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Protein

Nuclear fragile X mental retardation-interacting protein 1

Gene

Nufip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds RNA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • ATPase binding Source: MGI
  • identical protein binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • protein binding, bridging Source: MGI
  • RNA binding Source: MGI
  • snoRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fragile X mental retardation-interacting protein 1
Alternative name(s):
Nuclear FMRP-interacting protein 1
Gene namesi
Name:Nufip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1351474 Nufip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455191 – 484Nuclear fragile X mental retardation-interacting protein 1Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QXX8
MaxQBiQ9QXX8
PaxDbiQ9QXX8
PeptideAtlasiQ9QXX8
PRIDEiQ9QXX8

PTM databases

iPTMnetiQ9QXX8
PhosphoSitePlusiQ9QXX8

Expressioni

Tissue specificityi

Expressed in the brain; in neurons and not in glial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000022009 Expressed in 269 organ(s), highest expression level in cleaving embryo
GenevisibleiQ9QXX8 MM

Interactioni

Subunit structurei

Interacts with FMR1 (PubMed:10556305). Interacts with ZNHIT3 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022586

Structurei

3D structure databases

ProteinModelPortaliQ9QXX8
SMRiQ9QXX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi234 – 250Bipartite nuclear localization signalAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 92Pro-richAdd BLAST89

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ6R Eukaryota
ENOG4111GKG LUCA
GeneTreeiENSGT00390000003758
HOGENOMiHOG000113888
HOVERGENiHBG059841
InParanoidiQ9QXX8
OMAiCDFAALH
OrthoDBiEOG091G0OE9
PhylomeDBiQ9QXX8
TreeFamiTF329804

Family and domain databases

InterProiView protein in InterPro
IPR039136 NUFIP1-like
IPR019496 NUFIP1_cons_dom
IPR022755 Znf_C2H2_jaz
IPR013087 Znf_C2H2_type
PANTHERiPTHR13309 PTHR13309, 1 hit
PfamiView protein in Pfam
PF10453 NUFIP1, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPAPAVWP SAPDLTPAPG TPSEAAPPRD NWVYWAMLPP PPPPLSSPVA
60 70 80 90 100
GSEQSRKGQP HVLPQPPSGA LPPFDAQILP AAQPPFDAQA PPDAQSQFSG
110 120 130 140 150
QQAWNLQAST PWYWGLSPNG FSTYHTSYQS PVTHSYFPRS HDAKFNLPQN
160 170 180 190 200
RKQKTKKRKE PVFHFFCDTC DRGFKNQEKY DTHMSEHTKC PEVDCSFSAH
210 220 230 240 250
EKIVQFHWRN MHAPGMKKIK LDTPEEIARW REERRKNYPT LANIERKKKL
260 270 280 290 300
QLEKAKRGEV LTTTQYGKMK GMSRHSQMAK IRSPGKHHKW RRGGARQRAV
310 320 330 340 350
VGLGNHARDS KPEVPSKANV DPLGALIHSD SESDKEEKAQ RTVVPKEVTP
360 370 380 390 400
ALCSLMSSYG DVSGSDSEPE EAPIKTEAEV LAENHVLHSS PPKSPKQNVQ
410 420 430 440 450
TTGRTVSRSK WENQRNGLRK ISLKRKKSHC HPLFEPRTHH PYLLEMLLAP
460 470 480
DIRHERNVIL QCVRYIIKKD FFGLNTDSVK TEEV
Length:484
Mass (Da):54,713
Last modified:May 1, 2000 - v1
Checksum:iD17E4B099F4EA579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032324 mRNA Translation: BAC27815.1
AK009260 mRNA Translation: BAB26177.1
AK156205 mRNA Translation: BAE33625.1
AF159549 mRNA Translation: AAF15316.1
BC056192 mRNA Translation: AAH56192.1
CCDSiCCDS27284.1
RefSeqiNP_038773.1, NM_013745.5
UniGeneiMm.21138

Genome annotation databases

EnsembliENSMUST00000022586; ENSMUSP00000022586; ENSMUSG00000022009
GeneIDi27275
KEGGimmu:27275
UCSCiuc007ure.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032324 mRNA Translation: BAC27815.1
AK009260 mRNA Translation: BAB26177.1
AK156205 mRNA Translation: BAE33625.1
AF159549 mRNA Translation: AAF15316.1
BC056192 mRNA Translation: AAH56192.1
CCDSiCCDS27284.1
RefSeqiNP_038773.1, NM_013745.5
UniGeneiMm.21138

3D structure databases

ProteinModelPortaliQ9QXX8
SMRiQ9QXX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022586

PTM databases

iPTMnetiQ9QXX8
PhosphoSitePlusiQ9QXX8

Proteomic databases

EPDiQ9QXX8
MaxQBiQ9QXX8
PaxDbiQ9QXX8
PeptideAtlasiQ9QXX8
PRIDEiQ9QXX8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022586; ENSMUSP00000022586; ENSMUSG00000022009
GeneIDi27275
KEGGimmu:27275
UCSCiuc007ure.1 mouse

Organism-specific databases

CTDi26747
MGIiMGI:1351474 Nufip1

Phylogenomic databases

eggNOGiENOG410IJ6R Eukaryota
ENOG4111GKG LUCA
GeneTreeiENSGT00390000003758
HOGENOMiHOG000113888
HOVERGENiHBG059841
InParanoidiQ9QXX8
OMAiCDFAALH
OrthoDBiEOG091G0OE9
PhylomeDBiQ9QXX8
TreeFamiTF329804

Miscellaneous databases

PROiPR:Q9QXX8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022009 Expressed in 269 organ(s), highest expression level in cleaving embryo
GenevisibleiQ9QXX8 MM

Family and domain databases

InterProiView protein in InterPro
IPR039136 NUFIP1-like
IPR019496 NUFIP1_cons_dom
IPR022755 Znf_C2H2_jaz
IPR013087 Znf_C2H2_type
PANTHERiPTHR13309 PTHR13309, 1 hit
PfamiView protein in Pfam
PF10453 NUFIP1, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUFP1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXX8
Secondary accession number(s): Q9CV69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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