGIiMGI:1351595 Insl6

Phylogenomic databases

eggNOGiENOG410J9YE Eukaryota
ENOG41117BC LUCA
GeneTreeiENSGT00510000049111
HOGENOMiHOG000113078
HOVERGENiHBG052136
InParanoidiQ9QY05
KOiK05255
OMAiFWGNHPQ
OrthoDBiEOG091G0SQ8
PhylomeDBiQ9QY05
TreeFamiTF343788

Miscellaneous databases

PROiPR:Q9QY05
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050957 Expressed in 145 organ(s), highest expression level in testis
CleanExiMM_INSL6
ExpressionAtlasiQ9QY05 baseline and differential
GenevisibleiQ9QY05 MM

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR017100 Insulin-like_pep_6
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
PANTHERiPTHR12004:SF1 PTHR12004:SF1, 1 hit
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PIRSFiPIRSF037062 Insulin-like_peptide_6, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 2 hits
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINSL6_MOUSE
AccessioniPrimary (citable) accession number: Q9QY05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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