Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein jagged-1

Gene

Jag1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • Notch binding Source: UniProtKB
  • phospholipid binding Source: MGI
  • receptor ligand activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein jagged-1
Short name:
Jagged1
Alternative name(s):
CD_antigen: CD339
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Jag1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1095416 Jag1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 1067ExtracellularSequence analysisAdd BLAST1034
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1068 – 1093HelicalSequence analysisAdd BLAST26
Topological domaini1094 – 1218CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000762634 – 1218Protein jagged-1Add BLAST1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi187 ↔ 196By similarity
Disulfide bondi200 ↔ 212By similarity
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi234 ↔ 245By similarity
Disulfide bondi238 ↔ 251By similarity
Disulfide bondi253 ↔ 262By similarity
Disulfide bondi265 ↔ 276By similarity
Disulfide bondi271 ↔ 282By similarity
Disulfide bondi284 ↔ 293By similarity
Disulfide bondi300 ↔ 312By similarity
Disulfide bondi306 ↔ 322By similarity
Disulfide bondi324 ↔ 333By similarity
Disulfide bondi340 ↔ 351By similarity
Disulfide bondi345 ↔ 360By similarity
Disulfide bondi362 ↔ 371By similarity
Disulfide bondi378 ↔ 389By similarity
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi383 ↔ 398By similarity
Disulfide bondi400 ↔ 409By similarity
Disulfide bondi416 ↔ 427By similarity
Disulfide bondi421 ↔ 436By similarity
Disulfide bondi438 ↔ 447By similarity
Disulfide bondi454 ↔ 464By similarity
Disulfide bondi458 ↔ 473By similarity
Disulfide bondi475 ↔ 484By similarity
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi496 ↔ 511By similarity
Disulfide bondi513 ↔ 522By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi534 ↔ 549By similarity
Disulfide bondi551 ↔ 560By similarity
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi578 ↔ 605By similarity
Disulfide bondi599 ↔ 615By similarity
Disulfide bondi617 ↔ 626By similarity
Disulfide bondi633 ↔ 644By similarity
Disulfide bondi638 ↔ 653By similarity
Disulfide bondi655 ↔ 664By similarity
Disulfide bondi671 ↔ 682By similarity
Disulfide bondi676 ↔ 691By similarity
Disulfide bondi693 ↔ 702By similarity
Disulfide bondi709 ↔ 720By similarity
Disulfide bondi714 ↔ 729By similarity
Disulfide bondi731 ↔ 740By similarity
Glycosylationi745N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi748 ↔ 759By similarity
Disulfide bondi753 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi786 ↔ 797By similarity
Disulfide bondi791 ↔ 806By similarity
Disulfide bondi808 ↔ 817By similarity
Disulfide bondi824 ↔ 835By similarity
Disulfide bondi829 ↔ 844By similarity
Disulfide bondi846 ↔ 855By similarity
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi991N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1045N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1064N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9QXX0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QXX0

PRoteomics IDEntifications database

More...
PRIDEi
Q9QXX0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QXX0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QXX0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9QXX0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 8.75-9.75 dpc expression was detected in structures that include those destined to contribute to the cardiovascular system of the adult heart. Expression was also detected in the mesencephalon and rhombencephalon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027276 Expressed in 384 organ(s), highest expression level in pineal body

CleanEx database of gene expression profiles

More...
CleanExi
MM_JAG1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9QXX0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QXX0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NOTCH1, NOTCH2 and NOTCH3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200854, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028735

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9QXX0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QXX0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini185 – 229DSLPROSITE-ProRule annotationAdd BLAST45
Domaini230 – 263EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini264 – 294EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini296 – 334EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini336 – 372EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini374 – 410EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini412 – 448EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini450 – 485EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini487 – 523EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini525 – 561EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini586 – 627EGF-like 10PROSITE-ProRule annotationAdd BLAST42
Domaini629 – 665EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini667 – 703EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini705 – 741EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini744 – 780EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini782 – 818EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini820 – 856EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni199 – 207Important for interaction with NOTCH1By similarity9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DSL domain is indispensable and sufficient for binding to NOTCH2.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160148

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113124

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG031645

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QXX0

KEGG Orthology (KO)

More...
KOi
K06052

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRSINCK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0A88

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QXX0

TreeFam database of animal gene trees

More...
TreeFami
TF351835

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 11 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 1 hit
PF07657 MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02059 JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 16 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSPRTRGRP GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ
60 70 80 90 100
NGNCCGGVRN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP
110 120 130 140 150
VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTIQPDS
160 170 180 190 200
IIEKASHSGM INPSRQWQTL KQNTGIAHFE YQIRVTCDDH YYGFGCNKFC
210 220 230 240 250
RPRDDFFGHY ACDQNGNKTC MEGWMGPDCN KAICRQGCSP KHGSCKLPGD
260 270 280 290 300
CRCQYGWQGL YCDKCIPHPG CVHGTCNEPW QCLCETNWGG QLCDKDLNYC
310 320 330 340 350
GTHQPCLNRG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS
360 370 380 390 400
CKETSSGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC
410 420 430 440 450
PPQWTGKTCQ LDANECEAKP CVNARSCKNL IASYYCDCLP GWMGQNCDIN
460 470 480 490 500
INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG
510 520 530 540 550
HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK
560 570 580 590 600
CPEDYEGKNC SHLKDHCRTT TCEVIDSCTV AMASNDTPEG VRYISSNVCG
610 620 630 640 650
PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCKN GGTCIDGVNS
660 670 680 690 700
YKCICSDGWE GAHCENNIND CSQNPCHYGG TCRDLVNDFY CDCKNGWKGK
710 720 730 740 750
TCHSRDSQCD EATCNNGGTC YDEVDTFKCM CPGGWEGTTC NIARNSSCLP
760 770 780 790 800
NPCHNGGTCV VNGDSFTCVC KEGWEGPICT QNTNDCSPHP CYNSGTCVDG
810 820 830 840 850
DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYQCICPPGH
860 870 880 890 900
SGAKCHEVSG RSCITMGRVI LDGAKWDDDC NTCQCLNGRV ACSKVWCGPR
910 920 930 940 950
PCRLHKSHNE CPSGQSCIPV LDDQCFVRPC TGVGECRSSS LQPVKTKCTS
960 970 980 990 1000
DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI
1010 1020 1030 1040 1050
ACEPSLSANN EIHVAISAED IRDDGNPVKE ITDKIIDLVS KRDGNSSLIA
1060 1070 1080 1090 1100
AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WVCCLVTAFY WCVRKRRKPS
1110 1120 1130 1140 1150
SHTHSAPEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR
1160 1170 1180 1190 1200
THNSEVEEDD MDKHQQKVRF AKQPVYTLVD REEKAPSGTP TKHPNWTNKQ
1210
DNRDLESAQS LNRMEYIV
Length:1,218
Mass (Da):134,164
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77739F8928BB793C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF171092 mRNA Translation: AAF15505.1
BC058675 mRNA Translation: AAH58675.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16797.1

NCBI Reference Sequences

More...
RefSeqi
NP_038850.1, NM_013822.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.22398

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028735; ENSMUSP00000028735; ENSMUSG00000027276

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16449

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16449

UCSC genome browser

More...
UCSCi
uc008moz.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171092 mRNA Translation: AAF15505.1
BC058675 mRNA Translation: AAH58675.1
CCDSiCCDS16797.1
RefSeqiNP_038850.1, NM_013822.5
UniGeneiMm.22398

3D structure databases

ProteinModelPortaliQ9QXX0
SMRiQ9QXX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200854, 1 interactor
STRINGi10090.ENSMUSP00000028735

PTM databases

iPTMnetiQ9QXX0
PhosphoSitePlusiQ9QXX0
SwissPalmiQ9QXX0

Proteomic databases

MaxQBiQ9QXX0
PaxDbiQ9QXX0
PRIDEiQ9QXX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028735; ENSMUSP00000028735; ENSMUSG00000027276
GeneIDi16449
KEGGimmu:16449
UCSCiuc008moz.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
182
MGIiMGI:1095416 Jag1

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00940000160148
HOGENOMiHOG000113124
HOVERGENiHBG031645
InParanoidiQ9QXX0
KOiK06052
OMAiKRSINCK
OrthoDBiEOG091G0A88
PhylomeDBiQ9QXX0
TreeFamiTF351835

Enzyme and pathway databases

ReactomeiR-MMU-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Jag1 mouse

Protein Ontology

More...
PROi
PR:Q9QXX0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027276 Expressed in 384 organ(s), highest expression level in pineal body
CleanExiMM_JAG1
ExpressionAtlasiQ9QXX0 baseline and differential
GenevisibleiQ9QXX0 MM

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 11 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 1 hit
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 16 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJAG1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QXX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: December 5, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again